cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

Recombinant other Exenatide Protein, Untagged, E.coli-50mg

QP11816-50mg 50mg
EUR 2358

Recombinant Bovine HTF Protein, Untagged, E.coli-50mg

QP12351-50mg 50mg
EUR 155

Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg

QP12522-50mg 50mg
EUR 3655

Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg

QP10544-50mg 50mg
EUR 517

Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg

QP10897-50mg 50mg
EUR 962

Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg

QP10899-50mg 50mg
EUR 563

Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg

QP12314-50mg 50mg
EUR 201

Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg

QP12317-50mg 50mg
EUR 363

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg

QP11479-50mg 50mg
EUR 926

Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg

QP12316-50mg 50mg
EUR 363

(RS)-MCPG

HY-100371 100mg
EUR 946

(S)-MCPG

HY-100406 5mg
EUR 133

(RS)-MCPG

B6265-10 10 mg
EUR 248

(RS)-MCPG

B6265-100 100 mg
EUR 1497

(RS)-MCPG

B6265-25 25 mg
EUR 502

(RS)-MCPG

B6265-5 5 mg
EUR 195

(RS)-MCPG

B6265-5.1 10 mM (in 1mL DMSO)
EUR 209

(RS)-MCPG

B6265-50 50 mg
EUR 846

(S)-MCPG

B6266-10 10 mg
EUR 176

(S)-MCPG

B6266-25 25 mg
EUR 350

(S)-MCPG

B6266-5 5 mg
EUR 116

DiA: (50mg)

60013 50MG
EUR 210
Description: Minimum order quantity: 1 unit of 50MG

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 302

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 1114

Gentamicin, 50mg/ml

CA003-001 10ml
EUR 91

L-NMMA: (50mg)

00224 25MG
EUR 207
Description: Minimum order quantity: 1 unit of 25MG

DiOC14(3), hydroxyethanesulfonate: (50mg)

60012 50MG
EUR 153
Description: Minimum order quantity: 1 unit of 50MG

Biotin-12, SE: (50mg)

90083 50MG
EUR 193
Description: Minimum order quantity: 1 unit of 50MG

Kanamycin solution (50mg/ml)

MN800A-1 20 ml
EUR 127

DiD (or DiIC18(5)): (50mg)

60014 50MG
EUR 161
Description: Minimum order quantity: 1 unit of 50MG

SAHA (Vorinostat )

P004-50MG 50MG
EUR 119
Description: CAS: 149647-78-9

HPA (Hexyl-4-pentynoic acid )

P008-50MG 50MG
EUR 311
Description: CAS: 96017-59-3

5-Azacytidine

P012-50MG 50MG
EUR 86
Description: CAS: 320-67-2

Decitabine

P015-50MG 50MG
EUR 539
Description: CAS: 2353-33-5

BRL-50481

P020-50MG 50 mg
EUR 441
Description: CAS: 433695-36-4

Xanthohumol

P021-50MG 50MG
EUR 1001
Description: CAS: 6754-58-1

Quercetin dihydrate EvoPure®

Q002-50MG 50 mg
EUR 138

Salinomycin sodium

S002-50MG 50 mg
EUR 102

Sulbactam

S010-50MG 50 mg
EUR 272

Synercid

S018-50MG 50mg
EUR 730

Sancycline hydrochloride

S076-50MG 50 mg
EUR 440

α-Mangostin

M076-50MG 50 mg
EUR 523

γ-Mangostin

M077-50MG 50 mg
EUR 967

Miltefosine

M085-50MG 50 mg
EUR 95

Mosapride Citrate

M099-50MG 50mg
EUR 371

Natamycin

N002-50MG 50 mg
EUR 70

Nigericin sodium

N015-50MG 50 mg
EUR 563

Naftifine hydrochloride

N047-50MG 50 mg
EUR 138

Neochlorogenic acid

N050-50MG 50 mg
EUR 617

Nitazoxanide

N052-50MG 50 mg
EUR 213

Neratinib

N067-50MG 50mg
EUR 110

Lamivudine

L019-50MG 50 mg
EUR 282

Lasalocid Sodium

L026-50MG 50 mg
EUR 119

Lenvatinib

L051-50MG 50mg
EUR 238

Meropenem USP

M002-50MG 50 mg
EUR 171

Mitoxantrone hydrochloride

M010-50MG 50 mg
EUR 129

Mycophenolic Acid

M012-50MG 50 mg
EUR 73

Mupirocin

M022-50MG 50 mg
EUR 276

Pristinamycin

P018-50MG 50mg
EUR 889

Pneumocandin B0

P092-50MG 50 mg
EUR 229

Permethrin

P106-50MG 50 mg
EUR 73

Oritavancin Diphosphate

O032-50MG 50mg
EUR 481

Flucloxacillin sodium

F009-50MG 50 mg
EUR 312

Faropenem sodium

F016-50MG 50mg
EUR 242

Fidaxomicin

F025-50MG 50 mg
EUR 105

Ganciclovir

G002-50MG 50 mg
EUR 190

Rucaparib camsylate

R044-50MG 50mg
EUR 273

Rocuronium Bromide

R045-50MG 50mg
EUR 102

Indomethacin morpholinylamide

I039-50MG 50 mg
EUR 227

Ertapenem sodium EvoPure®

E008-50MG 50 mg
EUR 277

Daunorubicin hydrochloride

D001-50MG 50 mg
EUR 400

Daptomycin

D024-50MG 50 mg
EUR 178

Dihydrozeatin (DHZ)

D071-50MG 50 mg
EUR 186

Dihydrotanshinone I

D078-50MG 50 mg
EUR 394

Dalbavancin Hydrochloride

D092-50MG 50mg
EUR 380

Embelin

E063-50MG 50 mg
EUR 252

Emodin

E064-50MG 50 mg
EUR 112

Epigallocatechin gallate

E065-50MG 50 mg
EUR 84

Enniatin

E039-50MG 50 mg
EUR 1082

Everolimus

E058-50MG 50 mg
EUR 236

Telithromycin

T015-50MG 50 mg
EUR 291

Tedizolid

T117-50MG 50mg
EUR 481

Tedizolid Phosphate

T118-50MG 50mg
EUR 180

Tipiracil Hydrochloride

T121-50MG 50mg
EUR 340

Tolvaptan

T125-50MG 50mg
EUR 429

Tenofovir Alafenamide

T128-50MG 50mg
EUR 144

Phenyl b-D-thioglucopyranoside

GC0722-50MG 50 mg
EUR 70

b-D-Allopyranose

GC0862-50MG 50 mg
EUR 61

5-Bromo-4-chloro-3-indolyl b-D-xylopyranoside

GC1526-50MG 50 mg
EUR 94

Methyl N-acetyl-alpha-D-glucosaminide

GC2856-50MG 50 mg
EUR 142

Maltohexaose

GC2935-50MG 50 mg
EUR 86

5-Bromo-4-chloro-3-indolyl b-D-galactopyranoside

GC3237-50MG 50 mg
EUR 54

XTT sodium salt

GC5281-50MG 50 mg
EUR 142

Quercetin 3-b-D-glucoside

GC9169-50MG 50 mg
EUR 114

Spiperone hydrochloride

GE2928-50MG 50 mg
EUR 154

AEBSF hydrochloride

GE4678-50MG 50 mg
EUR 114

5-Methyl-2'-deoxycytidine

GE5158-50MG 50 mg
EUR 75

Asiaticoside

GC7829-50MG 50 mg
EUR 344

Stevioside

GC8309-50MG 50 mg
EUR 367

Trifluridine

GE1913-50MG 50 mg
EUR 102

Actinomycin D

GA0481-50MG 50 mg
EUR 174

Ascomycin

GA1406-50MG 50 mg
EUR 285

Mupirocin

GA2184-50MG 50 mg
EUR 82

Flumethasone

GA2414-50MG 50 mg
EUR 70

Telithromycin

GA2425-50MG 50 mg
EUR 150

Linezolid

GA2609-50MG 50 mg
EUR 126

Brefeldin A

GA2848-50MG 50 mg
EUR 389

Doxorubicin hydrochloride

GA4969-50MG 50 mg
EUR 126

Torezolid

GA5035-50MG 50 mg
EUR 90

Pimaricin

GA5100-50MG 50 mg
EUR 50

Ribavirin

GA5462-50MG 50 mg
EUR 62

Phleomycin

GA6020-50MG 50 mg
EUR 269

Biapenem

GA6808-50MG 50 mg
EUR 78

Vinblastine sulfate

GA7194-50MG 50 mg
EUR 389

Rapamycin

GA7417-50MG 50 mg
EUR 150

Ceftibuten hydrate

GA7818-50MG 50 mg
EUR 120

Mitomycin C

GA9147-50MG 50 mg
EUR 269

Moxifloxacin hydrochloride

GA9781-50MG 50 mg
EUR 54

Ribonuclease A, DNase free

GE9871-50MG 50 mg
EUR 107

PD 98,059

GK2140-50MG 50 mg
EUR 378

Aminopterin dihydrate

GK2974-50MG 50 mg
EUR 107

Pravastatin sodium salt

GK3699-50MG 50 mg
EUR 110

alpha-Mangostin

GK4316-50MG 50 mg
EUR 269

3-Morpholinosydnonimine hydrochloride

GK4946-50MG 50 mg
EUR 200

H-8 dihydrochloride

GK6037-50MG 50 mg
EUR 252

Ro 61-8048

GK6422-50MG 50 mg
EUR 548

Cisapride monohydrate

GL0434-50MG 50 mg
EUR 229

AdipoRon hydrochloride

GL0874-50MG 50 mg
EUR 459

Mephenytoin

GL1129-50MG 50 mg
EUR 429

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

GL1507-50MG 50 mg
EUR 321

MTSSL

GL1695-50MG 50 mg
EUR 436

Tocainide hydrochloride

GL2205-50MG 50 mg
EUR 429

Thonzonium bromide

GL2255-50MG 50 mg
EUR 166

WY-14643

GL2940-50MG 50 mg
EUR 154

Compound 112254

GL3740-50MG 50 mg
EUR 459

Cyclic Pifithrin-alpha hydrobromide

GL3913-50MG 50 mg
EUR 528

Shikonin

GL5964-50MG 50 mg
EUR 269

TOFA

GL6289-50MG 50 mg
EUR 198

4-Aminophenylphosphate sodium salt

GL6836-50MG 50 mg
EUR 252

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

GK2289-50MG 50 mg
EUR 77

SC-560

GK2799-50MG 50 mg
EUR 349

Piperlongumine

GK8547-50MG 50 mg
EUR 223

Bay 11-7082

GK8638-50MG 50 mg
EUR 413

PK 11195

GL4857-50MG 50 mg
EUR 321

MnTBAP chloride

GL5377-50MG 50 mg
EUR 154

AdipoRon

GL6438-50MG 50 mg
EUR 390

Epicoprostanol

GL6737-50MG 50 mg
EUR 137

Zerumbone

GL7258-50MG 50 mg
EUR 298

GYY 4137

GL7524-50MG 50 mg
EUR 321

L-Alanyl-L-1-aminoethylphosphonic acid

GL8388-50MG 50 mg
EUR 158

Corosolic acid

GL8496-50MG 50 mg
EUR 668

MnTMPyP pentachloride

GL8780-50MG 50 mg
EUR 154

Compound 112254 hydrochloride

GL8859-50MG 50 mg
EUR 459

Ketanserin (+)-tartrate salt

GL9943-50MG 50 mg
EUR 172

Bay 60-7550

GN2518-50MG 50 mg
EUR 2582

5-(E)-(2-Bromovinyl)-2'-deoxyuridine

GN2626-50MG 50 mg
EUR 150

3'-O-Methylguanosine

GN3227-50MG 50 mg
EUR 190

N1-Methyladenosine

GN7727-50MG 50 mg
EUR 269

Pseudouridine

GN9104-50MG 50 mg
EUR 128

Rizatriptan benzoate

GP0042-50MG 50 mg
EUR 150

Suramin sodium salt

GP0138-50MG 50 mg
EUR 110

Rofecoxib

GP0159-50MG 50 mg
EUR 86

Epigallocatechin gallate

GP0260-50MG 50 mg
EUR 72

Betaxolol hydrochloride

GP0555-50MG 50 mg
EUR 110

Tonabersat

GP0580-50MG 50 mg
EUR 628

Salmeterol xinafoate

GP0706-50MG 50 mg
EUR 94

Boceprevir

GP0844-50MG 50 mg
EUR 778

Perindopril erbumine

GP1522-50MG 50 mg
EUR 92

Valaciclovir hydrochloride

GP1612-50MG 50 mg
EUR 46

Forskolin

GP2059-50MG 50 mg
EUR 309

Gatifloxacin hydrate

GP2111-50MG 50 mg
EUR 90

Sunitinib malate

GP2160-50MG 50 mg
EUR 102

Methysergide maleate salt

GP2886-50MG 50 mg
EUR 668

Bosentan hydrate

GP5893-50MG 50 mg
EUR 130

Carmofure

GP5925-50MG 50 mg
EUR 154

Zafirlukast

GP6218-50MG 50 mg
EUR 110

Tolazamide

GP6227-50MG 50 mg
EUR 237

Lopinavir

GP6351-50MG 50 mg
EUR 70

Acadesine

GP6637-50MG 50 mg
EUR 154

Indinavir sulphate hydrate

GP6821-50MG 50 mg
EUR 126

Acepromazine maleate

GP6873-50MG 50 mg
EUR 110

Curcumin, pure, 98%

GP7022-50MG 50 mg
EUR 160

Saquinavir mesylate

GP7183-50MG 50 mg
EUR 150

Levosimendan

GP7196-50MG 50 mg
EUR 110

Nelfinavir mesylate

GP7332-50MG 50 mg
EUR 349

Celastrol

GP7348-50MG 50 mg
EUR 620

Apixaban

GP7497-50MG 50 mg
EUR 126

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.