cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

(S)-MCPG

B6266-5 5 mg
EUR 106
Description: mGluR antagonist

(S)-MCPG

B6266-50 50mg
EUR 523
Description: mGluR antagonist

(RS)-MCPG

555671 100.0mg
EUR 950

(RS)-MCPG

HY-100371 100mg
EUR 1135.2

(S)-MCPG

HY-100406 5mg
EUR 159.6

(S)-MCPG

M199718 1g
EUR 7600
Description: 150145-89-4

(RS)-MCPG

M264743 100mg
EUR 3000
Description: 146669-29-6

(RS)-MCPG

T3479-10mg 10mg Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-1g 1g Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-1mg 1mg Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-50mg 50mg Ask for price
Description: (RS)-MCPG

(RS)-MCPG

T3479-5mg 5mg Ask for price
Description: (RS)-MCPG

(S)-MCPG

T13452-10mg 10mg Ask for price
Description: (S)-MCPG

(S)-MCPG

T13452-1g 1g Ask for price
Description: (S)-MCPG

(S)-MCPG

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Description: (S)-MCPG

(S)-MCPG

T13452-50mg 50mg Ask for price
Description: (S)-MCPG

(S)-MCPG

T13452-5mg 5mg Ask for price
Description: (S)-MCPG

(RS)-MCPG

MBS579609-10mg 10mg
EUR 180

(RS)-MCPG

MBS579609-25mg 25mg
EUR 275

(RS)-MCPG

MBS579609-2mg 2mg
EUR 145

(RS)-MCPG

MBS579609-50mg 50mg
EUR 410

(RS)-MCPG

MBS579609-5mg 5mg
EUR 160

(S)-MCPG

MBS3844992-100mg 100mg
EUR 825

(S)-MCPG

MBS3844992-10mg 10mg
EUR 200

(S)-MCPG

MBS3844992-50mg 50mg
EUR 440

(S)-MCPG

MBS3844992-5mg 5mg
EUR 155

(S)-MCPG

MBS3844992-5x100mg 5x100mg
EUR 3695

(RS)-MCPG

MBS3845259-100mg 100mg
EUR 910

(RS)-MCPG

MBS3845259-10mg 10mg
EUR 210

(RS)-MCPG

MBS3845259-50mg 50mg
EUR 485

(RS)-MCPG

MBS3845259-5mg 5mg
EUR 165

(RS)-MCPG

MBS3845259-5x100mg 5x100mg
EUR 4085

(RS)-MCPG

MBS3607307-10mg 10mg
EUR 245

(RS)-MCPG

MBS3607307-25mg 25mg
EUR 340

(RS)-MCPG

MBS3607307-2mg 2mg
EUR 200

(RS)-MCPG

MBS3607307-50mg 50mg
EUR 475

(RS)-MCPG

MBS3607307-5mg 5mg
EUR 220

(S)-MCPG

MBS5754201-200mg 200mg
EUR 1055

(S)-MCPG

MBS5754201-5x200mg 5x200mg
EUR 4610

MCPG (sodium)

HY-103570 Get quote Ask for price
Description: MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) [1].

(RS)-MCPG disodium salt

B7476-10 10 mg
EUR 126
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-100 100mg
EUR 900
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-25 25mg
EUR 278
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-5 5mg
EUR 91
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

B7476-50 50 mg
EUR 490
Description: group I/group II metabotropic glutamate receptor antagonist

(RS)-MCPG disodium salt

T23270-10mg 10mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-1g 1g Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-1mg 1mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-50mg 50mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

T23270-5mg 5mg Ask for price
Description: (RS)-MCPG disodium salt

(RS)-MCPG disodium salt

MBS5757736-50mg 50mg
EUR 1140

(RS)-MCPG disodium salt

MBS5757736-5x50mg 5x50mg
EUR 4970

Avidin 50mg

IB2-0204-050 each
EUR 274.68

Mitomycin C, 50mg

R5007 50mg
EUR 1190.08

Mitomycin C, 50mg

R5007-50mg each
EUR 1712.4

Gentamicin, 50mg/ml

CA003-001 10ml
EUR 109.2

Kanamycin (50mg/ml, 1000X)

K2802-10 10x1ml
EUR 64
Description: Cell Biology|Cell Culture

Kanamycin (50mg/ml, 1000X)

K2802-5 5x1ml
EUR 40
Description: Cell Biology|Cell Culture

MUG Supplement (50mg/vl)

26834 5 vl
EUR 16.25
Description: Part D

Timentin Solution, 50mg/mL

40110059-1 20 mL
EUR 23.8

Timentin Solution, 50mg/mL

40110059-2 50 mL
EUR 33.86

Timentin Solution, 50mg/mL

40110059-3 100 mL
EUR 44.84

Kanamycin solution (50mg/ml)

MN800A-1 20 ml
EUR 75

Gentamicin Solution, 50mg/mL

25-533 10 mL/Unit
EUR 19.67
Description: Sterile Solution

Ampicillin Solution 50mg/ml

MBS651582-20mL 20mL
EUR 135

Ampicillin Solution 50mg/ml

MBS651582-5x20mL 5x20mL
EUR 215

Cycloheximide Solution 50mg/ml

MBS651240-20mL 20mL
EUR 195

Cycloheximide Solution 50mg/ml

MBS651240-5x20mL 5x20mL
EUR 540

Lactobacilli Supplement (50mg/vl)

39785 5 vl
EUR 12.83
Description: Part D

Lactobacilli Supplement (50mg/vl)

39785-1 5 x5 vl
EUR 39.34
Description: Part D

50mg/mL G-418 Solution

PB180125-10mL 10 mL
EUR 55
Description: Supplements & Reagents

50mg/mL G-418 Solution

PB180125 10mL
EUR 55
Description: Antibiotics

50mg/mL G-418 Solution

MBS2567645-10mL 10mL
EUR 125

50mg/mL G-418 Solution

MBS2567645-5x10mL 5x10mL
EUR 545

50mg Blasticidin S HCl - EACH

30-100-RB EACH
EUR 260.55

G418 Sulfate, 50mg/mL, Sterile

40710027-1 20 mL
EUR 85.98

B.P. Sulpha Supplement (50mg/vl)

15097 5 vl
EUR 9.41
Description: Part D

50mg/mL Hygromycin B Solution

PB180126-10mL 10 mL
EUR 88
Description: Supplements & Reagents

50mg/mL Hygromycin B Solution

PB180126 10mL
EUR 88
Description: Antibiotics

Protein A, Recombinant, 50mg/ml

MBS638222-100mg 100mg
EUR 345

Protein A, Recombinant, 50mg/ml

MBS638222-25mg 25mg
EUR 220

Protein A, Recombinant, 50mg/ml

MBS638222-500mg 500mg
EUR 1205

Protein A, Recombinant, 50mg/ml

MBS638222-5x500mg 5x500mg
EUR 5280

Hygromycin B 50mg/ml Solution

MBS651334-10x1mL 10x1mL
EUR 395

Hygromycin B 50mg/ml Solution

MBS651334-1mL 1mL
EUR 160

Hygromycin B 50mg/ml Solution

MBS651334-5x1mL 5x1mL
EUR 285

50mg/mL Hygromycin B Solution

MBS2570243-10mL 10mL
EUR 145

50mg/mL Hygromycin B Solution

MBS2570243-5x10mL 5x10mL
EUR 635

Neomycin Sulfate Solution 50mg/ml

MBS651502-20x20mL 20x20mL
EUR 530

Neomycin Sulfate Solution 50mg/ml

MBS651502-5x20mL 5x20mL
EUR 195

Kanamycin Sulfate Solution(50mg/ml)

11981-04 20ML
EUR 42

Perfringens Supplement-I (50mg/vl)

11976 5 vl
EUR 7.7
Description: Part D

Perfringens Supplement-I (50mg/vl)

11976-1 5 x5 vl
EUR 20.53
Description: Part D

Deoxyribonuclease I (DNase I), 50mg

PC0704-50mg each Ask for price

Kanamycin Sulfate 50mg/ml Solution

MBS651522-10x20mL 10x20mL
EUR 345

Kanamycin Sulfate 50mg/ml Solution

MBS651522-5x20mL 5x20mL
EUR 260

Gentamicin Sulfate Solution(50mg/ml)

11980-14 10ML
EUR 56

Erythromycin Solution, 50mg/mL, Sterile

40120785-1 25 mL
EUR 24.71

Erythromycin Solution, 50mg/mL, Sterile

40120785-2 50 mL
EUR 39.35

Erythromycin Solution, 50mg/mL, Sterile

40120785-3 100 mL
EUR 72.29

Oxytetra Selective Supplement (50mg/vl)

51521 5 vl
EUR 7.7
Description: Part D

Oxytetra Selective Supplement (50mg/vl)

51521-1 5 x5 vl
EUR 24.8
Description: Part D

Chloramphenicol Solution, 50mg/mL, Sterile

40110067-1 10 mL
EUR 31.67

Chloramphenicol Solution, 50mg/mL, Sterile

40110067-2 25 mL
EUR 45.48

Bacteroides Selective Supplement (50mg/vl)

83141 5 vl
EUR 9.41
Description: Part D

Chloramphenicol Selective Supplement (50mg/vl)

14602 5 vl
EUR 9.41
Description: Part D

Chloramphenicol Selective Supplement (50mg/vl)

14602-1 5 x5 vl
EUR 27.37
Description: Part D

Cy3 Bis Nhs Ester 50Mg - EACH

PA13002 EACH
EUR 9913.05

Goat Anti-Mouse IgG Fc, 50MG

A008-50MG 50MG
EUR 1022.42

Goat Anti-Rabbit IgG Fc, 50MG

A009-50MG 50MG
EUR 1022.42

Wire Weight 50mg E2 Dakks - EACH

YCW152102 EACH
EUR 168.75

Hygromycin B Solution, 50mg/mL, Sterile

40810004-1 25 mL
EUR 80.99

Hygromycin B Solution, 50mg/mL, Sterile

40810004-2 50 mL
EUR 150.08

Neomycin Sulfate Solution, 50mg/mL, Sterile

40110068-1 10 mL
EUR 31.67

Neomycin Sulfate Solution, 50mg/mL, Sterile

40110068-2 25 mL
EUR 45.48

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-1 25 mL
EUR 31.57

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-2 50 mL
EUR 52.71

Kanamycin Sulfate Solution, 50mg/mL, Sterile

40110064-3 100 mL
EUR 73.01

Gentamicin Sulfate Solution, 50mg/mL, Sterile

40710024-1 20 mL
EUR 44.92

Gentamicin Sulfate Solution, 50mg/mL, Sterile

40710024-2 100 mL
EUR 112.16

Recombinant Bovine ATF Protein, Untagged, -50mg

QP11095-50mg 50mg
EUR 186

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-1 10 mL
EUR 12.81

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-2 25 mL
EUR 19.22

Streptomycin Sulfate Solution, 50mg/mL, Sterile

40121057-3 50 mL
EUR 35.69

Gentamycin (Gentamicin) Sulfate Solution 50mg/ml

MBS651312-10x20mL 10x20mL
EUR 970

Gentamycin (Gentamicin) Sulfate Solution 50mg/ml

MBS651312-20mL 20mL
EUR 220

Gentamycin (Gentamicin) Sulfate Solution 50mg/ml

MBS651312-5x20mL 5x20mL
EUR 610

X-Gal Solution, 50mg/mL in DMF

21530036-1 2 mL
EUR 57.59

X-Gal Solution, 50mg/mL in DMF

21530036-2 5 mL
EUR 85.98

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-1 10 mL
EUR 26.54

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-2 25 mL
EUR 53.99

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile

40121047-3 50 mL
EUR 89.68

C18(EC) 50mg/1mL SPE Columns - PK100

CHR5622 PK100
EUR 234.9

Standard Nitrile 50mg/L as N - 1L

SDN0501 1L
EUR 443.58

Donkey Anti-Sheep IgG (H&L), 50MG

A010-50MG 50MG
EUR 1022.42

C18(EC) 50mg Fixed-well Plate - EACH

CHR5624 EACH
EUR 336.15

Amersham Cy5 Bis NHS ester 50mg - EACH

PA15002 EACH
EUR 7708.5

Amersham Cy5 mono NHS ester 50mg - EACH

PA15102 EACH
EUR 9413.55

Amersham Cy55 Bis NHS ester 50mg - EACH

PA15502 EACH
EUR 9478.35

Caffeine Standard 50mg/L in Water - 5ML

CAFSTD50005 5ML
EUR 492.75

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-1 25 mL
EUR 35.21

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-2 50 mL
EUR 57.89

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile

40120723-3 100 mL
EUR 76.66

Spectropho Pot Dichro A/T Std 50mg/L - 100ML

RSPEC00201 100ML
EUR 286.2

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-1 10 mL
EUR 17.39

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-2 25 mL
EUR 26.54

Carbenicillin Disodium Salt Solution, 50mg/mL, Sterile

40120745-3 100 mL
EUR 61.8

Recombinant Multi Species ACTH Protein, Untagged, -50mg

QP10950-50mg 50mg
EUR 663.6

Peracetic Acid Indicator Strips 0-50mg/L - PK100

PAP1234 PK100
EUR 27

Alkalinity Std 50mg/L 50ppm as CaCO3 - 1L

TA0501 1L
EUR 442.8

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile Tubes

40121048-1 25 tube(s) Ask for price

Spectinomycin Dihydrochloride Solution, 50mg/mL, Sterile Tubes

40121048-2 50 tube(s) Ask for price

Kinesis TELOS QuEChERS Clean-up Kit Dispersive Pigmented Fruit and Veg; AOAC 2007.01; 150mg MgSO4 50mg PSA 50mg PestiCarb; 2ml - PK100

CHR6487 PK100
EUR 284.85

IC Anion Std Nitrate 50mg/L in H2O - 500ML

ICAA04 500ML
EUR 132.19

IC Cation Std Ammonium 50mg/L in H2O - 500ML

ICCA01 500ML
EUR 132.19

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

40120724-1 25 tube(s) Ask for price

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

40120724-2 50 tube(s) Ask for price

Ampicillin Sodium Salt Solution, 50mg/mL, Sterile Tubes

40120724-3 100 tube(s) Ask for price

BioMag® Dextran-coated Charcoal Concentrate (50mg/ml)

84555-1 1l
EUR 1759

G418 Sulfate (Geneticin) 50mg/ml Solution, Sterile-filtered

MBS651498-20mL 20mL
EUR 195

G418 Sulfate (Geneticin) 50mg/ml Solution, Sterile-filtered

MBS651498-5x20mL 5x20mL
EUR 555

Hygromycin B (HGR Solution), 50mg/ml in Aq. Solution

94663 20 ml
EUR 73.5
Description: Part B

OOMC00003-50MG - Astemizole

OOMC00003-50MG 50mg
EUR 99

OOMC00007-50MG - Rapamycin

OOMC00007-50MG 50mg
EUR 249

OOMC00025-50MG - Entacapone

OOMC00025-50MG 50mg
EUR 159

OOMC00030-50MG - Valinomycin

OOMC00030-50MG 50mg
EUR 189

OOMC00040-50MG - Ebselen

OOMC00040-50MG 50mg
EUR 89

OOMC00042-50MG - Leflunomide

OOMC00042-50MG 50mg
EUR 59

OOMC00043-50MG - Auranofin

OOMC00043-50MG 50mg
EUR 69

OOMC00053-50MG - Omeprazole

OOMC00053-50MG 50mg
EUR 59

OOMC00054-50MG - Emetine

OOMC00054-50MG 50mg
EUR 69

OOMC00060-50MG - Tigecycline

OOMC00060-50MG 50mg
EUR 269

OOMC00074-50MG - Umifenovir

OOMC00074-50MG 50mg
EUR 249

OOMC00076-50MG - Ritonavir

OOMC00076-50MG 50mg
EUR 199

OOMC00080-50MG - Nitazoxanide

OOMC00080-50MG 50mg
EUR 199

OOMC00081-50MG - Trametinib

OOMC00081-50MG 50mg
EUR 199

OOMC00088-50MG - Cepharanthine

OOMC00088-50MG 50mg
EUR 59

OOAU00078-50MG - HPA

OOAU00078-50MG 50mg
EUR 299

OOAU00085-50MG - Decitabine

OOAU00085-50MG 50mg
EUR 539

OOAU00091-50MG - Xanthohumol

OOAU00091-50MG 50mg
EUR 1049

Spectropho Pot Dichro A/T Std 50mg/L in Cuvs - PK2

RSPEC0020 PK2
EUR 1571.4

ICP Multi Elem (12) Tuning Std in 2% HNO3 50mg/L each - 100ML

ICP12-50-100 100ML
EUR 550.8

Zymolyase 20T Concentrate 50mg/ml, 0.1M Sorbitol (Lyticase, Yeast Lytic Enzyme)

MBS653686-1mL 1mL
EUR 185

Zymolyase 20T Concentrate 50mg/ml, 0.1M Sorbitol (Lyticase, Yeast Lytic Enzyme)

MBS653686-5x1mL 5x1mL
EUR 395

OOMA00041-50MG - Sheep IgG

OOMA00041-50MG 0.05g
EUR 259

OOMC00004-50MG - U-18666A

OOMC00004-50MG 50mg
EUR 379

OOMC00005-50MG - Nafamostat mesylate

OOMC00005-50MG 50mg
EUR 269

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.