To evaluate the potential effects Ankaferd Blood Stopper (ABS) and oxytocin (OT) in an experimental model of endometriosis, 18 female Sprague Dawley rats were used in this study. The animals were randomly divided into three groups after surgical induction of endometriosis: group 1: control group (isotonic saline, 1 mL / kg / day, intramuscular, n = 6); Group 2: PL group (OT, 80 U / kg / day, intramuscular, n = 6); group 3 : a group of ABS (ABS, 1.5 mL / kg / day, intraperitoneal, n = 6). Each group was treated for four weeks (twice per week).

Endometriosis explant volume is measured in biopsy samples for histopathological analysis. Vascular endothelial growth factor (VEGF), monocytes chemotactic protein level -1 (MCP-1) and tumor necrosis factor (TNF-α) measured in plasma and peritoneal fluid. endometriosis explants volume significantly decreased after administration of OT (P <0.0001). Epithelial score was significantly decreased in both treatment groups compared with the control group (P <0.05). TUNEL immunohistochemistry showed more changes in endometriosis focus apoptosis (epithelial gland and surrounding tissue) in the PL group than the control group (P <0.05).

The level of VEGF, MCP-1 and TNF-α were significantly reduced in the OT group (P <0.05), whereas no significant change in the protein to levels found in the group of ABS-applied. Results showed that OT has a greater potential as a therapeutic agent in experimentally induced peritoneal endometriosis, in which the ABS, which is a modulator of VEGF, appear to act through different mechanisms to demonstrate palliative effect in a mouse model of peritoneal endometriosis.

The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model
The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model

Sphingosine 1-phosphate / microRNA-1249-5p / MCP-1 axis is involved in the inflammation associated macrophage fatty liver injury in mice

monocytes chemotactic protein -1 (MCP-1) is one of the most representative inflammatory cytokines, and has proven to markedly increased in liver injury and sphingosine 1-phosphate (S1P) -treated macrophages. However, microRNAs (miRNAs) are targeting MCP-1 and the role of miRNA / MCP-1 axis in S1P-mediated liver inflammation remains unknown. Here we show that the expression of MCP-1 increased in the liver and macrophages isolated rat heart MCDHF. In addition, there is a positive correlation between the degree of hepatic S1P and MCP-1.

We then predict the MCP-1 targeting miRNAs with bioinformatics analyzes and miRNA-1249-5p select (mir-1249-5p) from the intersection of database TargetScan and down-regulated miRNAs in the liver injured. S1P significantly up-regulate the expression of MCP-1 and miR-1249-5p decrease in expression in macrophages. MiR-1249-5p directly target of 3 ‘- UTR of MCP-1 and negatively regulates the expression of the S1P-treated macrophages. Mir-1249-5p agomir administration decreased liver MCP-1 levels and attenuates hepatic inflammation in mice MCDHF.

Protein – protein interaction network by displaying STRING that S1P system is closely related to MCP-1 / CCR2 axis in inflammatory tissue. In conclusion, we characterize the important role of miR-1249-5p in negatively regulates the expression of MCP-1 in vitro and in vivo, which can open up new perspectives for pharmacological treatment of heart disease. This article is protected by copyright. All rights reserved.Single nucleotide polymorphisms in miRNA binding sites (mir-SNP) that are associated with cancer risk.

(RS)-MCPG

B6265-25 25 mg
EUR 278
Description: mGluR antagonist

(RS)-MCPG

B6265-5 5 mg
EUR 91
Description: mGluR antagonist

(RS)-MCPG

B6265-5.1 10 mM (in 1mL DMSO)
EUR 250.8

(RS)-MCPG

B6265-50 50 mg
EUR 490
Description: mGluR antagonist

(S)-MCPG

B6266-10 10 mg
EUR 146
Description: mGluR antagonist

(S)-MCPG

B6266-25 25 mg
EUR 304
Description: mGluR antagonist

(S)-MCPG

B6266-5 5 mg
EUR 106
Description: mGluR antagonist

(S)-MCPG

B6266-50 50mg
EUR 523
Description: mGluR antagonist

(RS)-MCPG

555671 100.0mg
EUR 950

(RS)-MCPG

HY-100371 100mg
EUR 1135.2

(S)-MCPG

HY-100406 5mg
EUR 159.6

(S)-MCPG

M199718 1g
EUR 7600
Description: 150145-89-4

(RS)-MCPG

M264743 100mg
EUR 3000
Description: 146669-29-6

(RS)-MCPG

T3479-10mg 10mg Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-1g 1g Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-1mg 1mg Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-50mg 50mg Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-5mg 5mg Ask for price
Description: (RS)-MCPG

(S)-MCPG

T13452-10mg 10mg Ask for price
Description: (S)-MCPG

(S)-MCPG

T13452-1g 1g Ask for price
Description: (S)-MCPG

(S)-MCPG

T13452-1mg 1mg Ask for price
Description: (S)-MCPG

(S)-MCPG

T13452-50mg 50mg Ask for price
Description: (S)-MCPG

(S)-MCPG

T13452-5mg 5mg Ask for price
Description: (S)-MCPG

(RS)-MCPG

MBS579609-10mg 10mg
EUR 180

(RS)-MCPG

MBS579609-25mg 25mg
EUR 275

(RS)-MCPG

MBS579609-2mg 2mg
EUR 145

(RS)-MCPG

MBS579609-50mg 50mg
EUR 410

(RS)-MCPG

MBS579609-5mg 5mg
EUR 160

(S)-MCPG

MBS3844992-100mg 100mg
EUR 825

(S)-MCPG

MBS3844992-10mg 10mg
EUR 200

(S)-MCPG

MBS3844992-50mg 50mg
EUR 440

(S)-MCPG

MBS3844992-5mg 5mg
EUR 155

(S)-MCPG

MBS3844992-5x100mg 5x100mg
EUR 3695

(RS)-MCPG

MBS3845259-100mg 100mg
EUR 910

(RS)-MCPG

MBS3845259-10mg 10mg
EUR 210

(RS)-MCPG

MBS3845259-50mg 50mg
EUR 485

(RS)-MCPG

MBS3845259-5mg 5mg
EUR 165

(RS)-MCPG

MBS3845259-5x100mg 5x100mg
EUR 4085

(RS)-MCPG

MBS3607307-10mg 10mg
EUR 245

(RS)-MCPG

MBS3607307-25mg 25mg
EUR 340

(RS)-MCPG

MBS3607307-2mg 2mg
EUR 200

(RS)-MCPG

MBS3607307-50mg 50mg
EUR 475

(RS)-MCPG

MBS3607307-5mg 5mg
EUR 220

(S)-MCPG

MBS5754201-200mg 200mg
EUR 1055

(S)-MCPG

MBS5754201-5x200mg 5x200mg
EUR 4610

MCPG (sodium)

HY-103570 Get quote Ask for price
Description: MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) [1].

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 126
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-100 100mg
EUR 900
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-25 25mg
EUR 278
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-5 5mg
EUR 91
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 490
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

T23270-10mg 10mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-1g 1g Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-1mg 1mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-50mg 50mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-5mg 5mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

MBS5757736-50mg 50mg
EUR 1140

(RS)-MCPG disodium salt

MBS5757736-5x50mg 5x50mg
EUR 4970

SIN-1, 25x1mg

00221-1-1 EA
EUR 120

DID (DIIC18(5)), 5x1mg

60014-5mg 5MG
EUR 130
Description: N/A

DID (DIIC18(5)), 5x1mg

60014-5mg-1 EA
EUR 130

DIR (DIIC18(7)), 5x1mg

60017-5mg 5MG
EUR 172
Description: N/A

DIR (DIIC18(7)), 5x1mg

60017-5mg-1 EA
EUR 172

BAPTA, AM ester: (20x1mg)

50000-1-1 EA
EUR 310

Proteinase K, 1g (10x100mg)

PC0712-1g each Ask for price

SynaptoRed™C2 5x1mg

70027 5ST
EUR 463
Description: N/A

SynaptoRed™C2 5x1mg

70027-1 PK
EUR 463

SynaptoRed™C1 5x1mg

70041 5ST
EUR 356
Description: N/A

SynaptoRed™C1 5x1mg

70041-1 PK
EUR 356

SynaptoRed™C2M 5x1mg

70019-1 EA
EUR 463

SynaptoGreen™C4 5x1mg

70022 5ST
EUR 463
Description: N/A

SynaptoGreen™C4 5x1mg

70022-1 EA
EUR 463

SynaptoGreen™C3 5x1mg

70026 5ST
EUR 356
Description: N/A

SynaptoGreen™C3 5x1mg

70026-1 PK
EUR 356

SynaptoGreen™C1 5x1mg

70043 5ST
EUR 356
Description: N/A

SynaptoGreen™C1 5x1mg

70043-1 PK
EUR 356

SynaptoGreen™C2 5x1mg

70045 5ST
EUR 356
Description: N/A

SynaptoGreen™C2 5x1mg

70045-1 PK
EUR 356

SynaptoGreen™C5 5x1mg

70047 5ST
EUR 356
Description: N/A

SynaptoGreen™C5 5x1mg

70047-1 PK
EUR 356

SynaptoGreen™ C18 5x1mg

70049 5ST
EUR 534
Description: N/A

SynaptoGreen™ C18 5x1mg

70049-1 PK
EUR 534

BD collagen i rat tail bulk 10x100mg - PK10

356236 PK10
EUR 1939.95

Bovine Serum Albumin, CF®594 Conjugate, 5x1mg

20290 5x1mg
EUR 224
Description: BSA from bovine serum (Cow; Bos taurus)

Bovine Serum Albumin, CF®594 Conjugate, 5x1mg

20290-1 EA
EUR 224

Bovine Serum Albumin, CF®680 Conjugate, 5x1mg

20292 5x1mg
EUR 251
Description: BSA from bovine serum (Cow; Bos taurus)

Bovine Serum Albumin, CF®680 Conjugate, 5x1mg

20292-1 EA
EUR 251

Probenecid, Sodium Salt *Water Soluble*, 10x77mg

50027-1 PK
EUR 239

Bovine Serum Albumin, CF®488A Conjugate, 5x1mg

20289 5x1mg
EUR 224
Description: BSA from bovine serum (Cow; Bos taurus)

Bovine Serum Albumin, CF®488A Conjugate, 5x1mg

20289-1 EA
EUR 224

Bovine Serum Albumin, CF®640R Conjugate, 5x1mg

20291 5x1mg
EUR 224
Description: BSA from bovine serum (Cow; Bos taurus)

Bovine Serum Albumin, CF®640R Conjugate, 5x1mg

20291-1 EA
EUR 224

Mix-n-Stain™ Maxi CF®555 Antibody Labeling Kit, 1x1mg labeling

92406 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®555 Antibody Labeling Kit, 1x1mg labeling

92406-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®568 Antibody Labeling Kit, 1x1mg labeling

92407 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®568 Antibody Labeling Kit, 1x1mg labeling

92407-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®594 Antibody Labeling Kit, 1x1mg labeling

92408 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®594 Antibody Labeling Kit, 1x1mg labeling

92408-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®633 Antibody Labeling Kit, 1x1mg labeling

92409 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®633 Antibody Labeling Kit, 1x1mg labeling

92409-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®647 Antibody Labeling Kit, 1x1mg labeling

92410 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®647 Antibody Labeling Kit, 1x1mg labeling

92410-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®350 Antibody Labeling Kit, 1x1mg labeling

92420 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®350 Antibody Labeling Kit, 1x1mg labeling

92420-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®680 Antibody Labeling Kit, 1x1mg labeling

92422 -
EUR 602
Description: N/A

Mix-n-Stain™ Maxi CF®680 Antibody Labeling Kit, 1x1mg labeling

92422-1 KT
EUR 602

Mix-n-Stain™ Maxi CF®750 Antibody Labeling Kit, 1x1mg labeling

92423 -
EUR 602
Description: N/A

Mix-n-Stain™ Maxi CF®750 Antibody Labeling Kit, 1x1mg labeling

92423-1 KT
EUR 602

Mix-n-Stain™ Maxi CF®770 Antibody Labeling Kit, 1x1mg labeling

92424 -
EUR 602
Description: N/A

Mix-n-Stain™ Maxi CF®770 Antibody Labeling Kit, 1x1mg labeling

92424-1 KT
EUR 602

Mix-n-Stain™ Maxi CF®405M Antibody Labeling Kit, 1x1mg labeling

92404 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®405M Antibody Labeling Kit, 1x1mg labeling

92404-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®488A Antibody Labeling Kit, 1x1mg labeling

92405 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®488A Antibody Labeling Kit, 1x1mg labeling

92405-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®405S Antibody Labeling Kit, 1x1mg labeling

92421 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®405S Antibody Labeling Kit, 1x1mg labeling

92421-1 KT
EUR 577

Mix-n-Stain™ Maxi CF®405L Antibody Labeling Kit, 1x1mg labeling

92454 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi CF®405L Antibody Labeling Kit, 1x1mg labeling

92454-1 KT
EUR 577

Mix-n-Stain™ Maxi FITC Antibody Labeling Kit, 1x1mg labeling

92411 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi FITC Antibody Labeling Kit, 1x1mg labeling

92411-1 KT
EUR 577

Mix-n-Stain™ Maxi Cyanine 555 Antibody Labeling Kit, 1x1mg labeling

92415 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi Cyanine 555 Antibody Labeling Kit, 1x1mg labeling

92415-1 KT
EUR 577

Mix-n-Stain™ Maxi Cyanine 647 Antibody Labeling Kit, 1x1mg labeling

92419 -
EUR 577
Description: N/A

Mix-n-Stain™ Maxi Cyanine 647 Antibody Labeling Kit, 1x1mg labeling

92419-1 KT
EUR 577

Accuris™ Class E2, Calibration set for Analytical Balances, 6 pcs: 1x100mg, 1x10g, 2x20g, 1x50g, 1x100g

W1101-6-100 1 PC
EUR 658.89

Anti-Human MCP-1 (9G10) Antibody

MBS4158343-01mg 0.1mg
EUR 685

Anti-Human MCP-1 (9G10) Antibody

MBS4158343-5x01mg 5x0.1mg
EUR 2820

hybex™ Media storage bottle, STARTER PACK (GL45) blue cap (Includes 2x100ml, 3x250ml, 3x500ml and 2x1000ml)

B3000-SP-B 1 each
EUR 151.1

Insert for 1x15ml Tube 17x100mm - EACH

CEN1022 EACH
EUR 153.9

Ficoll Paque Premium 6x500Ml - 6x500ML

17544203 6x500ML
EUR 984.15

Hettich Insert for 1x25ml Tube 17x100mm - EACH

CEN0333 EACH
EUR 153.9

MAGic Clamp™ Tube Rack, 30x15ml &20x50ml tubes (max. 1)

H1000-MR-1550 1 PC
EUR 181.07

Cyclin B2(X29.2), 1mg/mL

BNUM3059-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Cyclin B2(X29.2), 0.2mg/mL

BNUB3059-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Cyclin B2(X29.2), 0.2mg/mL

BNUB3059-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

25ML TE BUFFER 100X - 25ML

NAT1204 25ML
EUR 64.8

OPTIONAL HEAD FOR 8X15ML AND 8X12/13MM DIAMETER TUBES

480103 1/pk
EUR 75.6
Description: Lab Equipment; Shakers & Mixers

Kinesis 5X5M X 250uM/363uM VSD TuBING - EACH

CHR1814 EACH
EUR 496.8

HydraGreen™ Safe DNA Dye, 1ml (sufficient for 400x50ml or 200x100ml agarose gels)

ACT IDMG04
EUR 135.53

HydraGreen? Safe DNA Dye, 1ml (sufficient for 400x50ml or 200x100ml agarose gels)

ACT-IDMG04 each
EUR 247.2

Amphotericin B 100X - 20ml

LM-A4109/20 20ml
EUR 5.61

Amphotericin B 100X - 50ml

LM-A4109/50 50ml
EUR 11.44

Sign 210x148mm Do Not Use Mob..

PH01051S EACH
EUR 5.39

Sign 210x148mm No Food Or Dri..

PH03351S EACH
EUR 5.4

RotoBot Programmable Rotator, includes tube holders for 30x1.5ml, 8x15ml and 2x50ml

R4045 1 each
EUR 1087.89

RotoBot Programmable Rotator, includes tube holders for 30x1.5ml, 8x15ml and 2x50ml, 240V

R4045-E 1 PC
EUR 1087.89

Bags Ldpe 229X457Mm - PK50

6255-0918 PK50
EUR 105.3

Basket 145x280mm - EACH

WAS3106 EACH
EUR 74.25

10x10/15ml+20x5/7ml Drum - EACH

MIX1196 EACH
EUR 240.3

Accuris Probe One-Step RT-qPCR Kit, No ROX, 2500 reactions (1x25ml, 2x1.25ml)

PR2121-N-25BLK 1 each
EUR 2775.85

Accuris Probe One-Step RT-qPCR Kit, No ROX, 5000 reactions (1x50ml, 4x1.25ml)

PR2121-N-50BLK 1 each
EUR 4928.55

SCF525 (50x50mm)

2008061 each
EUR 353.76

EDTA SOL. (0.5M) pH8.0 4x100ML

IB70185 -
EUR 88.53
Description: (MADE FROM (4) IB70184)

RotoBot Mini Programmable Rotator, includes tube holders for 12x1.5ml, 2x15ml and 2x50ml

R4040 1 each
EUR 708.54

RotoBot Mini Programmable Rotator, includes tube holders for 12x1.5ml, 2x15ml and 2x50ml, 240V

R4040-E 1 PC
EUR 708.54

Bench Mats 300X300mm - PK10

EDU1010 PK10
EUR 32.4

Sign 210x148mm Do Not Use Mob.. - EACH

PH01051R EACH
EUR 11.75

Sign 210x148mm No Food Or Dri.. - EACH

PH03351R EACH
EUR 13.23

Lab Jack 100x100mm Blue - EACH

JAC1000 EACH
EUR 187.65

Lab Jack 150x150mm Blue - EACH

JAC1004 EACH
EUR 248.4

Lab Jack 200x200mm Blue - EACH

JAC1008 EACH
EUR 311.85

Lab Jack 200x230mm Blue - EACH

JAC1012 EACH
EUR 379.35

Lab Jack 320x260mm Blue - EACH

JAC1013 EACH
EUR 846.45

DISH,60X15MM,GRID,TCT,PS,S,BK,20/500

430196 20/pk
EUR 288
Description: Lab Cell Culture; Corning TC Dishes

Accuris SYBR Green One-Step RT-qPCR Kit, No ROX, 2500 reactions (1x25ml, 2x1.25ml)

PR2120-N-25BLK 1 each
EUR 2775.85

Accuris SYBR Green One-Step RT-qPCR Kit, No ROX, 5000 reactions (1x50ml, 4x1.25ml)

PR2120-N-50BLK 1 each
EUR 4928.55

Retort Rod SS 500x10mm - EACH

STA1120 EACH
EUR 33.75

Adapter for 11x75-100mm - PK2

E5910704003 PK2
EUR 279.45

Durx 670 Wipes 230x230mm - PK300

CLE4012 PK300
EUR 59.4

Durx 770 Wipes 230x230mm - PK300

CLE4014 PK300
EUR 157.95

Pipette Jar 514X165Mm - EACH

5242-0040 EACH
EUR 271.35

Pipette Jar 162x650mm - EACH

WAS3104 EACH
EUR 163.35

Sign 150x450mm Fire Exit Symb..

FX04111R EACH
EUR 16.16

Sign 150x450mm Fire Exit Symb..

FX04211R EACH
EUR 16.16

Sign 150x450mm Fire Exit Symb..

FX04311R EACH
EUR 16.16

Sign 150x450mm Fire Exit Symb..

FX04411R EACH
EUR 16.16

Sign 150x450mm Fire Exit Symb..

FX04511R EACH
EUR 16.16

Sign 300x300mm No Smoking/Dri..

MS05428S EACH
EUR 11.85

Sign 210x148mm Do Not Drink R.. - EACH

PH00251R EACH
EUR 11.75

Test Tube 16x100mm - PK100

3840/16X100 PK100
EUR 74.25

150x50mm Pull - Rigid - EACH

FX05312R EACH
EUR 8.82

150x50mm Push - Rigid - EACH

FX05512R EACH
EUR 8.82

50x30mm Well Bar Set, per set

IW-P115 -
EUR 575

TBG-NP MET 15.0X20.0X2.5 10m - 10MTR

TUB6290 10MTR
EUR 114.75

Hybond LFP 0.2 PVDF 200x200mm - PK10

10600060 PK10
EUR 390.15

Sign 150x450mm Nite-Glo Fire ..

FX04311L EACH
EUR 20.49

Sign 150x450mm Nite-Glo Fire ..

FX04411L EACH
EUR 20.49

Sign 300x500mm No Smoking/No .. - EACH

MS05529R EACH
EUR 36.72

We assessed the association between five miR-SNP in the 3 ‘translated regions ( 3 ‘ – UTR) of RYR 3 (rs1044129), KIAA042 3 (rs105 3 667), C14orf101 (rs4901706), GOLGA7 < / i> (rs11 3 3 7), and KRT81 (rs 3 660) and breast cancer risk ( BC).