cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

(S)-MCPG

B6266-25 25 mg
EUR 304
Description: mGluR antagonist

(S)-MCPG

B6266-5 5 mg
EUR 106
Description: mGluR antagonist

(S)-MCPG

B6266-50 50mg
EUR 523
Description: mGluR antagonist

(S)-MCPG

M199718 1g
EUR 7600
Description: 150145-89-4

(RS)-MCPG

M264743 100mg
EUR 3000
Description: 146669-29-6

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Description: (RS)-MCPG

(RS)-MCPG

HY-100371 100mg
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(S)-MCPG

HY-100406 5mg
EUR 159.6

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Description: (S)-MCPG

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 126
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-100 100mg
EUR 900
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-25 25mg
EUR 278
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-5 5mg
EUR 91
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 490
Description: group I/group II metabotropic glutamate receptor antagonist

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Description: (RS)-MCPG disodium salt

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Description: (RS)-MCPG disodium salt

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Description: (RS)-MCPG disodium salt

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Mitomycin C, 50mg

R5007 50mg
EUR 1190.08

Mitomycin C, 50mg

R5007-50mg each
EUR 1712.4

Gentamicin, 50mg/ml

CA003-001 10ml
EUR 109.2

Timentin Solution, 50mg/mL

40110059-1 20 mL
EUR 23.8

Timentin Solution, 50mg/mL

40110059-2 50 mL
EUR 33.86

Timentin Solution, 50mg/mL

40110059-3 100 mL
EUR 44.84

Kanamycin solution (50mg/ml)

MN800A-1 20 ml
EUR 75

Gentamicin Solution, 50mg/mL

25-533 10 mL/Unit
EUR 19.67
Description: Sterile Solution

50mg/mL G-418 Solution

PB180125-10mL 10 mL
EUR 55
Description: Supplements & Reagents

50mg/mL G-418 Solution

PB180125 10mL
EUR 55
Description: Antibiotics

50mg Blasticidin S HCl - EACH

30-100-RB EACH
EUR 260.55

G418 Sulfate, 50mg/mL, Sterile

40710027-1 20 mL
EUR 85.98

50mg/mL Hygromycin B Solution

PB180126-10mL 10 mL
EUR 88
Description: Supplements & Reagents

50mg/mL Hygromycin B Solution

PB180126 10mL
EUR 88
Description: Antibiotics

Kanamycin Sulfate Solution(50mg/ml)

11981-04 20ML
EUR 42

Deoxyribonuclease I (DNase I), 50mg

PC0704-50mg each Ask for price

Gentamicin Sulfate Solution(50mg/ml)

11980-14 10ML
EUR 56

Erythromycin Solution, 50mg/mL, Sterile

40120785-1 25 mL
EUR 24.71

Erythromycin Solution, 50mg/mL, Sterile

40120785-2 50 mL
EUR 39.35

Erythromycin Solution, 50mg/mL, Sterile

40120785-3 100 mL
EUR 72.29

Chloramphenicol Solution, 50mg/mL, Sterile

40110067-1 10 mL
EUR 31.67

Chloramphenicol Solution, 50mg/mL, Sterile

40110067-2 25 mL
EUR 45.48

Cy3 Bis Nhs Ester 50Mg - EACH

PA13002 EACH
EUR 9913.05

Goat Anti-Mouse IgG Fc, 50MG

A008-50MG 50MG
EUR 1022.42

Goat Anti-Rabbit IgG Fc, 50MG

A009-50MG 50MG
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Wire Weight 50mg E2 Dakks - EACH

YCW152102 EACH
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Hygromycin B Solution, 50mg/mL, Sterile

40810004-1 25 mL
EUR 80.99

Hygromycin B Solution, 50mg/mL, Sterile

40810004-2 50 mL
EUR 150.08

Neomycin Sulfate Solution, 50mg/mL, Sterile

40110068-1 10 mL
EUR 31.67

Neomycin Sulfate Solution, 50mg/mL, Sterile

40110068-2 25 mL
EUR 45.48

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-1 25 mL
EUR 31.57

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-2 50 mL
EUR 52.71

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-3 100 mL
EUR 73.01

Gentamicin Sulfate Solution, 50mg/mL, Sterile

40710024-1 20 mL
EUR 44.92

Gentamicin Sulfate Solution, 50mg/mL, Sterile

40710024-2 100 mL
EUR 112.16

Recombinant Bovine ATF Protein, Untagged, -50mg

QP11095-50mg 50mg
EUR 186

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-1 10 mL
EUR 12.81

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-2 25 mL
EUR 19.22

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-3 50 mL
EUR 35.69

X-Gal Solution, 50mg/mL in DMF

21530036-1 2 mL
EUR 57.59

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21530036-2 5 mL
EUR 85.98

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-1 10 mL
EUR 26.54

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-2 25 mL
EUR 53.99

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-3 50 mL
EUR 89.68

C18(EC) 50mg/1mL SPE Columns - PK100

CHR5622 PK100
EUR 234.9

Standard Nitrile 50mg/L as N - 1L

SDN0501 1L
EUR 443.58

Donkey Anti-Sheep IgG (H&L), 50MG

A010-50MG 50MG
EUR 1022.42

C18(EC) 50mg Fixed-well Plate - EACH

CHR5624 EACH
EUR 336.15

Amersham Cy5 Bis NHS ester 50mg - EACH

PA15002 EACH
EUR 7708.5

Amersham Cy5 mono NHS ester 50mg - EACH

PA15102 EACH
EUR 9413.55

Amersham Cy55 Bis NHS ester 50mg - EACH

PA15502 EACH
EUR 9478.35

Caffeine Standard 50mg/L in Water - 5ML

CAFSTD50005 5ML
EUR 492.75

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-1 25 mL
EUR 35.21

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-2 50 mL
EUR 57.89

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-3 100 mL
EUR 76.66

Spectropho Pot Dichro A/T Std 50mg/L - 100ML

RSPEC00201 100ML
EUR 286.2

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-1 10 mL
EUR 17.39

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-2 25 mL
EUR 26.54

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-3 100 mL
EUR 61.8

Recombinant Multi Species ACTH Protein, Untagged, -50mg

QP10950-50mg 50mg
EUR 663.6

Peracetic Acid Indicator Strips 0-50mg/L - PK100

PAP1234 PK100
EUR 27

Alkalinity Std 50mg/L 50ppm as CaCO3 - 1L

TA0501 1L
EUR 442.8

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile Tubes

40121048-1 25 tube(s) Ask for price

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile Tubes

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Kinesis TELOS QuEChERS Clean-up Kit Dispersive Pigmented Fruit and Veg; AOAC 2007.01; 150mg MgSO4 50mg PSA 50mg PestiCarb; 2ml - PK100

CHR6487 PK100
EUR 284.85

IC Anion Std Nitrate 50mg/L in H2O - 500ML

ICAA04 500ML
EUR 132.19

IC Cation Std Ammonium 50mg/L in H2O - 500ML

ICCA01 500ML
EUR 132.19

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

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Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

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BioMag® Dextran-coated Charcoal Concentrate (50mg/ml)

84555-1 1l
EUR 1759

OOAU00078-50MG - HPA

OOAU00078-50MG 50mg
EUR 299

OOAU00085-50MG - Decitabine

OOAU00085-50MG 50mg
EUR 539

OOAU00091-50MG - Xanthohumol

OOAU00091-50MG 50mg
EUR 1049

OOMC00003-50MG - Astemizole

OOMC00003-50MG 50mg
EUR 99

OOMC00007-50MG - Rapamycin

OOMC00007-50MG 50mg
EUR 249

OOMC00025-50MG - Entacapone

OOMC00025-50MG 50mg
EUR 159

OOMC00030-50MG - Valinomycin

OOMC00030-50MG 50mg
EUR 189

OOMC00040-50MG - Ebselen

OOMC00040-50MG 50mg
EUR 89

OOMC00042-50MG - Leflunomide

OOMC00042-50MG 50mg
EUR 59

OOMC00043-50MG - Auranofin

OOMC00043-50MG 50mg
EUR 69

OOMC00053-50MG - Omeprazole

OOMC00053-50MG 50mg
EUR 59

OOMC00054-50MG - Emetine

OOMC00054-50MG 50mg
EUR 69

OOMC00060-50MG - Tigecycline

OOMC00060-50MG 50mg
EUR 269

OOMC00074-50MG - Umifenovir

OOMC00074-50MG 50mg
EUR 249

OOMC00076-50MG - Ritonavir

OOMC00076-50MG 50mg
EUR 199

OOMC00080-50MG - Nitazoxanide

OOMC00080-50MG 50mg
EUR 199

OOMC00081-50MG - Trametinib

OOMC00081-50MG 50mg
EUR 199

OOMC00088-50MG - Cepharanthine

OOMC00088-50MG 50mg
EUR 59

Spectropho Pot Dichro A/T Std 50mg/L in Cuvs - PK2

RSPEC0020 PK2
EUR 1571.4

OOAU00074-50MG - SAHA (Vorinostat)

OOAU00074-50MG 50mg
EUR 69

OOAU00082-50MG - 5-Azacytidine

OOAU00082-50MG 50mg
EUR 39

OOAU00090-50MG - BRL-50481

OOAU00090-50MG 50mg
EUR 439

OOAU00093-50MG - H-151

OOAU00093-50MG 50mg
EUR 539

OARA04423-50MG - IgG Antibody

OARA04423-50MG 50mg
EUR 639

OARA04426-50MG - IgG Antibody

OARA04426-50MG 50mg
EUR 639

OARA04427-50MG - IgG Antibody

OARA04427-50MG 50mg
EUR 319

OARA04428-50MG - IgG Antibody

OARA04428-50MG 50mg
EUR 319

OARA04429-50MG - IgG Antibody

OARA04429-50MG 50mg
EUR 639

OARA04431-50MG - IgG Antibody

OARA04431-50MG 50mg
EUR 639

OARA04432-50MG - IgG Antibody

OARA04432-50MG 50mg
EUR 639

OARA04438-50MG - IgM Antibody

OARA04438-50MG 50mg
EUR 709

OARA04441-50MG - IgM Antibody

OARA04441-50MG 50mg
EUR 729

OARA04443-50MG - IgG Antibody

OARA04443-50MG 50mg
EUR 319

OARA04445-50MG - IgG Antibody

OARA04445-50MG 50mg
EUR 319

OARA04449-50MG - IgG Antibody

OARA04449-50MG 50mg
EUR 339

OARA04451-50MG - IgG Antibody

OARA04451-50MG 50mg
EUR 339

OARA04454-50MG - IgG Antibody

OARA04454-50MG 50mg
EUR 529

OARA04458-50MG - IgG Antibody

OARA04458-50MG 50mg
EUR 339

OARA04461-50MG - IgM Antibody

OARA04461-50MG 50mg
EUR 679

OARA04462-50MG - IgG Antibody

OARA04462-50MG 50mg
EUR 439

OARA04463-50MG - IgG Antibody

OARA04463-50MG 50mg
EUR 729

OARA04466-50MG - IgG Antibody

OARA04466-50MG 50mg
EUR 659

OARA04470-50MG - IgM Antibody

OARA04470-50MG 50mg
EUR 729

OARA04474-50MG - IgM Antibody

OARA04474-50MG 50mg
EUR 689

OARA04475-50MG - IgG Antibody

OARA04475-50MG 50mg
EUR 729

OARA04478-50MG - IgG Antibody

OARA04478-50MG 50mg
EUR 659

OARA04479-50MG - IgG Antibody

OARA04479-50MG 50mg
EUR 339

OARA04480-50MG - IgG Antibody

OARA04480-50MG 50mg
EUR 529

OARA04535-50MG - IgG Antibody

OARA04535-50MG 50mg
EUR 639

OARA04552-50MG - IgG Antibody

OARA04552-50MG 50mg
EUR 639

OOMA00041-50MG - Sheep IgG

OOMA00041-50MG 0.05g
EUR 259

OOMC00004-50MG - U-18666A

OOMC00004-50MG 50mg
EUR 379

OOMC00005-50MG - Nafamostat mesylate

OOMC00005-50MG 50mg
EUR 269

OOMC00006-50MG - FK-506

OOMC00006-50MG 50mg
EUR 249

OOMC00010-50MG - Prazosin HCl

OOMC00010-50MG 50mg
EUR 59

OOMC00018-50MG - Hydroxychloroquine sulfate

OOMC00018-50MG 50mg
EUR 49

OOMC00034-50MG - Gemcitabine HCl

OOMC00034-50MG 50mg
EUR 169

OOMC00037-50MG - Camostat mesylate

OOMC00037-50MG 50mg
EUR 169

OOMC00038-50MG - Gabexate mesylate

OOMC00038-50MG 50mg
EUR 169

OOMC00045-50MG - Daunorubicin HCl

OOMC00045-50MG 50mg
EUR 259

OOMC00056-50MG - Nelfinavir mesylate

OOMC00056-50MG 50mg
EUR 229

OOMC00075-50MG - Oseltamivir phosphate

OOMC00075-50MG 50mg
EUR 49

OOMC00079-50MG - RIPA-56  

OOMC00079-50MG 50mg
EUR 189

ICP Multi Elem (12) Tuning Std in 2% HNO3 50mg/L each - 100ML

ICP12-50-100 100ML
EUR 550.8

OOMC00020-50MG - GBR-12909 2HCl

OOMC00020-50MG 50mg
EUR 319

OOMC00033-50MG - Fingolimod (FTY-720)

OOMC00033-50MG 50mg
EUR 69

OPPA01051-50MG - Terlipressin - Terlipressin Protein

OPPA01051-50MG 50mg
EUR 329

OARA04424-50MG - IgG F(c) Antibody

OARA04424-50MG 50mg
EUR 389

OARA04425-50MG - IgG F(c) Antibody

OARA04425-50MG 50mg
EUR 729

OARA04434-50MG - IgG F(c) Antibody

OARA04434-50MG 50mg
EUR 729

OARA04436-50MG - IgG F(c) Antibody

OARA04436-50MG 50mg
EUR 729

OARA04439-50MG - IgG F(c) Antibody

OARA04439-50MG 50mg
EUR 729

OARA04444-50MG - IgG F(c) Antibody

OARA04444-50MG 50mg
EUR 389

OARA04450-50MG - IgM mu chain Antibody

OARA04450-50MG 50mg
EUR 739

OARA04453-50MG - IgM mu chain Antibody

OARA04453-50MG 50mg
EUR 689

OARA04457-50MG - IgM mu chain Antibody

OARA04457-50MG 50mg
EUR 679

OARA04459-50MG - IgG F(c) Antibody

OARA04459-50MG 50mg
EUR 389

OARA04468-50MG - IgM mu chain Antibody

OARA04468-50MG 50mg
EUR 689

OORA00553-50MG - Red Blood Cell Antibody

OORA00553-50MG 50mg
EUR 509

OORA00554-50MG - Red Blood Cell Antibody

OORA00554-50MG 50mg
EUR 509

OORA00555-50MG - Red Blood Cell Antibody

OORA00555-50MG 50mg
EUR 529

OORA00556-50MG - Red Blood Cell Antibody

OORA00556-50MG 50mg
EUR 509

OORA00557-50MG - Red Blood Cell Antibody

OORA00557-50MG 50mg
EUR 509

OORA00558-50MG - Red Blood Cell Antibody

OORA00558-50MG 50mg
EUR 509

OORA00566-50MG - Red Blood Cell Antibody

OORA00566-50MG 50mg
EUR 509

Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; AOAC 2007.01; 150mg MgSO4 and 50mg PSA;2ml - PK100

CHR6478 PK100
EUR 171.45

Recombinant Human CTRB1 Protein, Untagged, E.coli-50mg

QP10565-50mg 50mg
EUR 675.6

Recombinant Yeast IDH1 Protein, Untagged, Yeast-50mg

QP10670-50mg 50mg
EUR 1251.6

Recombinant other Urease Protein, Untagged, E.coli-50mg

QP10907-50mg 50mg
EUR 1251.6

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.