cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

Recombinant other Terlipressin Protein, Untagged, E.coli-50mg
QP13723-50mg 50mg
EUR 363

Recombinant Human CTRB1 Protein, Untagged, E.coli-50mg
QP10565-50mg 50mg
EUR 563

Recombinant Yeast IDH1 Protein, Untagged, Yeast-50mg
QP10670-50mg 50mg
EUR 1043

Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg
QP12314-50mg 50mg
EUR 201

Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg
QP12317-50mg 50mg
EUR 363

Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg
QP10897-50mg 50mg
EUR 962

Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg
QP10899-50mg 50mg
EUR 563

Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg
QP10544-50mg 50mg
EUR 517

Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg
QP12316-50mg 50mg
EUR 363

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg
QP11479-50mg 50mg
EUR 926

(RS)-MCPG
HY-100371 100mg
EUR 946

(S)-MCPG
HY-100406 5mg
EUR 133

(RS)-MCPG
B6265-10 10 mg
EUR 248

(RS)-MCPG
B6265-100 100 mg
EUR 1497

(RS)-MCPG
B6265-25 25 mg
EUR 502

(RS)-MCPG
B6265-5 5 mg
EUR 195

(RS)-MCPG
B6265-5.1 10 mM (in 1mL DMSO)
EUR 209

(RS)-MCPG
B6265-50 50 mg
EUR 846

(S)-MCPG
B6266-10 10 mg
EUR 176

(S)-MCPG
B6266-25 25 mg
EUR 350

(S)-MCPG
B6266-5 5 mg
EUR 116

DiA: (50mg)
60013 50MG
EUR 210
Description: Minimum order quantity: 1 unit of 50MG

L-NMMA: (50mg)
00224 25MG
EUR 207
Description: Minimum order quantity: 1 unit of 25MG

Gentamicin, 50mg/ml
CA003-001 10ml
EUR 91

(RS)-MCPG disodium salt
B7476-10 10 mg
EUR 302

(RS)-MCPG disodium salt
B7476-50 50 mg
EUR 1114

DiOC14(3), hydroxyethanesulfonate: (50mg)
60012 50MG
EUR 153
Description: Minimum order quantity: 1 unit of 50MG

Biotin-12, SE: (50mg)
90083 50MG
EUR 193
Description: Minimum order quantity: 1 unit of 50MG

Kanamycin solution (50mg/ml)
MN800A-1 20 ml
EUR 127

DiD (or DiIC18(5)): (50mg)
60014 50MG
EUR 161
Description: Minimum order quantity: 1 unit of 50MG

Actinomycin D
1036-50MG
EUR 533

Camptothecin
1039-50MG
EUR 153

Sulfo-Cyanine7.5 dicarboxylic acid, 50 mg
1382-50mg 50 mg
EUR 921

BDP R6G azide, 50 mg
1476-50mg 50 mg
EUR 501

sulfo-Cyanine7 dicarboxylic acid, 50 mg
1497-50mg 50 mg
EUR 921

Cyanine7 dicarboxylic acid, 50 mg
1512-50mg 50 mg
EUR 501

IGF-I, human recombinant
4119-50MG
EUR 4220

R³ IGF-1, human recombinant
4216-50MG
EUR 3470

SAHA (Vorinostat )
P004-50MG 50MG
EUR 119
Description: CAS: 149647-78-9

HPA (Hexyl-4-pentynoic acid )
P008-50MG 50MG
EUR 311
Description: CAS: 96017-59-3

5-Azacytidine
P012-50MG 50MG
EUR 86
Description: CAS: 320-67-2

Decitabine
P015-50MG 50MG
EUR 539
Description: CAS: 2353-33-5

BRL-50481
P020-50MG 50 mg
EUR 441
Description: CAS: 433695-36-4

Xanthohumol
P021-50MG 50MG
EUR 1001
Description: CAS: 6754-58-1

Aztreonam
A017-50MG 50 mg
EUR 115

Acyclovir (Acycloguanosine)
A090-50MG 50 mg
EUR 127

(E)-3α-hydroxy-6-ethylidene-7-keto-5β-cholan-24-oic acid
abx186093-50mg 50 mg
EUR 300

dabigatran
abx186421-50mg 50 mg
EUR 425

Irinotecan
abx188740-50mg 50 mg
EUR 314

Cefepime
C008-50MG 50 mg
EUR 438

Cefprozil
C017-50MG 50 mg
EUR 511

Rabbit Anti-Human IgM （u chain）
C020210-50mg 50mg
EUR 6015

Goat Anti-Human IgM（u chain）
C020213-50mg 50mg
EUR 2635

Goat Anti-Human IgG FC
C020220-50mg 50mg
EUR 6015

Rabbit Anti-Human IgG FC
C020221-50mg 50mg
EUR 6015

Goat Anti-Human IgG Fab
C020233-50mg 50mg
EUR 2635

Goat Anti-Human IgG (γ chain)
C020234-50mg 50mg
EUR 2635

Rabbit Anti-Human IgG (γ chain)
C020235-50mg 50mg
EUR 2635

Goat Anti-Human IgG F(AB)2
C020238-50mg 50mg
EUR 2635

Goat Anti-Tree shrew IgG(H+L)
C020239-50mg 50mg
EUR 2635

Rabbit Anti-Human IgG F(AB)2
C020240-50mg 50mg
EUR 2635

Goat Anti-Human IgA
C020242-50mg 50mg
EUR 2635

Clindamycin Hydrochloride
C035-50MG 50 mg
EUR 127

Clindamycin Phosphate
C036-50MG 50 mg
EUR 119

Camptothecin (Camptotheca acuminata)
C070-50MG 50 mg
EUR 77

Cefotiam Dihydrochloride
C095-50MG 50 mg
EUR 144

Camptothecin (Mappia foetida)
C145-50MG 50 mg
EUR 77

Camptothecin sodium
C146-50MG 50 mg
EUR 80

Cidofovir dihydrate
C202-50MG 50 mg
EUR 219

Bleomycin A5 hydrochloride
B004-50MG 50 mg
EUR 397

Bleomycin sulfate USP
B005-50MG 50 mg
EUR 575

Brefeldin A
B012-50MG 50 mg
EUR 335

Bithionol
B035-50MG 50 mg
EUR 72

Bleomycin
B053-50MG 50 mg
EUR 708

Biapenem
B080-50MG 50mg
EUR 198

(R)-(+)-7,7'-Bis(Diphenylphosphino)-2,2',3,3'-Tetrahydro-1,1'-Spirobiindane
abx180110-50mg 50 mg
EUR 398

Cafenstrole
abx185370-50mg 50 mg
EUR 606

Chicken IgY Protein
abx060688-50mg 50 mg
EUR 551

SL-01
abx076822-50mg 50 mg
EUR 272

Leflunomide
abx076826-50mg 50 mg
EUR 230

Auranofin
abx076835-50mg 50 mg
EUR 272

Horseradish Peroxidase Antibody
abx022688-50mg 50 mg
EUR 954

Aldolase (Rabbit Muscle) Antibody
abx022821-50mg 50 mg
EUR 1052

Carbonic Anhydrase II (CA2) Antibody
abx022828-50mg 50 mg
EUR 857

Elastase Antibody
abx022830-50mg 50 mg
EUR 857

Glucose Oxidase Antibody
abx022832-50mg 50 mg
EUR 1052

Papain (Carica papaya) Antibody
abx022844-50mg 50 mg
EUR 899

Atovaquone
A099-50MG 50 mg
EUR 239

Telithromycin
T015-50MG 50 mg
EUR 291

Tedizolid
T117-50MG 50mg
EUR 481

Tedizolid Phosphate
T118-50MG 50mg
EUR 180

Tipiracil Hydrochloride
T121-50MG 50mg
EUR 340

Tolvaptan
T125-50MG 50mg
EUR 429

Tenofovir Alafenamide
T128-50MG 50mg
EUR 144

Phenyl b-D-thioglucopyranoside
GC0722-50MG 50 mg
EUR 70

b-D-Allopyranose
GC0862-50MG 50 mg
EUR 61

5-Bromo-4-chloro-3-indolyl b-D-xylopyranoside
GC1526-50MG 50 mg
EUR 94

Methyl N-acetyl-alpha-D-glucosaminide
GC2856-50MG 50 mg
EUR 142

Maltohexaose
GC2935-50MG 50 mg
EUR 86

5-Bromo-4-chloro-3-indolyl b-D-galactopyranoside
GC3237-50MG 50 mg
EUR 54

XTT sodium salt
GC5281-50MG 50 mg
EUR 142

Quercetin 3-b-D-glucoside
GC9169-50MG 50 mg
EUR 114

Spiperone hydrochloride
GE2928-50MG 50 mg
EUR 154

AEBSF hydrochloride
GE4678-50MG 50 mg
EUR 114

5-Methyl-2'-deoxycytidine
GE5158-50MG 50 mg
EUR 75

Asiaticoside
GC7829-50MG 50 mg
EUR 344

Stevioside
GC8309-50MG 50 mg
EUR 367

Trifluridine
GE1913-50MG 50 mg
EUR 102

Actinomycin D
GA0481-50MG 50 mg
EUR 174

Ascomycin
GA1406-50MG 50 mg
EUR 285

Mupirocin
GA2184-50MG 50 mg
EUR 82

Flumethasone
GA2414-50MG 50 mg
EUR 70

Telithromycin
GA2425-50MG 50 mg
EUR 150

Linezolid
GA2609-50MG 50 mg
EUR 126

Brefeldin A
GA2848-50MG 50 mg
EUR 389

Doxorubicin hydrochloride
GA4969-50MG 50 mg
EUR 126

Torezolid
GA5035-50MG 50 mg
EUR 90

Pimaricin
GA5100-50MG 50 mg
EUR 50

Ribavirin
GA5462-50MG 50 mg
EUR 62

Phleomycin
GA6020-50MG 50 mg
EUR 269

Biapenem
GA6808-50MG 50 mg
EUR 78

Vinblastine sulfate
GA7194-50MG 50 mg
EUR 389

Rapamycin
GA7417-50MG 50 mg
EUR 150

Ceftibuten hydrate
GA7818-50MG 50 mg
EUR 120

Mitomycin C
GA9147-50MG 50 mg
EUR 269

Moxifloxacin hydrochloride
GA9781-50MG 50 mg
EUR 54

Ribonuclease A, DNase free
GE9871-50MG 50 mg
EUR 107

PD 98,059
GK2140-50MG 50 mg
EUR 378

Aminopterin dihydrate
GK2974-50MG 50 mg
EUR 107

Pravastatin sodium salt
GK3699-50MG 50 mg
EUR 110

alpha-Mangostin
GK4316-50MG 50 mg
EUR 269

3-Morpholinosydnonimine hydrochloride
GK4946-50MG 50 mg
EUR 200

H-8 dihydrochloride
GK6037-50MG 50 mg
EUR 252

Ro 61-8048
GK6422-50MG 50 mg
EUR 548

Cisapride monohydrate
GL0434-50MG 50 mg
EUR 229

AdipoRon hydrochloride
GL0874-50MG 50 mg
EUR 459

Mephenytoin
GL1129-50MG 50 mg
EUR 429

1H-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
GL1507-50MG 50 mg
EUR 321

MTSSL
GL1695-50MG 50 mg
EUR 436

Tocainide hydrochloride
GL2205-50MG 50 mg
EUR 429

Thonzonium bromide
GL2255-50MG 50 mg
EUR 166

WY-14643
GL2940-50MG 50 mg
EUR 154

Compound 112254
GL3740-50MG 50 mg
EUR 459

Cyclic Pifithrin-alpha hydrobromide
GL3913-50MG 50 mg
EUR 528

Shikonin
GL5964-50MG 50 mg
EUR 269

TOFA
GL6289-50MG 50 mg
EUR 198

4-Aminophenylphosphate sodium salt
GL6836-50MG 50 mg
EUR 252

N,N,N',N'-Tetrakis(2-pyridylmethyl)ethylenediamine
GK2289-50MG 50 mg
EUR 77

SC-560
GK2799-50MG 50 mg
EUR 349

Piperlongumine
GK8547-50MG 50 mg
EUR 223

Bay 11-7082
GK8638-50MG 50 mg
EUR 413

PK 11195
GL4857-50MG 50 mg
EUR 321

MnTBAP chloride
GL5377-50MG 50 mg
EUR 154

AdipoRon
GL6438-50MG 50 mg
EUR 390

Epicoprostanol
GL6737-50MG 50 mg
EUR 137

Zerumbone
GL7258-50MG 50 mg
EUR 298

GYY 4137
GL7524-50MG 50 mg
EUR 321

L-Alanyl-L-1-aminoethylphosphonic acid
GL8388-50MG 50 mg
EUR 158

Corosolic acid
GL8496-50MG 50 mg
EUR 668

MnTMPyP pentachloride
GL8780-50MG 50 mg
EUR 154

Compound 112254 hydrochloride
GL8859-50MG 50 mg
EUR 459

Ketanserin (+)-tartrate salt
GL9943-50MG 50 mg
EUR 172

Bay 60-7550
GN2518-50MG 50 mg
EUR 2582

5-(E)-(2-Bromovinyl)-2'-deoxyuridine
GN2626-50MG 50 mg
EUR 150

3'-O-Methylguanosine
GN3227-50MG 50 mg
EUR 190

N1-Methyladenosine
GN7727-50MG 50 mg
EUR 269

Pseudouridine
GN9104-50MG 50 mg
EUR 128

Rizatriptan benzoate
GP0042-50MG 50 mg
EUR 150

Suramin sodium salt
GP0138-50MG 50 mg
EUR 110

Rofecoxib
GP0159-50MG 50 mg
EUR 86

Epigallocatechin gallate
GP0260-50MG 50 mg
EUR 72

Betaxolol hydrochloride
GP0555-50MG 50 mg
EUR 110

Tonabersat
GP0580-50MG 50 mg
EUR 628

Salmeterol xinafoate
GP0706-50MG 50 mg
EUR 94

Boceprevir
GP0844-50MG 50 mg
EUR 778

Perindopril erbumine
GP1522-50MG 50 mg
EUR 92

Valaciclovir hydrochloride
GP1612-50MG 50 mg
EUR 46

Forskolin
GP2059-50MG 50 mg
EUR 309

Gatifloxacin hydrate
GP2111-50MG 50 mg
EUR 90

Sunitinib malate
GP2160-50MG 50 mg
EUR 102

Methysergide maleate salt
GP2886-50MG 50 mg
EUR 668

Bosentan hydrate
GP5893-50MG 50 mg
EUR 130

Carmofure
GP5925-50MG 50 mg
EUR 154

Zafirlukast
GP6218-50MG 50 mg
EUR 110

Tolazamide
GP6227-50MG 50 mg
EUR 237

Lopinavir
GP6351-50MG 50 mg
EUR 70

Acadesine
GP6637-50MG 50 mg
EUR 154

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.