To evaluate the potential effects Ankaferd Blood Stopper (ABS) and oxytocin (OT) in an experimental model of endometriosis, 18 female Sprague Dawley rats were used in this study. The animals were randomly divided into three groups after surgical induction of endometriosis: group 1: control group (isotonic saline, 1 mL / kg / day, intramuscular, n = 6); Group 2: PL group (OT, 80 U / kg / day, intramuscular, n = 6); group 3 : a group of ABS (ABS, 1.5 mL / kg / day, intraperitoneal, n = 6). Each group was treated for four weeks (twice per week).

Endometriosis explant volume is measured in biopsy samples for histopathological analysis. Vascular endothelial growth factor (VEGF), monocytes chemotactic protein level -1 (MCP-1) and tumor necrosis factor (TNF-α) measured in plasma and peritoneal fluid. endometriosis explants volume significantly decreased after administration of OT (P <0.0001). Epithelial score was significantly decreased in both treatment groups compared with the control group (P <0.05). TUNEL immunohistochemistry showed more changes in endometriosis focus apoptosis (epithelial gland and surrounding tissue) in the PL group than the control group (P <0.05).

The level of VEGF, MCP-1 and TNF-α were significantly reduced in the OT group (P <0.05), whereas no significant change in the protein to levels found in the group of ABS-applied. Results showed that OT has a greater potential as a therapeutic agent in experimentally induced peritoneal endometriosis, in which the ABS, which is a modulator of VEGF, appear to act through different mechanisms to demonstrate palliative effect in a mouse model of peritoneal endometriosis.

The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model
The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model

Sphingosine 1-phosphate / microRNA-1249-5p / MCP-1 axis is involved in the inflammation associated macrophage fatty liver injury in mice

monocytes chemotactic protein -1 (MCP-1) is one of the most representative inflammatory cytokines, and has proven to markedly increased in liver injury and sphingosine 1-phosphate (S1P) -treated macrophages. However, microRNAs (miRNAs) are targeting MCP-1 and the role of miRNA / MCP-1 axis in S1P-mediated liver inflammation remains unknown. Here we show that the expression of MCP-1 increased in the liver and macrophages isolated rat heart MCDHF. In addition, there is a positive correlation between the degree of hepatic S1P and MCP-1.

We then predict the MCP-1 targeting miRNAs with bioinformatics analyzes and miRNA-1249-5p select (mir-1249-5p) from the intersection of database TargetScan and down-regulated miRNAs in the liver injured. S1P significantly up-regulate the expression of MCP-1 and miR-1249-5p decrease in expression in macrophages. MiR-1249-5p directly target of 3 ‘- UTR of MCP-1 and negatively regulates the expression of the S1P-treated macrophages. Mir-1249-5p agomir administration decreased liver MCP-1 levels and attenuates hepatic inflammation in mice MCDHF.

Protein – protein interaction network by displaying STRING that S1P system is closely related to MCP-1 / CCR2 axis in inflammatory tissue. In conclusion, we characterize the important role of miR-1249-5p in negatively regulates the expression of MCP-1 in vitro and in vivo, which can open up new perspectives for pharmacological treatment of heart disease. This article is protected by copyright. All rights reserved.Single nucleotide polymorphisms in miRNA binding sites (mir-SNP) that are associated with cancer risk.

(RS)-MCPG

B6265-25 25 mg
EUR 602.4

(RS)-MCPG

B6265-5 5 mg
EUR 234

(RS)-MCPG

B6265-5.1 10 mM (in 1mL DMSO)
EUR 250.8

(RS)-MCPG

B6265-50 50 mg
EUR 1015.2

(S)-MCPG

B6266-10 10 mg
EUR 211.2

(S)-MCPG

B6266-25 25 mg
EUR 420

(S)-MCPG

B6266-5 5 mg
EUR 139.2

(RS)-MCPG

HY-100371 100mg
EUR 1135.2

(S)-MCPG

HY-100406 5mg
EUR 159.6

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 362.4

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 1336.8

Nerve Terminal Staining Kit II (component A: 1x1mg AM1-43 (#70024); component B: 1x100mg SCAS (#70037))

70031-1 1SET
EUR 420
Description: Minimum order quantity: 1 unit of 1SET

SynaptoRed C1: (5x1mg)

70041 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

BD collagen i rat tail bulk 10x100mg

356236 PK10
EUR 1724.4

SynaptoRed C2 (also known as FM4-64): (5x1mg)

70027 5ST
EUR 481.2
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C1(special packaging): (5x1mg)

70043 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C5 (special packaging): (5x1mg)

70047 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreenâ„¢ C3 (special packaging): (5x1mg)

70026 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C4 (also known as FM1-43) (special packaging): (5x1mg)

70022 5ST
EUR 481.2
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C2 (also known as FM2-10)(special packaging): (5x1mg)

70045 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

SIN-1(3-morpholinosydnonimine, hydrochloride): (25x1mg)

00221-1 25ST
EUR 182.4
Description: Minimum order quantity: 1 unit of 25ST

SynaptoGreen C18 (also known as FM3-25)(special packaging) : (5x1mg)

70049 5ST
EUR 546
Description: Minimum order quantity: 1 unit of 5ST

Accuris™ Class E2, Calibration set for Analytical Balances, 6 pcs: 1x100mg, 1x10g, 2x20g, 1x50g, 1x100g

W1101-6-100 1 PC
EUR 639.7

5-(and-6)-Carboxyrhodamine 110-X, hydrochloride (5(6)-CR 110-X):5mg

90001 5MG
EUR 339.6
Description: Minimum order quantity: 1 unit of 5MG

5-(and-6)-Carboxyrhodamine 110-X, hydrochloride (5(6)-CR 110-X):5mg

90002 5MG
EUR 260.4
Description: Minimum order quantity: 1 unit of 5MG

5-(and-6)-Carboxyrhodamine 110-X, succinimidyl ester, hydrochloride (5(6)-CR 110-X, SE): (5mg)

90003 5MG
EUR 368.4
Description: Minimum order quantity: 1 unit of 5MG

hybex™ Media storage bottle, STARTER PACK (GL45) blue cap (Includes 2x100ml, 3x250ml, 3x500ml and 2x1000ml)

B3000-SP-B 1 each
EUR 146.7

Insert for 1x15ml Tube 17x100mm

CEN1022 EACH
EUR 136.8

Hettich Insert for 1x25ml Tube 17x100mm

CEN0333 EACH
EUR 136.8

MAGic Clamp™ Tube Rack, 30x15ml &20x50ml tubes (max. 4)

H1000-MR-1550 1 PC
EUR 175.8

Kinesis 5X5M X 250uM/363uM VSD TuBING

CHR1814 EACH
EUR 441.6

OPTIONAL HEAD FOR 8X15ML AND 8X12/13MM DIAMETER TUBES

480103 1/pk
EUR 75.6
Description: Lab Equipment; Shakers & Mixers

HydraGreen? Safe DNA Dye, 1ml (sufficient for 400x50ml or 200x100ml agarose gels)

ACT-IDMG04 each
EUR 247.2

Bags Ldpe 229X457Mm

6255-0918 PK50
EUR 93.6

10x10/15ml+20x5/7ml Drum

MIX1196 EACH
EUR 213.6

Basket 145x280mm

WAS3106 EACH
EUR 66

TBG-NP MET 15.0X20.0X2.5 10m

TUB6290 10MTR
EUR 102

Durx 670 Wipes 230x230mm

CLE4012 PK300
EUR 52.8

Durx 770 Wipes 230x230mm

CLE4014 PK300
EUR 140.4

Lab Jack 100x100mm Blue

JAC1000 EACH
EUR 166.8

Lab Jack 150x150mm Blue

JAC1004 EACH
EUR 220.8

Lab Jack 200x200mm Blue

JAC1008 EACH
EUR 277.2

Lab Jack 200x230mm Blue

JAC1012 EACH
EUR 337.2

Lab Jack 320x260mm Blue

JAC1013 EACH
EUR 752.4

Bench Mats 300X300mm

EDU1010 PK10
EUR 28.8

Sign 210x148mm Do Not Use Mob..

PH01051R EACH
EUR 10.44

Sign 210x148mm Do Not Use Mob..

PH01051S EACH
EUR 6.53

Sign 210x148mm No Food Or Dri..

PH03351R EACH
EUR 11.76

Sign 210x148mm No Food Or Dri..

PH03351S EACH
EUR 6.54

Test Tube 16x100mm

3840/16X100 PK100
EUR 66

Retort Rod SS 500x10mm

STA1120 EACH
EUR 30

Pipette Jar 514X165Mm

5242-0040 EACH
EUR 241.2

Bags Self Seal HD 127x203mm

HD20 PK1000
EUR 104.45

Sign 210x148mm Do Not Drink R..

PH00251R EACH
EUR 10.44

Pipette Jar 162x650mm

WAS3104 EACH
EUR 145.2

Foam bung 38x50mm hd

FOB010 PK100
EUR 44.13

Egg Shape, 30X10mm

ST016 1 UNIT
EUR 69.4

Egg Shape, 40X15mm

ST017 1 UNIT
EUR 72.53

Egg Shape, 50X20mm

ST018 1 UNIT
EUR 74.62

Egg Shape, 70X25mm

ST019 1 UNIT
EUR 85.06

150x50mm Pull - Rigid

FX05312R EACH
EUR 7.84

150x50mm Push - Rigid

FX05512R EACH
EUR 7.84

Adapter for 11x75-100mm

E5910704003 PK2
EUR 248.4

Hybond LFP 0.2 PVDF 200x200mm

10600060 PK10
EUR 346.8

PP Labels J2000 105x155mm

LAB0150 PK1250
EUR 128.4

Sign 300x500mm No Smoking/No ..

MS05529R EACH
EUR 32.64

Beta Base Plate 450x406mm

SAF6588 EACH
EUR 211.51

DISH,60X15MM,GRID,TCT,PS,S,BK,20/500

430196 20/pk
EUR 288
Description: Lab Cell Culture; Corning TC Dishes

Lab Jack 50x40mm Blue

JAC0998 EACH
EUR 176.4

Glass Cell 10x10mm UV

FLU1102 EACH
EUR 374.4

Glass Cell 10X10Mm

SPE1226 EACH
EUR 106.8

TBG-NP-MET 6.0X10.0X2.0 25m

TUB6276 25MTR
EUR 147.6

TBG-NP-MET 7.0X10.0X1.5 25m

TUB6278 25MTR
EUR 153.6

TBG-NP-MET 8.0X11.0X1.5 25m

TUB6280 25MTR
EUR 159.6

TBG-NP-MET 8.0X12.0X2.0 25m

TUB6282 25MTR
EUR 169.2

TBG-NP-MET 9.0X13.0X2.0 25m

TUB6284 25MTR
EUR 177.6

TBG-NP-MET 10.0X14.0X2.0 25m

TUB6286 25MTR
EUR 205.2

TBG-NP-MET 12.0X16.0X2.0 25m

TUB6288 25MTR
EUR 226.8

Foam Plugs 50x38mm

STO6400 PK100
EUR 79.64

Foam Plugs 50x50mm

STO6402 PK100
EUR 83.56

Foam Plugs 50x25mm

STO6404 PK100
EUR 42.82

Foam Plugs 75x75mm

STO6406 PK100
EUR 120.12

Sign 75x600mm Push Bar To Ope..

FX05645R EACH
EUR 15.67

Egg Shape, 15X7mm

ST012 1 UNIT
EUR 64.7

Egg Shape, 20X8mm

ST013 1 UNIT
EUR 65.22

Egg Shape, 25X9mm

ST014 1 UNIT
EUR 65.75

Hi-Low Labels 33x13mm 22x90

LAB2240 EACH
EUR 51.18

Human MCP-1 ELISA kit (4X96T)

LF-EK50226 4×96T
EUR 2641.2

Mouse MCP-1 ELISA kit (4X96T)

LF-EK50672 4×96T
EUR 2641.2

Hi-Low Labels 25x13mm 16x126

LAB2242 EACH
EUR 48.18

Rack Nalge White 109X109Mm

5972-0030 EACH
EUR 25.2

Autoclave Bag PP 634x413mm

AUT1410 PK500
EUR 215.42

600x420mm COSHH Poster

CAS0010 EACH
EUR 39.24

Bag Specimen+Doc PE 125x140mm

BAG1200 PK100
EUR 25

Bag Specimen+Doc PE 150x240mm

BAG1208 PK100
EUR 40.21

Bags Red Heavy Duty 725x975mm

BAG2204 PK200
EUR 49.22

Sign 300x300mm No Smoking/Dri..

MS05428R EACH
EUR 26.16

Sign 300x300mm No Smoking/Dri..

MS05428S EACH
EUR 14.36

Sign 210x148mm No Entry Rigid

ML01751R EACH
EUR 10.44

Sign 210x148mm No Smoking Rig..

ML02051R EACH
EUR 10.44

Sign 297x210mm Fire Action No..

FR03550R EACH
EUR 18.28

Sign 210x148mm Fire Action No..

FR03551R EACH
EUR 10.44

Sign 210x148mm Fire Alarm Rig..

FR03751R EACH
EUR 14.36

Sign 100x100mm Fire Door Keep..

FR06802R EACH
EUR 5.22

Sign 250x300mm Know Your Fire..

FR08721R EACH
EUR 22.2

100x100mm Toxic GHS sheet

GHSC100TO EACH
EUR 20.9

Sign 150x125mm Danger Acid Se..

HA08507S EACH
EUR 9.84

Sign 210x148mm Danger Trip Ha..

HA17151R EACH
EUR 14.36

Sign 210x148mm Wear Mask Rigi..

HA27651R EACH
EUR 11.75

Sign 150x450mm Fire Exit Symb..

FX04011R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..

FX04111R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..

FX04211R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..

FX04311R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..

FX04411R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..

FX04511R EACH
EUR 19.58

Sign 150x450mm Fire Exit/Keep..

FX05111R EACH
EUR 19.58

Sign 210x148mm No Naked Light..

PH04051R EACH
EUR 10.44

Sign 210x148mm No Smoking Leg..

PH05051R EACH
EUR 10.44

H-Flex 1 33x10/12mL Adpt set/2

75003305 PK2
EUR 1086

Rotor Angle 12x15ml RB/FA

CEN2630 EACH
EUR 408

Rotor Angle 6x250ml FB ID

CEN2658 EACH
EUR 3140.4

Rotor Angle 10x50ml FA ID

CEN2668 EACH
EUR 2260.8

Rotor Angle 30x15ml RB/FA ID

CEN2672 EACH
EUR 1272

Rack 14x15mL D17mm FA 2PK

CEN2732 PK2
EUR 286.8

Rack 17x15mL D17mm FA 2PK

CEN2734 PK2
EUR 286.8

Rack 18x15mL D17mm RB 2PK

CEN2736 PK2
EUR 337.2

Rack 21x10mL D16mm RB 2PK

CEN2738 PK2
EUR 337.2

Adapter for 17.5x100mm

E5910709005 PK2
EUR 267.6

Cuvettes PS 10x10mm

FLU1100 PK100
EUR 155.37

Test Tubes 75X13Mm 5Ml Rb

RB31 PK2000
EUR 90

Sieve SS 200x0.25mm UKAS Cert.

SIE1048UKAS EACH
EUR 197.15

Rack PP Red 84x13mm Tubes

STA3220 EACH
EUR 22.8

Rack PP Red 55x16mm Tubes

STA3222 EACH
EUR 22.8

Rack PP Red 40x21mm Tubes

STA3224 EACH
EUR 16.8

Rack PP Red 32x26mm Tubes

STA3226 EACH
EUR 24

Rack PP Red 21x31mm Tubes

STA3228 EACH
EUR 24

BD Dish collagen i 100x20mm bp rt

356450 PK40
EUR 370.8

142x17mm Rotator Drum

MIX1276 EACH
EUR 416.4

Tube Holder 20x9-20mm SB3/2

MIX1964 EACH
EUR 218.4

Stuart Bottle 260x35mm

OVE3356 EACH
EUR 160.8

Stuart Bottle 230x70mm

OVE3358 EACH
EUR 244.8

Stuart Bottle 150x35mm

OVE3360 EACH
EUR 142.8

TPP Culture dish 146x21mm

TIS7106 PK100
EUR 319.2

El Paper Novablot 200x250Mm P 500

80110619 EACH
EUR 488.4

Biohazard bag Red 203x305mm

BAG1120 PK500
EUR 159.6

Biohazard bag Red 356x483mm

BAG1122 PK200
EUR 175.2

Biohazard bag Red 483x584mm

BAG1124 PK200
EUR 274.8

Biohazard bag Red 635x838mm

BAG1126 PK200
EUR 639.6

Bags Blue Heavy Duty 725x975mm

BAG2206 PK200
EUR 50.4

210x148mm Lab Coats Must be worn

MA03151R EACH
EUR 10.44

210x148mm Wear Face Shield

MA06451R EACH
EUR 10.44

Adhering Mat Blue 300x300mm

MIX5058 EACH
EUR 138

Sign 150x450mm Nite-Glo Fire ..

FX04211L EACH
EUR 24.84

Sign 150x450mm Nite-Glo Fire ..

FX04311L EACH
EUR 24.84

Sign 150x450mm Nite-Glo Fire ..

FX04411L EACH
EUR 24.84

TBG-NP-MET 4.0X6.0X1.0 25m

TUB6268 25MTR
EUR 56.4

TBG-NP-MET 4.0X7.0X1.5 25m

TUB6270 25MTR
EUR 72

TBG-NP-MET 5.0X8.0X1.5 25m

TUB6272 25MTR
EUR 97.2

TBG-NP-MET 6.0X9.0X1.5 25m

TUB6274 25MTR
EUR 129.6

RotoBot Programmable Rotator, includes tube holders for 30x1.5ml, 8x15ml and 2x50ml

R4045 1 each
EUR 1056.2

RotoBot Programmable Rotator, includes tube holders for 30x1.5ml, 8x15ml and 2x50ml, 240V

R4045-E 1 PC
EUR 1056.2

H-Flex 1 18x15mL Adptr set/2

75003304 PK2
EUR 1086

Coverslip no.1 24x60mm

BB024060A1 PK1000
EUR 122.73

PP Labels J2000 33.02x15.24mm

LAB0156 PK1500
EUR 188.4

Labels On Roll, Red, 30X15mm

LB002R 1ROLLS, 1 UNIT
EUR 65.22

Labels On Roll, Red, 40X20mm

LB102R 1ROLLS, 1 UNIT
EUR 65.3

30x15ml Rotator Drum

MIX1148 EACH
EUR 213.6

15x50ml Rotator Drum

MIX1158 EACH
EUR 213.6

64x14mm Rotator Drum

MIX1198 EACH
EUR 213.6

76x26mm Rotator Drum

MIX1278 EACH
EUR 362.4

60x30mm Rotator Drum

MIX1280 EACH
EUR 362.4

Tube holder 12x50ml SB3/3

MIX1966 EACH
EUR 264

Tube Holder 63x12mm SB3/4

MIX1968 EACH
EUR 288

Riffle Box StSt 12x13mm

SIE1332 EACH
EUR 1152.84

Rack PP Blue 60x16mm Tubes

STA3212 EACH
EUR 36.6

Rack PP Blue 40x21mm Tubes

STA3214 EACH
EUR 21.6

Rack PP Blue 32x26mm Tubes

STA3216 EACH
EUR 30

Rack PP Blue 21x31mm Tubes

STA3218 EACH
EUR 22.8

Select Tube 3ml 55x11mm PP

TUB0098 PK4000
EUR 205.2

Select Tube 3.5ML 75x12mm Ps

TUB0105 PK3000
EUR 136.8

Select Tube 3.5ml 75x12mm PP

TUB0106 PK2500
EUR 121.2

Injector Jet 4x160mm

WAS6138 EACH
EUR 30.03

Injector Jet 6x200mm

WAS6156 EACH
EUR 47

Injector Jet 6x220mm

WAS6158 EACH
EUR 47

Injector Jet 6x240mm

WAS6160 EACH
EUR 47

Nunc 12ml Tube 100x15mm with Cap

343141 PK500
EUR 219.6

Filter Paper No1 75X100mm

FIL2042 PK500
EUR 79.2

Tile Spotting PPR 117X95mm

TIL1010 PK10
EUR 50.4

We assessed the association between five miR-SNP in the 3 ‘translated regions ( 3 ‘ – UTR) of RYR 3 (rs1044129), KIAA042 3 (rs105 3 667), C14orf101 (rs4901706), GOLGA7 < / i> (rs11 3 3 7), and KRT81 (rs 3 660) and breast cancer risk ( BC).