cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

Recombinant other Terlipressin Protein, Untagged, E.coli-50mg

QP13723-50mg 50mg
EUR 363

Recombinant Human CTRB1 Protein, Untagged, E.coli-50mg

QP10565-50mg 50mg
EUR 563

Recombinant Yeast IDH1 Protein, Untagged, Yeast-50mg

QP10670-50mg 50mg
EUR 1043

Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg

QP12314-50mg 50mg
EUR 201

Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg

QP12317-50mg 50mg
EUR 363

Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg

QP10897-50mg 50mg
EUR 962

Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg

QP10899-50mg 50mg
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Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg

QP10544-50mg 50mg
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Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg

QP12316-50mg 50mg
EUR 363

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg

QP11479-50mg 50mg
EUR 926

(RS)-MCPG

HY-100371 100mg
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(S)-MCPG

HY-100406 5mg
EUR 133

(RS)-MCPG

B6265-10 10 mg
EUR 248

(RS)-MCPG

B6265-100 100 mg
EUR 1497

(RS)-MCPG

B6265-25 25 mg
EUR 502

(RS)-MCPG

B6265-5 5 mg
EUR 195

(RS)-MCPG

B6265-5.1 10 mM (in 1mL DMSO)
EUR 209

(RS)-MCPG

B6265-50 50 mg
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(S)-MCPG

B6266-10 10 mg
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(S)-MCPG

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(S)-MCPG

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DiA: (50mg)

60013 50MG
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00224 25MG
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Gentamicin, 50mg/ml

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(RS)-MCPG disodium salt

B7476-10 10 mg
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(RS)-MCPG disodium salt

B7476-50 50 mg
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DiOC14(3), hydroxyethanesulfonate: (50mg)

60012 50MG
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Biotin-12, SE: (50mg)

90083 50MG
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Kanamycin solution (50mg/ml)

MN800A-1 20 ml
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DiD (or DiIC18(5)): (50mg)

60014 50MG
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Actinomycin D

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Camptothecin

1039-50MG
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Sulfo-Cyanine7.5 dicarboxylic acid, 50 mg

1382-50mg 50 mg
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BDP R6G azide, 50 mg

1476-50mg 50 mg
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1497-50mg 50 mg
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4119-50MG
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4216-50MG
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SAHA (Vorinostat )

P004-50MG 50MG
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Description: CAS: 149647-78-9

HPA (Hexyl-4-pentynoic acid )

P008-50MG 50MG
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Description: CAS: 96017-59-3

5-Azacytidine

P012-50MG 50MG
EUR 86
Description: CAS: 320-67-2

Decitabine

P015-50MG 50MG
EUR 539
Description: CAS: 2353-33-5

BRL-50481

P020-50MG 50 mg
EUR 441
Description: CAS: 433695-36-4

Xanthohumol

P021-50MG 50MG
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Description: CAS: 6754-58-1

Aztreonam

A017-50MG 50 mg
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Acyclovir (Acycloguanosine)

A090-50MG 50 mg
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(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid

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dabigatran

abx186421-50mg 50 mg
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Irinotecan

abx188740-50mg 50 mg
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Cefepime

C008-50MG 50 mg
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Cefprozil

C017-50MG 50 mg
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Rabbit Anti-Human IgM (u chain)

C020210-50mg 50mg
EUR 6015

Goat Anti-Human IgM(u chain)

C020213-50mg 50mg
EUR 2635

Goat Anti-Human IgG FC

C020220-50mg 50mg
EUR 6015

Rabbit Anti-Human IgG FC

C020221-50mg 50mg
EUR 6015

Goat Anti-Human IgG Fab

C020233-50mg 50mg
EUR 2635

Goat Anti-Human IgG (γ chain)

C020234-50mg 50mg
EUR 2635

Rabbit Anti-Human IgG (γ chain)

C020235-50mg 50mg
EUR 2635

Goat Anti-Human IgG F(AB)2

C020238-50mg 50mg
EUR 2635

Goat Anti-Tree shrew IgG(H+L)

C020239-50mg 50mg
EUR 2635

Rabbit Anti-Human IgG F(AB)2

C020240-50mg 50mg
EUR 2635

Goat Anti-Human IgA

C020242-50mg 50mg
EUR 2635

Clindamycin Hydrochloride

C035-50MG 50 mg
EUR 127

Clindamycin Phosphate

C036-50MG 50 mg
EUR 119

Camptothecin (Camptotheca acuminata)

C070-50MG 50 mg
EUR 77

Cefotiam Dihydrochloride

C095-50MG 50 mg
EUR 144

Camptothecin (Mappia foetida)

C145-50MG 50 mg
EUR 77

Camptothecin sodium

C146-50MG 50 mg
EUR 80

Cidofovir dihydrate

C202-50MG 50 mg
EUR 219

Bleomycin A5 hydrochloride

B004-50MG 50 mg
EUR 397

Bleomycin sulfate USP

B005-50MG 50 mg
EUR 575

Brefeldin A

B012-50MG 50 mg
EUR 335

Bithionol

B035-50MG 50 mg
EUR 72

Bleomycin

B053-50MG 50 mg
EUR 708

Biapenem

B080-50MG 50mg
EUR 198

(R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane

abx180110-50mg 50 mg
EUR 398

Cafenstrole

abx185370-50mg 50 mg
EUR 606

Chicken IgY Protein

abx060688-50mg 50 mg
EUR 551

SL-01

abx076822-50mg 50 mg
EUR 272

Leflunomide

abx076826-50mg 50 mg
EUR 230

Auranofin

abx076835-50mg 50 mg
EUR 272

Horseradish Peroxidase Antibody

abx022688-50mg 50 mg
EUR 954

Aldolase (Rabbit Muscle) Antibody

abx022821-50mg 50 mg
EUR 1052

Carbonic Anhydrase II (CA2) Antibody

abx022828-50mg 50 mg
EUR 857

Elastase Antibody

abx022830-50mg 50 mg
EUR 857

Glucose Oxidase Antibody

abx022832-50mg 50 mg
EUR 1052

Papain (Carica papaya) Antibody

abx022844-50mg 50 mg
EUR 899

Atovaquone

A099-50MG 50 mg
EUR 239

Telithromycin

T015-50MG 50 mg
EUR 291

Tedizolid

T117-50MG 50mg
EUR 481

Tedizolid Phosphate

T118-50MG 50mg
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Tipiracil Hydrochloride

T121-50MG 50mg
EUR 340

Tolvaptan

T125-50MG 50mg
EUR 429

Tenofovir Alafenamide

T128-50MG 50mg
EUR 144

Phenyl b-D-thioglucopyranoside

GC0722-50MG 50 mg
EUR 70

b-D-Allopyranose

GC0862-50MG 50 mg
EUR 61

5-Bromo-4-chloro-3-indolyl b-D-xylopyranoside

GC1526-50MG 50 mg
EUR 94

Methyl N-acetyl-alpha-D-glucosaminide

GC2856-50MG 50 mg
EUR 142

Maltohexaose

GC2935-50MG 50 mg
EUR 86

5-Bromo-4-chloro-3-indolyl b-D-galactopyranoside

GC3237-50MG 50 mg
EUR 54

XTT sodium salt

GC5281-50MG 50 mg
EUR 142

Quercetin 3-b-D-glucoside

GC9169-50MG 50 mg
EUR 114

Spiperone hydrochloride

GE2928-50MG 50 mg
EUR 154

AEBSF hydrochloride

GE4678-50MG 50 mg
EUR 114

5-Methyl-2'-deoxycytidine

GE5158-50MG 50 mg
EUR 75

Asiaticoside

GC7829-50MG 50 mg
EUR 344

Stevioside

GC8309-50MG 50 mg
EUR 367

Trifluridine

GE1913-50MG 50 mg
EUR 102

Actinomycin D

GA0481-50MG 50 mg
EUR 174

Ascomycin

GA1406-50MG 50 mg
EUR 285

Mupirocin

GA2184-50MG 50 mg
EUR 82

Flumethasone

GA2414-50MG 50 mg
EUR 70

Telithromycin

GA2425-50MG 50 mg
EUR 150

Linezolid

GA2609-50MG 50 mg
EUR 126

Brefeldin A

GA2848-50MG 50 mg
EUR 389

Doxorubicin hydrochloride

GA4969-50MG 50 mg
EUR 126

Torezolid

GA5035-50MG 50 mg
EUR 90

Pimaricin

GA5100-50MG 50 mg
EUR 50

Ribavirin

GA5462-50MG 50 mg
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Phleomycin

GA6020-50MG 50 mg
EUR 269

Biapenem

GA6808-50MG 50 mg
EUR 78

Vinblastine sulfate

GA7194-50MG 50 mg
EUR 389

Rapamycin

GA7417-50MG 50 mg
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Ceftibuten hydrate

GA7818-50MG 50 mg
EUR 120

Mitomycin C

GA9147-50MG 50 mg
EUR 269

Moxifloxacin hydrochloride

GA9781-50MG 50 mg
EUR 54

Ribonuclease A, DNase free

GE9871-50MG 50 mg
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PD 98,059

GK2140-50MG 50 mg
EUR 378

Aminopterin dihydrate

GK2974-50MG 50 mg
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Pravastatin sodium salt

GK3699-50MG 50 mg
EUR 110

alpha-Mangostin

GK4316-50MG 50 mg
EUR 269

3-Morpholinosydnonimine hydrochloride

GK4946-50MG 50 mg
EUR 200

H-8 dihydrochloride

GK6037-50MG 50 mg
EUR 252

Ro 61-8048

GK6422-50MG 50 mg
EUR 548

Cisapride monohydrate

GL0434-50MG 50 mg
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AdipoRon hydrochloride

GL0874-50MG 50 mg
EUR 459

Mephenytoin

GL1129-50MG 50 mg
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1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one

GL1507-50MG 50 mg
EUR 321

MTSSL

GL1695-50MG 50 mg
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Tocainide hydrochloride

GL2205-50MG 50 mg
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Thonzonium bromide

GL2255-50MG 50 mg
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WY-14643

GL2940-50MG 50 mg
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Compound 112254

GL3740-50MG 50 mg
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Cyclic Pifithrin-alpha hydrobromide

GL3913-50MG 50 mg
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Shikonin

GL5964-50MG 50 mg
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TOFA

GL6289-50MG 50 mg
EUR 198

4-Aminophenylphosphate sodium salt

GL6836-50MG 50 mg
EUR 252

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine

GK2289-50MG 50 mg
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SC-560

GK2799-50MG 50 mg
EUR 349

Piperlongumine

GK8547-50MG 50 mg
EUR 223

Bay 11-7082

GK8638-50MG 50 mg
EUR 413

PK 11195

GL4857-50MG 50 mg
EUR 321

MnTBAP chloride

GL5377-50MG 50 mg
EUR 154

AdipoRon

GL6438-50MG 50 mg
EUR 390

Epicoprostanol

GL6737-50MG 50 mg
EUR 137

Zerumbone

GL7258-50MG 50 mg
EUR 298

GYY 4137

GL7524-50MG 50 mg
EUR 321

L-Alanyl-L-1-aminoethylphosphonic acid

GL8388-50MG 50 mg
EUR 158

Corosolic acid

GL8496-50MG 50 mg
EUR 668

MnTMPyP pentachloride

GL8780-50MG 50 mg
EUR 154

Compound 112254 hydrochloride

GL8859-50MG 50 mg
EUR 459

Ketanserin (+)-tartrate salt

GL9943-50MG 50 mg
EUR 172

Bay 60-7550

GN2518-50MG 50 mg
EUR 2582

5-(E)-(2-Bromovinyl)-2'-deoxyuridine

GN2626-50MG 50 mg
EUR 150

3'-O-Methylguanosine

GN3227-50MG 50 mg
EUR 190

N1-Methyladenosine

GN7727-50MG 50 mg
EUR 269

Pseudouridine

GN9104-50MG 50 mg
EUR 128

Rizatriptan benzoate

GP0042-50MG 50 mg
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Suramin sodium salt

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Rofecoxib

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Betaxolol hydrochloride

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Salmeterol xinafoate

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GP0844-50MG 50 mg
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Perindopril erbumine

GP1522-50MG 50 mg
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Valaciclovir hydrochloride

GP1612-50MG 50 mg
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Forskolin

GP2059-50MG 50 mg
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Gatifloxacin hydrate

GP2111-50MG 50 mg
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Sunitinib malate

GP2160-50MG 50 mg
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Methysergide maleate salt

GP2886-50MG 50 mg
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Carmofure

GP5925-50MG 50 mg
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Zafirlukast

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Tolazamide

GP6227-50MG 50 mg
EUR 237

Lopinavir

GP6351-50MG 50 mg
EUR 70

Acadesine

GP6637-50MG 50 mg
EUR 154

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.