cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

(S)-MCPG

B6266-5 5 mg
EUR 139.2

(RS)-MCPG

HY-100371 100mg
EUR 1135.2

(S)-MCPG

HY-100406 5mg
EUR 159.6

(S)-MCPG

B6266-50 50mg
EUR 654
Description: mGluR antagonist

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 362.4

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 1336.8

(RS)-MCPG disodium salt

B7476-100 100mg
EUR 1125
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-25 25mg
EUR 348
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-5 5mg
EUR 114
Description: group I/group II metabotropic glutamate receptor antagonist

L-NMMA: (50mg)

00224 25MG
EUR 248.4
Description: Minimum order quantity: 1 unit of 25MG

Mitomycin C, 50mg

R5007-50mg each
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Mitomycin C, 50mg

R5007 50mg
EUR 1190.08

Gentamicin, 50mg/ml

CA003-001 10ml
EUR 109.2

Biotin-12, SE: (50mg)

90083 50MG
EUR 231.6
Description: Minimum order quantity: 1 unit of 50MG

50mg Blasticidin S HCl

30-100-RB EACH
EUR 231.6

Timentin Solution, 50mg/mL

40110059-1 20 mL
EUR 23.8

Timentin Solution, 50mg/mL

40110059-2 50 mL
EUR 33.86

Timentin Solution, 50mg/mL

40110059-3 100 mL
EUR 44.84

Kanamycin solution (50mg/ml)

MN800A-1 20 ml
EUR 75

DiD (or DiIC18(5)): (50mg)

60014 50MG
EUR 193.2
Description: Minimum order quantity: 1 unit of 50MG

Cy3 Bis Nhs Ester 50Mg

PA13002 EACH
EUR 8811.6

50mg/mL G-418 Solution

PB180125-10mL 10 mL
EUR 55
Description: Supplements & Reagents

Wire Weight 50mg E2 Dakks

YCW152102 EACH
EUR 150

G418 Sulfate, 50mg/mL, Sterile

40710027-1 20 mL
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50mg/mL Hygromycin B Solution

PB180126-10mL 10 mL
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Description: Supplements & Reagents

Erythromycin Solution, 50mg/mL, Sterile

40120785-1 25 mL
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Erythromycin Solution, 50mg/mL, Sterile

40120785-2 50 mL
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Erythromycin Solution, 50mg/mL, Sterile

40120785-3 100 mL
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Chloramphenicol Solution, 50mg/mL, Sterile

40110067-1 10 mL
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Chloramphenicol Solution, 50mg/mL, Sterile

40110067-2 25 mL
EUR 45.48

C18(EC) 50mg/1mL SPE Columns

CHR5622 PK100
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Goat Anti-Mouse IgG Fc, 50MG

A008-50MG 50MG
EUR 938

Goat Anti-Rabbit IgG Fc, 50MG

A009-50MG 50MG
EUR 938

C18(EC) 50mg Fixed-well Plate

CHR5624 EACH
EUR 298.8

Standard Nitrile 50mg/L as N

SDN0501 1L
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Amersham Cy5 Bis NHS ester 50mg

PA15002 EACH
EUR 6852

Amersham Cy5 mono NHS ester 50mg

PA15102 EACH
EUR 8367.6

Amersham Cy55 Bis NHS ester 50mg

PA15502 EACH
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Caffeine Standard 50mg/L in Water

CAFSTD50005 5ML
EUR 438

Hygromycin B Solution, 50mg/mL, Sterile

40810004-1 25 mL
EUR 80.99

Hygromycin B Solution, 50mg/mL, Sterile

40810004-2 50 mL
EUR 150.08

Neomycin Sulfate Solution, 50mg/mL, Sterile

40110068-1 10 mL
EUR 31.67

Neomycin Sulfate Solution, 50mg/mL, Sterile

40110068-2 25 mL
EUR 45.48

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-1 25 mL
EUR 31.57

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-2 50 mL
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Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-3 100 mL
EUR 73.01

Gentamicin Sulfate Solution, 50mg/mL, Sterile

40710024-1 20 mL
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Gentamicin Sulfate Solution, 50mg/mL, Sterile

40710024-2 100 mL
EUR 112.16

Recombinant Bovine ATF Protein, Untagged, -50mg

QP11095-50mg 50mg
EUR 186

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-1 10 mL
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Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-2 25 mL
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Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-3 50 mL
EUR 35.69

X-Gal Solution, 50mg/mL in DMF

21530036-1 2 mL
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X-Gal Solution, 50mg/mL in DMF

21530036-2 5 mL
EUR 85.98

Peracetic Acid Indicator Strips 0-50mg/L

PAP1234 PK100
EUR 24

Donkey Anti-Sheep IgG (H&L), 50MG

A010-50MG 50MG
EUR 938

Alkalinity Std 50mg/L 50ppm as CaCO3

TA0501 1L
EUR 393.6

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-1 10 mL
EUR 26.54

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-2 25 mL
EUR 53.99

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-3 50 mL
EUR 89.68

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-1 25 mL
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Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-2 50 mL
EUR 57.89

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-3 100 mL
EUR 76.66

Kinesis TELOS QuEChERS Clean-up Kit Dispersive Pigmented Fruit and Veg; AOAC 2007.01; 150mg MgSO4 50mg PSA 50mg PestiCarb; 2ml

CHR6487 PK100
EUR 253.2

IC Anion Std Nitrate 50mg/L in H2O

ICAA04 500ML
EUR 117.5

IC Cation Std Ammonium 50mg/L in H2O

ICCA01 500ML
EUR 117.5

Recombinant Multi Species ACTH Protein, Untagged, -50mg

QP10950-50mg 50mg
EUR 663.6

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-1 10 mL
EUR 17.39

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-2 25 mL
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Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-3 100 mL
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Spectropho Pot Dichro A/T Std 50mg/L

RSPEC00201 100ML
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Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile Tubes

40121048-1 25 tube(s) Ask for price

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile Tubes

40121048-2 50 tube(s) Ask for price

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

40120724-1 25 tube(s) Ask for price

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

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Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

40120724-3 100 tube(s) Ask for price

BioMag® Dextran-coated Charcoal Concentrate (50mg/ml)

84555-1 1l
EUR 1759

Spectropho Pot Dichro A/T Std 50mg/L in Cuvs

RSPEC0020 PK2
EUR 1396.8

ICP Multi Elem (12) Tuning Std in 2% HNO3 50mg/L each

ICP12-50-100 100ML
EUR 489.6

Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; AOAC 2007.01; 150mg MgSO4 and 50mg PSA;2ml

CHR6478 PK100
EUR 152.4

Recombinant other Terlipressin Protein, Untagged, E.coli-50mg

QP13723-50mg 50mg
EUR 435.6

Recombinant Bovine HTF Protein, Untagged, E.coli-50mg

QP12351-50mg 50mg
EUR 186

Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg

QP12522-50mg 50mg
EUR 4386

Recombinant other Urease Protein, Untagged, E.coli-50mg

QP10907-50mg 50mg
EUR 1251.6

Recombinant other Atosiban Protein, Untagged, E.coli-50mg

QP11102-50mg 50mg
EUR 261.6

Recombinant other Exenatide Protein, Untagged, E.coli-50mg

QP11816-50mg 50mg
EUR 2829.6

Recombinant Human CTRB1 Protein, Untagged, E.coli-50mg

QP10565-50mg 50mg
EUR 675.6

Recombinant Yeast IDH1 Protein, Untagged, Yeast-50mg

QP10670-50mg 50mg
EUR 1251.6

Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg

QP12314-50mg 50mg
EUR 241.2

Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg

QP12317-50mg 50mg
EUR 435.6

Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg

QP10897-50mg 50mg
EUR 1154.4

Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg

QP10899-50mg 50mg
EUR 675.6

Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg

QP10544-50mg 50mg
EUR 620.4

Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg

QP12316-50mg 50mg
EUR 435.6

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg

QP11479-50mg 50mg
EUR 1111.2

Alkalinity Std 10000mg/L 10000ppm as CaCO3

TA10M5 500ML
EUR 374.4

Alkalinity Std 4000mg/L 4000ppm as CaCO3

TA4M05 500ML
EUR 360

semi balance 60/120mg 0.01/0.1mg

BAL1164 EACH
EUR 8348.4

Pot Dichro A/T Std 80mg/L w/ 0.005M Sulph Acid in Cuv

RSPEC-EP00880 EACH
EUR 1357.82

Pot Dichro A/T Std 600mg/L w/ 0.005M Sulph Acid 2x Blanks in Cuvs

RSPEC-EP0061X2BU PK3
EUR 1415.27

Pot Dichro A/T Std 100mg/L w/ 0.005M Sulph Acid 2x Blanks in Cuvs

RSPEC-EP0100X2BU PK3
EUR 1415.27

Alkalinity Std 100mg/L 100ppm as CaCO3

TA1001 1L
EUR 392.4

Alkalinity Std 250mg/L 250ppm as CaCO3

TA2501 1L
EUR 234

CD163 (Monocyte & Macrophage Marker)(M130/2162), 0.2mg/mL

BNUB2162-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD163 (Monocyte & Macrophage Marker)(M130/2162), 0.2mg/mL

BNUB2162-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD163 (Monocyte & Macrophage Marker)(M130/2164), 0.2mg/mL

BNUB2164-100 1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD163 (Monocyte & Macrophage Marker)(M130/2164), 0.2mg/mL

BNUB2164-500 1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD163 (Monocyte & Macrophage Marker)(M130/1210), 1mg/mL

BNUM1210-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD163 (Monocyte & Macrophage Marker)(M130/2162), 1mg/mL

BNUM2162-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD163 (Monocyte & Macrophage Marker)(M130/2164), 1mg/mL

BNUM2164-50 1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

Absorb Std Pot Dichro 60mg/L w/ 0.005M Sulph Acid in Cuvs

RSPEC-CP060 PK2
EUR 1390.46

Pot Dichro A/T Std 60mg/L w/ 0.005M Sulph Acid 2x Blanks in Cuvs

RSPEC-EP0060X2BU PK3
EUR 1415.27

TDS Std 1000mg/L

TDS1000 1L
EUR 67.2

TDS Std 1500mg/L

TDS1500 1L
EUR 67.2

TDS Std 2000mg/L

TDS2000 1L
EUR 67.2

EDC: (100mg)

59002 100MG
EUR 151.2
Description: Minimum order quantity: 1 unit of 100MG

C18 500mg/10mL

CHR5610 PK20
EUR 69.6

SCAS: (100mg)

70037 100MG
EUR 213.6
Description: Minimum order quantity: 1 unit of 100MG

TPEN: (100mg)

59003 100MG
EUR 193.2
Description: Minimum order quantity: 1 unit of 100MG

TDS Std 100mg/L

TDS100 1L
EUR 93.6

TDS Std 250mg/L

TDS250 1L
EUR 156

TDS Std 500mg/L

TDS500 1L
EUR 156

COD test 150-1000mg per L

LCK114 PK25
EUR 142.46

COD Test 15-150mg per L

WAT3624 1KIT
EUR 142.46

COD Test 50-300mg per L

WAT3626 1KIT
EUR 142.46

COD Test 100-2000mg per L

WAT3628 EACH
EUR 142.46

COD Test Kit 25 to 1500mg/L

WAT4314 PK25
EUR 141

COD Test Kit 500 to 10000mg/L

WAT4316 PK25
EUR 141

DiOC6(3): (100mg)

70009 100MG
EUR 247.2
Description: Minimum order quantity: 1 unit of 100MG

MTSES: (100mg)

91020 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSET: (100mg)

91021 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSEA: (100mg)

91022 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSEH: (100mg)

91023 100MG
EUR 310.8
Description: Minimum order quantity: 1 unit of 100MG

MTSPA: (100mg)

91024 100MG
EUR 183.6
Description: Minimum order quantity: 1 unit of 100MG

MTSPS: (100mg)

91025 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSBS: (100mg)

91026 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSPT: (100mg)

91027 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

Rnase A, 250mg

R9001-250mg each
EUR 337.2

Water-soluble Cumate solution (300mg/ml, 10,000x), 500ul

QM150A-1 500 ul
EUR 111

AEAETS:100mg

91031 100MG
EUR 204
Description: Minimum order quantity: 1 unit of 100MG

COD Test Kit 10 to 150mg/L

WAT4312 PK25
EUR 141

AAS Zinc Std 5000mg/L in 2-5% HNO3

AAZN505 500ML
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COD MR 0 to 1500mg/L reagent

WAT1032 EACH
EUR 84

COD HR 0 to 15000mg/L reagent

WAT1034 EACH
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Nitrate Std 1000mg/L as N

SDN01000 500ML
EUR 404.4

Nitrate Std 1000mg/L as N

SDN010001 1L
EUR 182.4

Low range cod vial 3-150mg

21258-51 PK25
EUR 116.4

Chloride Std 2200mg/L

CL22001 1L
EUR 280.8

Chloride Std 10000mg/L as Cl

CLHY10M5 500ML
EUR 175.2

COD Vials 13 mm Hg free 0-1000mg per l

LCK214 PK25
EUR 150

ICP Multi Elem (9) Std 1000mg/L

ICPMIX-9-100 100ML
EUR 279.4

BD ecgs bovine 100mg

356006 EACH
EUR 528

Biotin-XX, SE: (100mg)

90052 100MG
EUR 290.4
Description: Minimum order quantity: 1 unit of 100MG

C8(EC) 100mg/1mL SPE Colum

CHR5654 PK100
EUR 213.6

COD LR 0 to 150mg/L reagent

WAT1030 EACH
EUR 84

Nitrate Std 100mg/L as N

SDN01001 1L
EUR 212.81

Nitrate Std 500mg/L as N

SDN05005 500ML
EUR 351.6

Nitrate Std 200mg/L as N

SDNO2001 1L
EUR 330

LYSOZYME - 110mg

IB47633 W/BACTERIA LYSIS BUFFER - 15ML
EUR 92.7

LYSOZYME - 250mg [FR] [*]

IB47634 W/BACTERIA LYSIS BUFFER - 30ML
EUR 159.65

ß2-MG

E62C01601 100ug
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High Range Cod Vial 20-1500mg

21259-51 PK25
EUR 116.4

Zinc Sulphate 1000mg/L

ZN10001 1L
EUR 229.79

Chloride Std 200mgL 100ml

CHL2030 EACH
EUR 19.2

M Butyricum 100Mg

264010 PK6
EUR 261.12

Chloride Std 220mg/L

CL2201 1L
EUR 270

COD STandard 800mg/l

PL474 EACH
EUR 25.2

Rapamycin, 100mg

R5312-100mg each
EUR 902.4

Rapamycin, 100mg

R5312 100mg
EUR 607.18

IC Anion Std Silica 2000mg/L in H2O

ICAC12 500ML
EUR 312

ICP Multi Elem (11) Std in 3.5% HNO3 + 0.5% HF 1000mg/L

ICP-MIX-CYM12 250ML
EUR 817.31

ICP Multi Elem (10) Std in 2% HNO3 1000mg/L

ICP10-1000-100 100ML
EUR 547.05

Ammonium Test 0.015-2mg per L NH

WAT3602 1KIT
EUR 181.44

Ammonium Test 47-130mg per L NH

WAT3608 1KIT
EUR 181.44

Sulphate Test 40-150mg per L

WAT3642 EACH
EUR 170.4

Organic Acid Test 50 to 3000mg/L

WAT4326 PK25
EUR 283.32

ICP Multi Elem (11) Std in 5% HNO3 1000mg/L

REICP11MIX4A 100ML
EUR 439.99

ICP Multi Elem (11) Std in 2% HNO3 1000mg/L

REICPCAL11U 500ML
EUR 876.06

ICP Multi Elem (6) Std USP 232/233 10mg/L in 15% HCL

REICPUSPIV 100ML
EUR 583.6

BSA, 20mg/mL

40220056-1 5 mL
EUR 40.35
Description: Bovine Serum Albumin

BSA, 20mg/mL

40220056-2 5 mL
EUR 40.35
Description: Bovine Serum Albumin

BSA, 20mg/mL

40220056-3 10 mL
EUR 65.06
Description: Bovine Serum Albumin

Ammonium Standard 1mg/L 500mL

189149 EACH
EUR 58.8

TOC/TIC Mixed Std 30mg/L Org 8mg/L Inorg Carb

TOIC308 500ML
EUR 294

NH2 100mg/1mL SPE Columns

CHR5528 PK100
EUR 393.6

NH2 200mg/3mL SPE Columns

CHR5530 PK50
EUR 181.2

NH2 500mg/3mL SPE Columns

CHR5532 PK50
EUR 223.2

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.