To evaluate the potential effects Ankaferd Blood Stopper (ABS) and oxytocin (OT) in an experimental model of endometriosis, 18 female Sprague Dawley rats were used in this study. The animals were randomly divided into three groups after surgical induction of endometriosis: group 1: control group (isotonic saline, 1 mL / kg / day, intramuscular, n = 6); Group 2: PL group (OT, 80 U / kg / day, intramuscular, n = 6); group 3 : a group of ABS (ABS, 1.5 mL / kg / day, intraperitoneal, n = 6). Each group was treated for four weeks (twice per week).

Endometriosis explant volume is measured in biopsy samples for histopathological analysis. Vascular endothelial growth factor (VEGF), monocytes chemotactic protein level -1 (MCP-1) and tumor necrosis factor (TNF-α) measured in plasma and peritoneal fluid. endometriosis explants volume significantly decreased after administration of OT (P <0.0001). Epithelial score was significantly decreased in both treatment groups compared with the control group (P <0.05). TUNEL immunohistochemistry showed more changes in endometriosis focus apoptosis (epithelial gland and surrounding tissue) in the PL group than the control group (P <0.05).

The level of VEGF, MCP-1 and TNF-α were significantly reduced in the OT group (P <0.05), whereas no significant change in the protein to levels found in the group of ABS-applied. Results showed that OT has a greater potential as a therapeutic agent in experimentally induced peritoneal endometriosis, in which the ABS, which is a modulator of VEGF, appear to act through different mechanisms to demonstrate palliative effect in a mouse model of peritoneal endometriosis.

The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model
The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model

Sphingosine 1-phosphate / microRNA-1249-5p / MCP-1 axis is involved in the inflammation associated macrophage fatty liver injury in mice

monocytes chemotactic protein -1 (MCP-1) is one of the most representative inflammatory cytokines, and has proven to markedly increased in liver injury and sphingosine 1-phosphate (S1P) -treated macrophages. However, microRNAs (miRNAs) are targeting MCP-1 and the role of miRNA / MCP-1 axis in S1P-mediated liver inflammation remains unknown. Here we show that the expression of MCP-1 increased in the liver and macrophages isolated rat heart MCDHF. In addition, there is a positive correlation between the degree of hepatic S1P and MCP-1.

We then predict the MCP-1 targeting miRNAs with bioinformatics analyzes and miRNA-1249-5p select (mir-1249-5p) from the intersection of database TargetScan and down-regulated miRNAs in the liver injured. S1P significantly up-regulate the expression of MCP-1 and miR-1249-5p decrease in expression in macrophages. MiR-1249-5p directly target of 3 ‘- UTR of MCP-1 and negatively regulates the expression of the S1P-treated macrophages. Mir-1249-5p agomir administration decreased liver MCP-1 levels and attenuates hepatic inflammation in mice MCDHF.

Protein – protein interaction network by displaying STRING that S1P system is closely related to MCP-1 / CCR2 axis in inflammatory tissue. In conclusion, we characterize the important role of miR-1249-5p in negatively regulates the expression of MCP-1 in vitro and in vivo, which can open up new perspectives for pharmacological treatment of heart disease. This article is protected by copyright. All rights reserved.Single nucleotide polymorphisms in miRNA binding sites (mir-SNP) that are associated with cancer risk.

(RS)-MCPG
B6265-25 25 mg
EUR 602.4

(RS)-MCPG
B6265-5 5 mg
EUR 234

(RS)-MCPG
B6265-5.1 10 mM (in 1mL DMSO)
EUR 250.8

(RS)-MCPG
B6265-50 50 mg
EUR 1015.2

(S)-MCPG
B6266-10 10 mg
EUR 211.2

(S)-MCPG
B6266-25 25 mg
EUR 420

(S)-MCPG
B6266-5 5 mg
EUR 139.2

(RS)-MCPG
HY-100371 100mg
EUR 1135.2

(S)-MCPG
HY-100406 5mg
EUR 159.6

(S)-MCPG
B6266-50 50mg
EUR 654
Description: mGluR antagonist

(RS)-MCPG disodium salt
B7476-10 10 mg
EUR 362.4

(RS)-MCPG disodium salt
B7476-50 50 mg
EUR 1336.8

(RS)-MCPG disodium salt
B7476-100 100mg
EUR 1125
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt
B7476-25 25mg
EUR 348
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt
B7476-5 5mg
EUR 114
Description: group I/group II metabotropic glutamate receptor antagonist

DID (DIIC18(5)), 5x1mg
60014-5mg 5MG
EUR 130
Description: N/A

DIR (DIIC18(7)), 5x1mg
60017-5mg 5MG
EUR 172
Description: N/A

Nerve Terminal Staining Kit II (component A: 1x1mg AM1-43 (#70024); component B: 1x100mg SCAS (#70037))
70031-1 1SET
EUR 420
Description: Minimum order quantity: 1 unit of 1SET

SynaptoRed C1: (5x1mg)
70041 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

BD collagen i rat tail bulk 10x100mg
356236 PK10
EUR 1724.4

SynaptoRed C2 (also known as FM4-64): (5x1mg)
70027 5ST
EUR 481.2
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C1(special packaging): (5x1mg)
70043 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C5 (special packaging): (5x1mg)
70047 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreenâ„¢ C3 (special packaging): (5x1mg)
70026 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

Mix-n-Stain™ Maxi CF®555 Antibody Labeling Kit, 1x1mg labeling
92406 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®568 Antibody Labeling Kit, 1x1mg labeling
92407 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®594 Antibody Labeling Kit, 1x1mg labeling
92408 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®633 Antibody Labeling Kit, 1x1mg labeling
92409 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®647 Antibody Labeling Kit, 1x1mg labeling
92410 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®350 Antibody Labeling Kit, 1x1mg labeling
92420 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®680 Antibody Labeling Kit, 1x1mg labeling
92422 -
EUR 602
Description: N/A

Mix-n-Stain™ Maxi CF®750 Antibody Labeling Kit, 1x1mg labeling
92423 -
EUR 602
Description: N/A

Mix-n-Stain™ Maxi CF®770 Antibody Labeling Kit, 1x1mg labeling
92424 -
EUR 602
Description: N/A

Mix-n-Stain™ Maxi CF®405M Antibody Labeling Kit, 1x1mg labeling
92404 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®488A Antibody Labeling Kit, 1x1mg labeling
92405 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®405S Antibody Labeling Kit, 1x1mg labeling
92421 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®405L Antibody Labeling Kit, 1x1mg labeling
92454 -
EUR 577
Description: N/A

SynaptoGreen C4 (also known as FM1-43) (special packaging): (5x1mg)
70022 5ST
EUR 481.2
Description: Minimum order quantity: 1 unit of 5ST

SynaptoGreen C2 (also known as FM2-10)(special packaging): (5x1mg)
70045 5ST
EUR 384
Description: Minimum order quantity: 1 unit of 5ST

Mix-n-Stain™ Maxi FITC Antibody Labeling Kit, 1x1mg labeling
92411 -
EUR 577
Description: N/A

SIN-1(3-morpholinosydnonimine, hydrochloride): (25x1mg)
00221-1 25ST
EUR 182.4
Description: Minimum order quantity: 1 unit of 25ST

SynaptoGreen C18 (also known as FM3-25)(special packaging) : (5x1mg)
70049 5ST
EUR 546
Description: Minimum order quantity: 1 unit of 5ST

Mix-n-Stain™ Maxi Cyanine 555 Antibody Labeling Kit, 1x1mg labeling
92415 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi Cyanine 647 Antibody Labeling Kit, 1x1mg labeling
92419 -
EUR 577
Description: N/A

Accuris™ Class E2, Calibration set for Analytical Balances, 6 pcs: 1x100mg, 1x10g, 2x20g, 1x50g, 1x100g
W1101-6-100 1 PC
EUR 639.7

5-(and-6)-Carboxyrhodamine 110-X, hydrochloride (5(6)-CR 110-X):5mg
90001 5MG
EUR 339.6
Description: Minimum order quantity: 1 unit of 5MG

5-(and-6)-Carboxyrhodamine 110-X, hydrochloride (5(6)-CR 110-X):5mg
90002 5MG
EUR 260.4
Description: Minimum order quantity: 1 unit of 5MG

5-(and-6)-Carboxyrhodamine 110-X, succinimidyl ester, hydrochloride (5(6)-CR 110-X, SE): (5mg)
90003 5MG
EUR 368.4
Description: Minimum order quantity: 1 unit of 5MG

Cyclin B2(X29.2), 0.2mg/mL
BNUB3059-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Cyclin B2(X29.2), 0.2mg/mL
BNUB3059-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Cyclin B2(X29.2), 1mg/mL
BNUM3059-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

hybex™ Media storage bottle, STARTER PACK (GL45) blue cap (Includes 2x100ml, 3x250ml, 3x500ml and 2x1000ml)
B3000-SP-B 1 each
EUR 146.7

Insert for 1x15ml Tube 17x100mm
CEN1022 EACH
EUR 136.8

Hettich Insert for 1x25ml Tube 17x100mm
CEN0333 EACH
EUR 136.8

MAGic Clamp™ Tube Rack, 30x15ml &20x50ml tubes (max. 4)
H1000-MR-1550 1 PC
EUR 175.8

Kinesis 5X5M X 250uM/363uM VSD TuBING
CHR1814 EACH
EUR 441.6

OPTIONAL HEAD FOR 8X15ML AND 8X12/13MM DIAMETER TUBES
480103 1/pk
EUR 75.6
Description: Lab Equipment; Shakers & Mixers

HydraGreen? Safe DNA Dye, 1ml (sufficient for 400x50ml or 200x100ml agarose gels)
ACT-IDMG04 each
EUR 247.2

HydraGreen™ Safe DNA Dye, 1ml (sufficient for 400x50ml or 200x100ml agarose gels)
ACT IDMG04
EUR 135.53

Bags Ldpe 229X457Mm
6255-0918 PK50
EUR 93.6

10x10/15ml+20x5/7ml Drum
MIX1196 EACH
EUR 213.6

Basket 145x280mm
WAS3106 EACH
EUR 66

TBG-NP MET 15.0X20.0X2.5 10m
TUB6290 10MTR
EUR 102

Durx 670 Wipes 230x230mm
CLE4012 PK300
EUR 52.8

Durx 770 Wipes 230x230mm
CLE4014 PK300
EUR 140.4

Sign 210x148mm Do Not Use Mob..
PH01051R EACH
EUR 10.44

Sign 210x148mm Do Not Use Mob..
PH01051S EACH
EUR 6.53

Sign 210x148mm No Food Or Dri..
PH03351R EACH
EUR 11.76

Sign 210x148mm No Food Or Dri..
PH03351S EACH
EUR 6.54

Bench Mats 300X300mm
EDU1010 PK10
EUR 28.8

Lab Jack 100x100mm Blue
JAC1000 EACH
EUR 166.8

Lab Jack 150x150mm Blue
JAC1004 EACH
EUR 220.8

Lab Jack 200x200mm Blue
JAC1008 EACH
EUR 277.2

Lab Jack 200x230mm Blue
JAC1012 EACH
EUR 337.2

Lab Jack 320x260mm Blue
JAC1013 EACH
EUR 752.4

Test Tube 16x100mm
3840/16X100 PK100
EUR 66

Retort Rod SS 500x10mm
STA1120 EACH
EUR 30

Foam bung 38x50mm hd
FOB010 PK100
EUR 44.13

SCF525 (50x50mm)
2008061 each
EUR 52800

EDTA SOL. (0.5M) pH8.0 4x100ML
IB70185 -
EUR 88.53
Description: (MADE FROM (4) IB70184)

Egg Shape, 30X10mm
ST016 1 UNIT
EUR 69.4

Egg Shape, 40X15mm
ST017 1 UNIT
EUR 72.53

Egg Shape, 50X20mm
ST018 1 UNIT
EUR 74.62

Egg Shape, 70X25mm
ST019 1 UNIT
EUR 85.06

Pipette Jar 514X165Mm
5242-0040 EACH
EUR 241.2

Sign 210x148mm Do Not Drink R..
PH00251R EACH
EUR 10.44

Bags Self Seal HD 127x203mm
HD20 PK1000
EUR 104.45

Pipette Jar 162x650mm
WAS3104 EACH
EUR 145.2

150x50mm Pull - Rigid
FX05312R EACH
EUR 7.84

150x50mm Push - Rigid
FX05512R EACH
EUR 7.84

Adapter for 11x75-100mm
E5910704003 PK2
EUR 248.4

Hybond LFP 0.2 PVDF 200x200mm
10600060 PK10
EUR 346.8

Sign 300x500mm No Smoking/No ..
MS05529R EACH
EUR 32.64

PP Labels J2000 105x155mm
LAB0150 PK1250
EUR 128.4

Beta Base Plate 450x406mm
SAF6588 EACH
EUR 211.51

DISH,60X15MM,GRID,TCT,PS,S,BK,20/500
430196 20/pk
EUR 288
Description: Lab Cell Culture; Corning TC Dishes

Glass Cell 10x10mm UV
FLU1102 EACH
EUR 374.4

Lab Jack 50x40mm Blue
JAC0998 EACH
EUR 176.4

TBG-NP-MET 6.0X10.0X2.0 25m
TUB6276 25MTR
EUR 147.6

TBG-NP-MET 7.0X10.0X1.5 25m
TUB6278 25MTR
EUR 153.6

TBG-NP-MET 8.0X11.0X1.5 25m
TUB6280 25MTR
EUR 159.6

TBG-NP-MET 8.0X12.0X2.0 25m
TUB6282 25MTR
EUR 169.2

TBG-NP-MET 9.0X13.0X2.0 25m
TUB6284 25MTR
EUR 177.6

TBG-NP-MET 10.0X14.0X2.0 25m
TUB6286 25MTR
EUR 205.2

TBG-NP-MET 12.0X16.0X2.0 25m
TUB6288 25MTR
EUR 226.8

Glass Cell 10X10Mm
SPE1226 EACH
EUR 106.8

Foam Plugs 50x38mm
STO6400 PK100
EUR 79.64

Foam Plugs 50x50mm
STO6402 PK100
EUR 83.56

Foam Plugs 50x25mm
STO6404 PK100
EUR 42.82

Foam Plugs 75x75mm
STO6406 PK100
EUR 120.12

Sign 75x600mm Push Bar To Ope..
FX05645R EACH
EUR 15.67

Egg Shape, 15X7mm
ST012 1 UNIT
EUR 64.7

Egg Shape, 20X8mm
ST013 1 UNIT
EUR 65.22

Egg Shape, 25X9mm
ST014 1 UNIT
EUR 65.75

Hi-Low Labels 33x13mm 22x90
LAB2240 EACH
EUR 51.18

Bag Specimen+Doc PE 125x140mm
BAG1200 PK100
EUR 25

Bag Specimen+Doc PE 150x240mm
BAG1208 PK100
EUR 40.21

Bags Red Heavy Duty 725x975mm
BAG2204 PK200
EUR 49.22

Autoclave Bag PP 634x413mm
AUT1410 PK500
EUR 215.42

Rack Nalge White 109X109Mm
5972-0030 EACH
EUR 25.2

600x420mm COSHH Poster
CAS0010 EACH
EUR 39.24

Sign 300x300mm No Smoking/Dri..
MS05428R EACH
EUR 26.16

Sign 300x300mm No Smoking/Dri..
MS05428S EACH
EUR 14.36

Sign 210x148mm No Naked Light..
PH04051R EACH
EUR 10.44

Sign 210x148mm No Smoking Leg..
PH05051R EACH
EUR 10.44

Sign 210x148mm No Entry Rigid
ML01751R EACH
EUR 10.44

Sign 210x148mm No Smoking Rig..
ML02051R EACH
EUR 10.44

100x100mm Toxic GHS sheet
GHSC100TO EACH
EUR 20.9

Sign 297x210mm Fire Action No..
FR03550R EACH
EUR 18.28

Sign 210x148mm Fire Action No..
FR03551R EACH
EUR 10.44

Sign 210x148mm Fire Alarm Rig..
FR03751R EACH
EUR 14.36

Sign 100x100mm Fire Door Keep..
FR06802R EACH
EUR 5.22

Sign 250x300mm Know Your Fire..
FR08721R EACH
EUR 22.2

Sign 150x450mm Fire Exit Symb..
FX04011R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04111R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04211R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04311R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04411R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04511R EACH
EUR 19.58

Sign 150x450mm Fire Exit/Keep..
FX05111R EACH
EUR 19.58

Sign 150x125mm Danger Acid Se..
HA08507S EACH
EUR 9.84

Sign 210x148mm Danger Trip Ha..
HA17151R EACH
EUR 14.36

Sign 210x148mm Wear Mask Rigi..
HA27651R EACH
EUR 11.75

Hi-Low Labels 25x13mm 16x126
LAB2242 EACH
EUR 48.18

Rotor Angle 12x15ml RB/FA
CEN2630 EACH
EUR 408

Rotor Angle 6x250ml FB ID
CEN2658 EACH
EUR 3140.4

Rotor Angle 10x50ml FA ID
CEN2668 EACH
EUR 2260.8

Rotor Angle 30x15ml RB/FA ID
CEN2672 EACH
EUR 1272

Rack 14x15mL D17mm FA 2PK
CEN2732 PK2
EUR 286.8

Rack 17x15mL D17mm FA 2PK
CEN2734 PK2
EUR 286.8

Rack 18x15mL D17mm RB 2PK
CEN2736 PK2
EUR 337.2

Rack 21x10mL D16mm RB 2PK
CEN2738 PK2
EUR 337.2

H-Flex 1 33x10/12mL Adpt set/2
75003305 PK2
EUR 1086

Cuvettes PS 10x10mm
FLU1100 PK100
EUR 155.37

Adapter for 17.5x100mm
E5910709005 PK2
EUR 267.6

Sieve SS 200x0.25mm UKAS Cert.
SIE1048UKAS EACH
EUR 197.15

Test Tubes 75X13Mm 5Ml Rb
RB31 PK2000
EUR 90

Rack PP Red 84x13mm Tubes
STA3220 EACH
EUR 22.8

Rack PP Red 55x16mm Tubes
STA3222 EACH
EUR 22.8

Rack PP Red 40x21mm Tubes
STA3224 EACH
EUR 16.8

Rack PP Red 32x26mm Tubes
STA3226 EACH
EUR 24

Rack PP Red 21x31mm Tubes
STA3228 EACH
EUR 24

50x30mm Well Bar Set, per set
IW-P115 -
EUR 575

BD Dish collagen i 100x20mm bp rt
356450 PK40
EUR 370.8

Stuart Bottle 260x35mm
OVE3356 EACH
EUR 160.8

Stuart Bottle 230x70mm
OVE3358 EACH
EUR 244.8

Stuart Bottle 150x35mm
OVE3360 EACH
EUR 142.8

142x17mm Rotator Drum
MIX1276 EACH
EUR 416.4

Tube Holder 20x9-20mm SB3/2
MIX1964 EACH
EUR 218.4

TPP Culture dish 146x21mm
TIS7106 PK100
EUR 319.2

TBG-NP-MET 4.0X6.0X1.0 25m
TUB6268 25MTR
EUR 56.4

TBG-NP-MET 4.0X7.0X1.5 25m
TUB6270 25MTR
EUR 72

TBG-NP-MET 5.0X8.0X1.5 25m
TUB6272 25MTR
EUR 97.2

TBG-NP-MET 6.0X9.0X1.5 25m
TUB6274 25MTR
EUR 129.6

Biohazard bag Red 203x305mm
BAG1120 PK500
EUR 159.6

Biohazard bag Red 356x483mm
BAG1122 PK200
EUR 175.2

Biohazard bag Red 483x584mm
BAG1124 PK200
EUR 274.8

Biohazard bag Red 635x838mm
BAG1126 PK200
EUR 639.6

Bags Blue Heavy Duty 725x975mm
BAG2206 PK200
EUR 50.4

El Paper Novablot 200x250Mm P 500
80110619 EACH
EUR 488.4

210x148mm Lab Coats Must be worn
MA03151R EACH
EUR 10.44

210x148mm Wear Face Shield
MA06451R EACH
EUR 10.44

Adhering Mat Blue 300x300mm
MIX5058 EACH
EUR 138

Sign 150x450mm Nite-Glo Fire ..
FX04211L EACH
EUR 24.84

Sign 150x450mm Nite-Glo Fire ..
FX04311L EACH
EUR 24.84

Sign 150x450mm Nite-Glo Fire ..
FX04411L EACH
EUR 24.84

Accuris Probe One-Step RT-qPCR Kit, No ROX, 2500 reactions (1x25ml, 2x1.25ml)
PR2121-N-25BLK 1 each
EUR 2695

Accuris Probe One-Step RT-qPCR Kit, No ROX, 5000 reactions (1x50ml, 4x1.25ml)
PR2121-N-50BLK 1 each
EUR 4785

We assessed the association between five miR-SNP in the 3 ‘translated regions ( 3 ‘ – UTR) of RYR 3 (rs1044129), KIAA042 3 (rs105 3 667), C14orf101 (rs4901706), GOLGA7 < / i> (rs11 3 3 7), and KRT81 (rs 3 660) and breast cancer risk ( BC).