To evaluate the potential effects Ankaferd Blood Stopper (ABS) and oxytocin (OT) in an experimental model of endometriosis, 18 female Sprague Dawley rats were used in this study. The animals were randomly divided into three groups after surgical induction of endometriosis: group 1: control group (isotonic saline, 1 mL / kg / day, intramuscular, n = 6); Group 2: PL group (OT, 80 U / kg / day, intramuscular, n = 6); group 3 : a group of ABS (ABS, 1.5 mL / kg / day, intraperitoneal, n = 6). Each group was treated for four weeks (twice per week).

Endometriosis explant volume is measured in biopsy samples for histopathological analysis. Vascular endothelial growth factor (VEGF), monocytes chemotactic protein level -1 (MCP-1) and tumor necrosis factor (TNF-α) measured in plasma and peritoneal fluid. endometriosis explants volume significantly decreased after administration of OT (P <0.0001). Epithelial score was significantly decreased in both treatment groups compared with the control group (P <0.05). TUNEL immunohistochemistry showed more changes in endometriosis focus apoptosis (epithelial gland and surrounding tissue) in the PL group than the control group (P <0.05).

The level of VEGF, MCP-1 and TNF-α were significantly reduced in the OT group (P <0.05), whereas no significant change in the protein to levels found in the group of ABS-applied. Results showed that OT has a greater potential as a therapeutic agent in experimentally induced peritoneal endometriosis, in which the ABS, which is a modulator of VEGF, appear to act through different mechanisms to demonstrate palliative effect in a mouse model of peritoneal endometriosis.

The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model
The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model

Sphingosine 1-phosphate / microRNA-1249-5p / MCP-1 axis is involved in the inflammation associated macrophage fatty liver injury in mice

monocytes chemotactic protein -1 (MCP-1) is one of the most representative inflammatory cytokines, and has proven to markedly increased in liver injury and sphingosine 1-phosphate (S1P) -treated macrophages. However, microRNAs (miRNAs) are targeting MCP-1 and the role of miRNA / MCP-1 axis in S1P-mediated liver inflammation remains unknown. Here we show that the expression of MCP-1 increased in the liver and macrophages isolated rat heart MCDHF. In addition, there is a positive correlation between the degree of hepatic S1P and MCP-1.

We then predict the MCP-1 targeting miRNAs with bioinformatics analyzes and miRNA-1249-5p select (mir-1249-5p) from the intersection of database TargetScan and down-regulated miRNAs in the liver injured. S1P significantly up-regulate the expression of MCP-1 and miR-1249-5p decrease in expression in macrophages. MiR-1249-5p directly target of 3 ‘- UTR of MCP-1 and negatively regulates the expression of the S1P-treated macrophages. Mir-1249-5p agomir administration decreased liver MCP-1 levels and attenuates hepatic inflammation in mice MCDHF.

Protein – protein interaction network by displaying STRING that S1P system is closely related to MCP-1 / CCR2 axis in inflammatory tissue. In conclusion, we characterize the important role of miR-1249-5p in negatively regulates the expression of MCP-1 in vitro and in vivo, which can open up new perspectives for pharmacological treatment of heart disease. This article is protected by copyright. All rights reserved.Single nucleotide polymorphisms in miRNA binding sites (mir-SNP) that are associated with cancer risk.

(RS)-MCPG
B6265-25 25 mg
EUR 602.4

(RS)-MCPG
B6265-5 5 mg
EUR 234

(RS)-MCPG
B6265-5.1 10 mM (in 1mL DMSO)
EUR 250.8

(RS)-MCPG
B6265-50 50 mg
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(S)-MCPG
B6266-10 10 mg
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(S)-MCPG
B6266-25 25 mg
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(S)-MCPG
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(RS)-MCPG
HY-100371 100mg
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(S)-MCPG
HY-100406 5mg
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(RS)-MCPG disodium salt
B7476-10 10 mg
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(RS)-MCPG disodium salt
B7476-50 50 mg
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Nerve Terminal Staining Kit II (component A: 1x1mg AM1-43 (#70024); component B: 1x100mg SCAS (#70037))
70031-1 1SET
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Description: Minimum order quantity: 1 unit of 1SET

SynaptoRed C1: (5x1mg)
70041 5ST
EUR 384
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BD collagen i rat tail bulk 10x100mg
356236 PK10
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SynaptoRed C2 (also known as FM4-64): (5x1mg)
70027 5ST
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70043 5ST
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70047 5ST
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70026 5ST
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70022 5ST
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70045 5ST
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00221-1 25ST
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SynaptoGreen C18 (also known as FM3-25)(special packaging) : (5x1mg)
70049 5ST
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Accuris™ Class E2, Calibration set for Analytical Balances, 6 pcs: 1x100mg, 1x10g, 2x20g, 1x50g, 1x100g
W1101-6-100 1 PC
EUR 639.7

5-(and-6)-Carboxyrhodamine 110-X, hydrochloride (5(6)-CR 110-X):5mg
90001 5MG
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90002 5MG
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90003 5MG
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Description: Minimum order quantity: 1 unit of 5MG

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B3000-SP-B 1 each
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Insert for 1x15ml Tube 17x100mm
CEN1022 EACH
EUR 136.8

Hettich Insert for 1x25ml Tube 17x100mm
CEN0333 EACH
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MAGic Clamp™ Tube Rack, 30x15ml &20x50ml tubes (max. 4)
H1000-MR-1550 1 PC
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Kinesis 5X5M X 250uM/363uM VSD TuBING
CHR1814 EACH
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OPTIONAL HEAD FOR 8X15ML AND 8X12/13MM DIAMETER TUBES
480103 1/pk
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Description: Lab Equipment; Shakers & Mixers

HydraGreen? Safe DNA Dye, 1ml (sufficient for 400x50ml or 200x100ml agarose gels)
ACT-IDMG04 each
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10x10/15ml+20x5/7ml Drum
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TBG-NP MET 15.0X20.0X2.5 10m
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EUR 145.2

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FOB010 PK100
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ST016 1 UNIT
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430196 20/pk
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Description: Lab Cell Culture; Corning TC Dishes

Lab Jack 50x40mm Blue
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TUB6276 25MTR
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TUB6280 25MTR
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TUB6282 25MTR
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TUB6284 25MTR
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STO6406 PK100
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Sign 75x600mm Push Bar To Ope..
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ST012 1 UNIT
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ST013 1 UNIT
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Egg Shape, 25X9mm
ST014 1 UNIT
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Hi-Low Labels 33x13mm 22x90
LAB2240 EACH
EUR 51.18

Human MCP-1 ELISA kit (4X96T)
LF-EK50226 4×96T
EUR 2641.2

Mouse MCP-1 ELISA kit (4X96T)
LF-EK50672 4×96T
EUR 2641.2

Hi-Low Labels 25x13mm 16x126
LAB2242 EACH
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Rack Nalge White 109X109Mm
5972-0030 EACH
EUR 25.2

Autoclave Bag PP 634x413mm
AUT1410 PK500
EUR 215.42

600x420mm COSHH Poster
CAS0010 EACH
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Bag Specimen+Doc PE 125x140mm
BAG1200 PK100
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Bag Specimen+Doc PE 150x240mm
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Bags Red Heavy Duty 725x975mm
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MS05428R EACH
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ML01751R EACH
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ML02051R EACH
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FR03550R EACH
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FR03551R EACH
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100x100mm Toxic GHS sheet
GHSC100TO EACH
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Sign 150x125mm Danger Acid Se..
HA08507S EACH
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Sign 210x148mm Danger Trip Ha..
HA17151R EACH
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Sign 210x148mm Wear Mask Rigi..
HA27651R EACH
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FX04011R EACH
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Sign 150x450mm Fire Exit Symb..
FX04111R EACH
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Sign 150x450mm Fire Exit Symb..
FX04211R EACH
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Sign 150x450mm Fire Exit Symb..
FX04311R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04411R EACH
EUR 19.58

Sign 150x450mm Fire Exit Symb..
FX04511R EACH
EUR 19.58

Sign 150x450mm Fire Exit/Keep..
FX05111R EACH
EUR 19.58

Sign 210x148mm No Naked Light..
PH04051R EACH
EUR 10.44

Sign 210x148mm No Smoking Leg..
PH05051R EACH
EUR 10.44

H-Flex 1 33x10/12mL Adpt set/2
75003305 PK2
EUR 1086

Rotor Angle 12x15ml RB/FA
CEN2630 EACH
EUR 408

Rotor Angle 6x250ml FB ID
CEN2658 EACH
EUR 3140.4

Rotor Angle 10x50ml FA ID
CEN2668 EACH
EUR 2260.8

Rotor Angle 30x15ml RB/FA ID
CEN2672 EACH
EUR 1272

Rack 14x15mL D17mm FA 2PK
CEN2732 PK2
EUR 286.8

Rack 17x15mL D17mm FA 2PK
CEN2734 PK2
EUR 286.8

Rack 18x15mL D17mm RB 2PK
CEN2736 PK2
EUR 337.2

Rack 21x10mL D16mm RB 2PK
CEN2738 PK2
EUR 337.2

Adapter for 17.5x100mm
E5910709005 PK2
EUR 267.6

Cuvettes PS 10x10mm
FLU1100 PK100
EUR 155.37

Test Tubes 75X13Mm 5Ml Rb
RB31 PK2000
EUR 90

Sieve SS 200x0.25mm UKAS Cert.
SIE1048UKAS EACH
EUR 197.15

Rack PP Red 84x13mm Tubes
STA3220 EACH
EUR 22.8

Rack PP Red 55x16mm Tubes
STA3222 EACH
EUR 22.8

Rack PP Red 40x21mm Tubes
STA3224 EACH
EUR 16.8

Rack PP Red 32x26mm Tubes
STA3226 EACH
EUR 24

Rack PP Red 21x31mm Tubes
STA3228 EACH
EUR 24

BD Dish collagen i 100x20mm bp rt
356450 PK40
EUR 370.8

142x17mm Rotator Drum
MIX1276 EACH
EUR 416.4

Tube Holder 20x9-20mm SB3/2
MIX1964 EACH
EUR 218.4

Stuart Bottle 260x35mm
OVE3356 EACH
EUR 160.8

Stuart Bottle 230x70mm
OVE3358 EACH
EUR 244.8

Stuart Bottle 150x35mm
OVE3360 EACH
EUR 142.8

TPP Culture dish 146x21mm
TIS7106 PK100
EUR 319.2

El Paper Novablot 200x250Mm P 500
80110619 EACH
EUR 488.4

Biohazard bag Red 203x305mm
BAG1120 PK500
EUR 159.6

Biohazard bag Red 356x483mm
BAG1122 PK200
EUR 175.2

Biohazard bag Red 483x584mm
BAG1124 PK200
EUR 274.8

Biohazard bag Red 635x838mm
BAG1126 PK200
EUR 639.6

Bags Blue Heavy Duty 725x975mm
BAG2206 PK200
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210x148mm Lab Coats Must be worn
MA03151R EACH
EUR 10.44

210x148mm Wear Face Shield
MA06451R EACH
EUR 10.44

Adhering Mat Blue 300x300mm
MIX5058 EACH
EUR 138

Sign 150x450mm Nite-Glo Fire ..
FX04211L EACH
EUR 24.84

Sign 150x450mm Nite-Glo Fire ..
FX04311L EACH
EUR 24.84

Sign 150x450mm Nite-Glo Fire ..
FX04411L EACH
EUR 24.84

TBG-NP-MET 4.0X6.0X1.0 25m
TUB6268 25MTR
EUR 56.4

TBG-NP-MET 4.0X7.0X1.5 25m
TUB6270 25MTR
EUR 72

TBG-NP-MET 5.0X8.0X1.5 25m
TUB6272 25MTR
EUR 97.2

TBG-NP-MET 6.0X9.0X1.5 25m
TUB6274 25MTR
EUR 129.6

RotoBot Programmable Rotator, includes tube holders for 30x1.5ml, 8x15ml and 2x50ml
R4045 1 each
EUR 1056.2

RotoBot Programmable Rotator, includes tube holders for 30x1.5ml, 8x15ml and 2x50ml, 240V
R4045-E 1 PC
EUR 1056.2

H-Flex 1 18x15mL Adptr set/2
75003304 PK2
EUR 1086

Coverslip no.1 24x60mm
BB024060A1 PK1000
EUR 122.73

PP Labels J2000 33.02x15.24mm
LAB0156 PK1500
EUR 188.4

Labels On Roll, Red, 30X15mm
LB002R 1ROLLS, 1 UNIT
EUR 65.22

Labels On Roll, Red, 40X20mm
LB102R 1ROLLS, 1 UNIT
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30x15ml Rotator Drum
MIX1148 EACH
EUR 213.6

15x50ml Rotator Drum
MIX1158 EACH
EUR 213.6

64x14mm Rotator Drum
MIX1198 EACH
EUR 213.6

76x26mm Rotator Drum
MIX1278 EACH
EUR 362.4

60x30mm Rotator Drum
MIX1280 EACH
EUR 362.4

Tube holder 12x50ml SB3/3
MIX1966 EACH
EUR 264

Tube Holder 63x12mm SB3/4
MIX1968 EACH
EUR 288

Riffle Box StSt 12x13mm
SIE1332 EACH
EUR 1152.84

Rack PP Blue 60x16mm Tubes
STA3212 EACH
EUR 36.6

Rack PP Blue 40x21mm Tubes
STA3214 EACH
EUR 21.6

Rack PP Blue 32x26mm Tubes
STA3216 EACH
EUR 30

Rack PP Blue 21x31mm Tubes
STA3218 EACH
EUR 22.8

Select Tube 3ml 55x11mm PP
TUB0098 PK4000
EUR 205.2

Select Tube 3.5ML 75x12mm Ps
TUB0105 PK3000
EUR 136.8

Select Tube 3.5ml 75x12mm PP
TUB0106 PK2500
EUR 121.2

Injector Jet 4x160mm
WAS6138 EACH
EUR 30.03

Injector Jet 6x200mm
WAS6156 EACH
EUR 47

Injector Jet 6x220mm
WAS6158 EACH
EUR 47

Injector Jet 6x240mm
WAS6160 EACH
EUR 47

Nunc 12ml Tube 100x15mm with Cap
343141 PK500
EUR 219.6

Filter Paper No1 75X100mm
FIL2042 PK500
EUR 79.2

Tile Spotting PPR 117X95mm
TIL1010 PK10
EUR 50.4

We assessed the association between five miR-SNP in the 3 ‘translated regions ( 3 ‘ – UTR) of RYR 3 (rs1044129), KIAA042 3 (rs105 3 667), C14orf101 (rs4901706), GOLGA7 < / i> (rs11 3 3 7), and KRT81 (rs 3 660) and breast cancer risk ( BC).