cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.
Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.
In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.
Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.
Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg |
|||
QP12522-50mg | EnQuireBio | 50mg | EUR 4386 |
Recombinant other Terlipressin Protein, Untagged, E.coli-50mg |
|||
QP13723-50mg | EnQuireBio | 50mg | EUR 435.6 |
Recombinant other Exenatide Protein, Untagged, E.coli-50mg |
|||
QP11816-50mg | EnQuireBio | 50mg | EUR 2829.6 |
Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg |
|||
QP10544-50mg | EnQuireBio | 50mg | EUR 620.4 |
Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg |
|||
QP10897-50mg | EnQuireBio | 50mg | EUR 1154.4 |
Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg |
|||
QP10899-50mg | EnQuireBio | 50mg | EUR 675.6 |
Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg |
|||
QP12314-50mg | EnQuireBio | 50mg | EUR 241.2 |
Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg |
|||
QP12317-50mg | EnQuireBio | 50mg | EUR 435.6 |
Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg |
|||
QP11479-50mg | EnQuireBio | 50mg | EUR 1111.2 |
Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg |
|||
QP12316-50mg | EnQuireBio | 50mg | EUR 435.6 |
(RS)-MCPG |
|||
B6265-10 | ApexBio | 10 mg | EUR 297.6 |
(RS)-MCPG |
|||
B6265-100 | ApexBio | 100 mg | EUR 1796.4 |
(RS)-MCPG |
|||
B6265-25 | ApexBio | 25 mg | EUR 602.4 |
(RS)-MCPG |
|||
B6265-5 | ApexBio | 5 mg | EUR 234 |
(RS)-MCPG |
|||
B6265-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 250.8 |
(RS)-MCPG |
|||
B6265-50 | ApexBio | 50 mg | EUR 1015.2 |
(S)-MCPG |
|||
B6266-10 | ApexBio | 10 mg | EUR 211.2 |
(S)-MCPG |
|||
B6266-25 | ApexBio | 25 mg | EUR 420 |
(S)-MCPG |
|||
B6266-5 | ApexBio | 5 mg | EUR 139.2 |
(RS)-MCPG |
|||
HY-100371 | MedChemExpress | 100mg | EUR 1135.2 |
(S)-MCPG |
|||
HY-100406 | MedChemExpress | 5mg | EUR 159.6 |
DiA: (50mg) |
|||
60013 | Biotium | 50MG | EUR 252 |
Description: Minimum order quantity: 1 unit of 50MG |
(RS)-MCPG disodium salt |
|||
B7476-10 | ApexBio | 10 mg | EUR 362.4 |
(RS)-MCPG disodium salt |
|||
B7476-50 | ApexBio | 50 mg | EUR 1336.8 |
Gentamicin, 50mg/ml |
|||
CA003-001 | GenDepot | 10ml | EUR 109.2 |
L-NMMA: (50mg) |
|||
00224 | Biotium | 25MG | EUR 248.4 |
Description: Minimum order quantity: 1 unit of 25MG |
Biotin-12, SE: (50mg) |
|||
90083 | Biotium | 50MG | EUR 231.6 |
Description: Minimum order quantity: 1 unit of 50MG |
Kanamycin solution (50mg/ml) |
|||
MN800A-1 | SBI | 20 ml | EUR 152.4 |
50mg Blasticidin S HCl |
|||
30-100-RB | Scientific Laboratory Supplies | EACH | EUR 220.02 |
DiD (or DiIC18(5)): (50mg) |
|||
60014 | Biotium | 50MG | EUR 193.2 |
Description: Minimum order quantity: 1 unit of 50MG |
Cy3 Bis Nhs Ester 50Mg |
|||
PA13002 | Scientific Laboratory Supplies | EACH | EUR 7407.72 |
Wire Weight 50mg E2 Dakks |
|||
YCW152102 | Scientific Laboratory Supplies | EACH | EUR 127.68 |
Amersham Cy5 Bis NHS ester 50mg |
|||
PA15002 | Scientific Laboratory Supplies | EACH | EUR 5760.42 |
Amersham Cy5 mono NHS ester 50mg |
|||
PA15102 | Scientific Laboratory Supplies | EACH | EUR 7033.8 |
Amersham Cy55 Bis NHS ester 50mg |
|||
PA15502 | Scientific Laboratory Supplies | EACH | EUR 7082.82 |
Standard Nitrile 50mg/L as N |
|||
SDN0501 | Scientific Laboratory Supplies | 1L | EUR 315.78 |
C18(EC) 50mg/1mL SPE Columns |
|||
CHR5622 | Scientific Laboratory Supplies | PK100 | EUR 156.18 |
Caffeine Standard 50mg/L in Water |
|||
CAFSTD50005 | Scientific Laboratory Supplies | 5ML | EUR 356.82 |
C18(EC) 50mg Fixed-well Plate |
|||
CHR5624 | Scientific Laboratory Supplies | EACH | EUR 221.16 |
Peracetic Acid Indicator Strips 0-50mg/L |
|||
PAP1234 | Scientific Laboratory Supplies | PK100 | EUR 19.17 |
Alkalinity Std 50mg/L 50ppm as CaCO3 |
|||
TA0501 | Scientific Laboratory Supplies | 1L | EUR 320.34 |
IC Anion Std Nitrate 50mg/L in H2O |
|||
ICAA04 | Scientific Laboratory Supplies | 500ML | EUR 93.48 |
IC Cation Std Ammonium 50mg/L in H2O |
|||
ICCA01 | Scientific Laboratory Supplies | 500ML | EUR 93.48 |
Spectropho Pot Dichro A/T Std 50mg/L |
|||
RSPEC00201 | Scientific Laboratory Supplies | 100ML | EUR 205.2 |
Kinesis TELOS QuEChERS Clean-up Kit Dispersive Pigmented Fruit and Veg; AOAC 2007.01; 150mg MgSO4 50mg PSA 50mg PestiCarb; 2ml |
|||
CHR6487 | Scientific Laboratory Supplies | PK100 | EUR 189.24 |
Bml 277 |
|||
20-abx076616 | Abbexa |
|
|
SMER3 |
|||
20-abx076619 | Abbexa |
|
|
Actinomycin D |
|||
20-abx076620 | Abbexa |
|
|
Mitomycin C |
|||
20-abx076621 | Abbexa |
|
|
LDN-57444 |
|||
20-abx076622 | Abbexa |
|
|
Doxorubicin Hydrochloride |
|||
20-abx076623 | Abbexa |
|
|
Fasudil |
|||
20-abx076624 | Abbexa |
|
|
Pyr3 |
|||
20-abx076630 | Abbexa |
|
|
SB-366791 |
|||
20-abx076632 | Abbexa |
|
|
Forskolin |
|||
20-abx076633 | Abbexa |
|
|
E-4031 |
|||
20-abx076635 | Abbexa |
|
|
Nigericin |
|||
20-abx076636 | Abbexa |
|
|
KB-R7943 mesylate |
|||
20-abx076637 | Abbexa |
|
|
P32 / 98 |
|||
20-abx076640 | Abbexa |
|
|
R(-)-Gossypol |
|||
20-abx076641 | Abbexa |
|
|
Celastrol |
|||
20-abx076642 | Abbexa |
|
|
NSC-66811 |
|||
20-abx076643 | Abbexa |
|
|
JX 401 |
|||
20-abx076645 | Abbexa |
|
|
GW 441756 |
|||
20-abx076646 | Abbexa |
|
|
Kainic acid |
|||
20-abx076647 | Abbexa |
|
|
Deguelin |
|||
20-abx076648 | Abbexa |
|
|
BC-11-38 |
|||
20-abx076649 | Abbexa |
|
|
PJ-34 |
|||
20-abx076650 | Abbexa |
|
|
Quisqualic Acid |
|||
20-abx076651 | Abbexa |
|
|
Xanthohumol |
|||
20-abx076653 | Abbexa |
|
|
Retinoic acid |
|||
20-abx076656 | Abbexa |
|
|
2-APB |
|||
20-abx076657 | Abbexa |
|
|
5-Azacytidine |
|||
20-abx076660 | Abbexa |
|
|
Puromycin HCl |
|||
20-abx076662 | Abbexa |
|
|
Clozapine |
|||
20-abx076666 | Abbexa |
|
|
Itraconazole |
|||
20-abx076667 | Abbexa |
|
|
Nicardipine HCl |
|||
20-abx076668 | Abbexa |
|
|
Hinokitiol |
|||
20-abx076673 | Abbexa |
|
|
SAHA (Vorinostat) |
|||
20-abx076681 | Abbexa |
|
|
CAPE |
|||
20-abx076682 | Abbexa |
|
|
Amlodipine |
|||
20-abx076693 | Abbexa |
|
|
Ambroxol HCl |
|||
20-abx076696 | Abbexa |
|
|
Gefitinib |
|||
20-abx076698 | Abbexa |
|
|
Ro 20-1724 |
|||
20-abx076704 | Abbexa |
|
|
Edaravone |
|||
20-abx076734 | Abbexa |
|
|
Nitrendipine |
|||
20-abx076743 | Abbexa |
|
|
WY-14643 |
|||
20-abx076749 | Abbexa |
|
|
Irinotecan HCl |
|||
20-abx076771 | Abbexa |
|
|
Simvastatin |
|||
20-abx076772 | Abbexa |
|
|
Montelukast sodium |
|||
20-abx076787 | Abbexa |
|
|
Pinacidil Monohydrate |
|||
20-abx076841 | Abbexa |
|
|
Mycophenolate mofetil |
|||
20-abx076846 | Abbexa |
|
|
Genistein |
|||
20-abx076504 | Abbexa |
|
|
Difluoromethylornithine |
|||
20-abx076505 | Abbexa |
|
|
AICAR |
|||
20-abx076506 | Abbexa |
|
|
Ebselen |
|||
20-abx076507 | Abbexa |
|
|
Apigenin |
|||
20-abx076511 | Abbexa |
|
|
Valinomycin |
|||
20-abx076516 | Abbexa |
|
|
HPA |
|||
20-abx076517 | Abbexa |
|
|
Anisomycin |
|||
20-abx076518 | Abbexa |
|
|
Pifithrin mu |
|||
20-abx076519 | Abbexa |
|
|
Carnosic acid |
|||
20-abx076520 | Abbexa |
|
|
Lovastatin |
|||
20-abx076523 | Abbexa |
|
|
Miglitol |
|||
20-abx076525 | Abbexa |
|
|
Necrostatin |
|||
20-abx076526 | Abbexa |
|
|
Zerumbone |
|||
20-abx076528 | Abbexa |
|
|
Rosiglitazone Maleate |
|||
20-abx076529 | Abbexa |
|
|
Tranilast |
|||
20-abx076530 | Abbexa |
|
|
Teprenone |
|||
20-abx076531 | Abbexa |
|
|
Duloxetine HCl |
|||
20-abx076532 | Abbexa |
|
|
Sorafenib |
|||
20-abx076534 | Abbexa |
|
|
Vandetanib |
|||
20-abx076535 | Abbexa |
|
|
Betulinic Acid |
|||
20-abx076536 | Abbexa |
|
|
Felodipine |
|||
20-abx076537 | Abbexa |
|
|
FK506 |
|||
20-abx076538 | Abbexa |
|
|
TOFA |
|||
20-abx076541 | Abbexa |
|
|
Lenalidomide |
|||
20-abx076543 | Abbexa |
|
|
Vatalanib Dihydrochloride |
|||
20-abx076544 | Abbexa |
|
|
Dimethyloxaloylglycine (DMOG) |
|||
20-abx076547 | Abbexa |
|
|
Astemizole |
|||
20-abx076549 | Abbexa |
|
|
Decitabine |
|||
20-abx076551 | Abbexa |
|
|
Tolcapone |
|||
20-abx076552 | Abbexa |
|
|
Amifostine |
|||
20-abx076553 | Abbexa |
|
|
Lapatinib |
|||
20-abx076556 | Abbexa |
|
|
D-LAP5 |
|||
20-abx076557 | Abbexa |
|
|
D-LAP5.Na |
|||
20-abx076558 | Abbexa |
|
|
C2 Ceramide |
|||
20-abx076559 | Abbexa |
|
|
(R, S)-Niguldipine HCl |
|||
20-abx076561 | Abbexa |
|
|
BCTC |
|||
20-abx076566 | Abbexa |
|
|
Isradipine |
|||
20-abx076567 | Abbexa |
|
|
BRL-50481 |
|||
20-abx076568 | Abbexa |
|
|
SP600125 |
|||
20-abx076569 | Abbexa |
|
|
Rottlerin |
|||
20-abx076570 | Abbexa |
|
|
FCCP |
|||
20-abx076572 | Abbexa |
|
|
WHI P131 |
|||
20-abx076573 | Abbexa |
|
|
HC-030031 |
|||
20-abx076575 | Abbexa |
|
|
A-803467 |
|||
20-abx076576 | Abbexa |
|
|
Rolipram |
|||
20-abx076577 | Abbexa |
|
|
Hydroxychloroquine |
|||
20-abx076578 | Abbexa |
|
|
AS 041164 |
|||
20-abx076579 | Abbexa |
|
|
SC 514 |
|||
20-abx076580 | Abbexa |
|
|
BSI 201 |
|||
20-abx076581 | Abbexa |
|
|
AG 494 |
|||
20-abx076583 | Abbexa |
|
|
IU1 |
|||
20-abx076584 | Abbexa |
|
|
Veratridine |
|||
20-abx076585 | Abbexa |
|
|
Nocodazole |
|||
20-abx076586 | Abbexa |
|
|
STF-62247 |
|||
20-abx076587 | Abbexa |
|
|
BAY 11 7082 |
|||
20-abx076588 | Abbexa |
|
|
ML297 |
|||
20-abx076589 | Abbexa |
|
|
Sulindac Sulfide |
|||
20-abx076592 | Abbexa |
|
|
Sulindac Sulfone |
|||
20-abx076593 | Abbexa |
|
|
Antibiotic A-23187 |
|||
20-abx076596 | Abbexa |
|
|
Z-Asp-CH2-DCB |
|||
20-abx076598 | Abbexa |
|
|
Taxol |
|||
20-abx076600 | Abbexa |
|
|
AP-18 |
|||
20-abx076607 | Abbexa |
|
|
TCID |
|||
20-abx076608 | Abbexa |
|
|
1-Deoxynojirimycin |
|||
20-abx076609 | Abbexa |
|
|
Docetaxel |
|||
20-abx076610 | Abbexa |
|
|
A-967079 |
|||
20-abx076611 | Abbexa |
|
|
Flupirtine maleate |
|||
20-abx076612 | Abbexa |
|
|
Troglitazone |
|||
20-abx076613 | Abbexa |
|
|
Dofetilide |
|||
20-abx076614 | Abbexa |
|
|
Bromfenac sodium |
|||
20-abx182389 | Abbexa |
|
|
Cabozantinib, XL184 |
|||
20-abx182391 | Abbexa |
|
|
D-23129,Ezogabine,N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamicacidethylester |
|||
20-abx182411 | Abbexa |
|
|
Dabrafenib |
|||
20-abx182412 | Abbexa |
|
|
Diazoxide |
|||
20-abx182416 | Abbexa |
|
|
Ingenol |
|||
20-abx182495 | Abbexa |
|
|
Ly2157299 |
|||
20-abx182508 | Abbexa |
|
|
Ly2835219 |
|||
20-abx182509 | Abbexa |
|
|
Prucalopride |
|||
20-abx182627 | Abbexa |
|
|
Terlipressin Peptide |
|||
20-abx260093 | Abbexa |
|
|
Cow Apo Transferrin Protein |
|||
20-abx263098 | Abbexa |
|
|
Atosiban Peptide |
|||
20-abx263519 | Abbexa |
|
|
Co-1686 |
|||
20-abx183952 | Abbexa |
|
|
Enzastaurin |
|||
20-abx184026 | Abbexa |
|
|
Iloperidone |
|||
20-abx184123 | Abbexa |
|
|
Ly411575 |
|||
20-abx184164 | Abbexa |
|
|
Mpep |
|||
20-abx184236 | Abbexa |
|
|
N-[2-[4-(2-Methoxyphenyl)-1-Piperazinyl]Ethyl]-N-2-Pyridinyl-Cyclohexanecarboxamide Maleate |
|||
20-abx184252 | Abbexa |
|
|
Sd-208 |
|||
20-abx184357 | Abbexa |
|
|
Stf-62247 |
|||
20-abx184379 | Abbexa |
|
|
Tideglusib |
|||
20-abx184443 | Abbexa |
|
|
Upf 1069 |
|||
20-abx184469 | Abbexa |
|
|
Vu 0364439 |
|||
20-abx184478 | Abbexa |
|
|
2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide |
|||
20-abx184531 | Abbexa |
|
|
Ibrutinib |
|||
20-abx184706 | Abbexa |
|
|
Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.