cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg

QP12522-50mg 50mg
EUR 3655

Recombinant other Urease Protein, Untagged, E.coli-50mg

QP10907-50mg 50mg
EUR 1043

Recombinant Multi Species ACTH Protein, Untagged, -50mg

QP10950-50mg 50mg
EUR 553

Recombinant other Atosiban Protein, Untagged, E.coli-50mg

QP11102-50mg 50mg
EUR 218

Recombinant other Terlipressin Protein, Untagged, E.coli-50mg

QP13723-50mg 50mg
EUR 363

Recombinant Human CTRB1 Protein, Untagged, E.coli-50mg

QP10565-50mg 50mg
EUR 563

Recombinant Yeast IDH1 Protein, Untagged, Yeast-50mg

QP10670-50mg 50mg
EUR 1043

Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg

QP12314-50mg 50mg
EUR 201

Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg

QP12317-50mg 50mg
EUR 363

Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg

QP10897-50mg 50mg
EUR 962

Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg

QP10899-50mg 50mg
EUR 563

Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg

QP10544-50mg 50mg
EUR 517

Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg

QP12316-50mg 50mg
EUR 363

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg

QP11479-50mg 50mg
EUR 926

(RS)-MCPG

B6265-10 10 mg
EUR 248

(RS)-MCPG

B6265-100 100 mg
EUR 1497

(RS)-MCPG

B6265-25 25 mg
EUR 502

(RS)-MCPG

B6265-5 5 mg
EUR 195

(RS)-MCPG

B6265-5.1 10 mM (in 1mL DMSO)
EUR 209

(RS)-MCPG

B6265-50 50 mg
EUR 846

(S)-MCPG

B6266-10 10 mg
EUR 176

(S)-MCPG

B6266-25 25 mg
EUR 350

(S)-MCPG

B6266-5 5 mg
EUR 116

(RS)-MCPG

HY-100371 100mg
EUR 946

(S)-MCPG

HY-100406 5mg
EUR 133

DiA: (50mg)

60013 50MG
EUR 210
Description: Minimum order quantity: 1 unit of 50MG

L-NMMA: (50mg)

00224 25MG
EUR 207
Description: Minimum order quantity: 1 unit of 25MG

Gentamicin, 50mg/ml

CA003-001 10ml
EUR 91

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 302

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 1114

DiOC14(3), hydroxyethanesulfonate: (50mg)

60012 50MG
EUR 153
Description: Minimum order quantity: 1 unit of 50MG

Biotin-12, SE: (50mg)

90083 50MG
EUR 193
Description: Minimum order quantity: 1 unit of 50MG

Kanamycin solution (50mg/ml)

MN800A-1 20 ml
EUR 127
  • Category: Minicircle Technology

DiD (or DiIC18(5)): (50mg)

60014 50MG
EUR 161
Description: Minimum order quantity: 1 unit of 50MG

Acyclovir (Acycloguanosine)

A090-50MG 50 mg
EUR 127

Atovaquone

A099-50MG 50 mg
EUR 239

Actinomycin D

1036-50MG
EUR 533

Camptothecin

1039-50MG
EUR 153

Sulfo-Cyanine7.5 dicarboxylic acid, 50 mg

1382-50mg 50 mg
EUR 921

BDP R6G azide, 50 mg

1476-50mg 50 mg
EUR 501

sulfo-Cyanine7 dicarboxylic acid, 50 mg

1497-50mg 50 mg
EUR 921

Cyanine7 dicarboxylic acid, 50 mg

1512-50mg 50 mg
EUR 501

IGF-I, human recombinant

4119-50MG
EUR 4220

R³ IGF-1, human recombinant

4216-50MG
EUR 3470

Bleomycin A5 hydrochloride

B004-50MG 50 mg
EUR 397

Bleomycin sulfate USP

B005-50MG 50 mg
EUR 575

Brefeldin A

B012-50MG 50 mg
EUR 335

Bithionol

B035-50MG 50 mg
EUR 72

Bleomycin

B053-50MG 50 mg
EUR 708

Biapenem

B080-50MG 50mg
EUR 198

Daunorubicin hydrochloride

D001-50MG 50 mg
EUR 400

Daptomycin

D024-50MG 50 mg
EUR 178

Dihydrozeatin (DHZ)

D071-50MG 50 mg
EUR 186

Dihydrotanshinone I

D078-50MG 50 mg
EUR 394

Dalbavancin Hydrochloride

D092-50MG 50mg
EUR 380

Ertapenem sodium EvoPure®

E008-50MG 50 mg
EUR 277

Enniatin

E039-50MG 50 mg
EUR 1082

Everolimus

E058-50MG 50 mg
EUR 236

Embelin

E063-50MG 50 mg
EUR 252

Emodin

E064-50MG 50 mg
EUR 112

Epigallocatechin gallate

E065-50MG 50 mg
EUR 84

Aztreonam

A017-50MG 50 mg
EUR 115

Horseradish Peroxidase Antibody

abx022688-50mg 50 mg
EUR 954
  • Shipped within 5-10 working days.

Aldolase (Rabbit Muscle) Antibody

abx022821-50mg 50 mg
EUR 1052
  • Shipped within 5-10 working days.

Carbonic Anhydrase II (CA2) Antibody

abx022828-50mg 50 mg
EUR 857
  • Shipped within 5-10 working days.

Elastase Antibody

abx022830-50mg 50 mg
EUR 857
  • Shipped within 5-10 working days.

Glucose Oxidase Antibody

abx022832-50mg 50 mg
EUR 1052
  • Shipped within 5-10 working days.

Papain (Carica papaya) Antibody

abx022844-50mg 50 mg
EUR 899
  • Shipped within 5-10 working days.

Irinotecan

abx188740-50mg 50 mg
EUR 314
  • Shipped within 1-2 weeks.

(R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane

abx180110-50mg 50 mg
EUR 398
  • Shipped within 1-2 weeks.

Cafenstrole

abx185370-50mg 50 mg
EUR 606
  • Shipped within 1-2 weeks.

(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

abx186093-50mg 50 mg
EUR 300
  • Shipped within 1-2 weeks.

dabigatran

abx186421-50mg 50 mg
EUR 425
  • Shipped within 1-2 weeks.

SL-01

abx076822-50mg 50 mg
EUR 272
  • Shipped within 5-12 working days.

Leflunomide

abx076826-50mg 50 mg
EUR 230
  • Shipped within 5-12 working days.

Auranofin

abx076835-50mg 50 mg
EUR 272
  • Shipped within 5-12 working days.

Chicken IgY Protein

abx060688-50mg 50 mg
EUR 551
  • Shipped within 5-10 working days.

Cefepime

C008-50MG 50 mg
EUR 438

Cefprozil

C017-50MG 50 mg
EUR 511

Rabbit Anti-Human IgM (u chain)

C020210-50mg 50mg
EUR 6015

Goat Anti-Human IgM(u chain)

C020213-50mg 50mg
EUR 2635

Goat Anti-Human IgG FC

C020220-50mg 50mg
EUR 6015

Rabbit Anti-Human IgG FC

C020221-50mg 50mg
EUR 6015

Goat Anti-Human IgG Fab

C020233-50mg 50mg
EUR 2635

Goat Anti-Human IgG (γ chain)

C020234-50mg 50mg
EUR 2635

Rabbit Anti-Human IgG (γ chain)

C020235-50mg 50mg
EUR 2635

Goat Anti-Human IgG F(AB)2

C020238-50mg 50mg
EUR 2635

Goat Anti-Tree shrew IgG(H+L)

C020239-50mg 50mg
EUR 2635

Rabbit Anti-Human IgG F(AB)2

C020240-50mg 50mg
EUR 2635

Goat Anti-Human IgA

C020242-50mg 50mg
EUR 2635

Clindamycin Hydrochloride

C035-50MG 50 mg
EUR 127

Clindamycin Phosphate

C036-50MG 50 mg
EUR 119

Camptothecin (Camptotheca acuminata)

C070-50MG 50 mg
EUR 77

Cefotiam Dihydrochloride

C095-50MG 50 mg
EUR 144

Camptothecin (Mappia foetida)

C145-50MG 50 mg
EUR 77

Camptothecin sodium

C146-50MG 50 mg
EUR 80

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.