In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis

cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg
QP12522-50mg	EnQuireBio	50mg	EUR 4386

Recombinant other Terlipressin Protein, Untagged, E.coli-50mg
QP13723-50mg	EnQuireBio	50mg	EUR 435.6

Recombinant other Exenatide Protein, Untagged, E.coli-50mg
QP11816-50mg	EnQuireBio	50mg	EUR 2829.6

Recombinant Rat Carboxypeptidase B Protein, Untagged, E.coli-50mg
QP10544-50mg	EnQuireBio	50mg	EUR 620.4

Recombinant Porcine Trypsin Protein, Untagged, Pichia Pastoris-50mg
QP10897-50mg	EnQuireBio	50mg	EUR 1154.4

Recombinant Human Trypsin-2 Protein, Untagged, E.coli-50mg
QP10899-50mg	EnQuireBio	50mg	EUR 675.6

Recombinant other HSA Protein, Untagged, Pichia Pastoris-50mg
QP12314-50mg	EnQuireBio	50mg	EUR 241.2

Recombinant other HSA Recombinant Protein, Untagged, Rice-50mg
QP12317-50mg	EnQuireBio	50mg	EUR 435.6

Recombinant Human Collagen-III Protein, Untagged, Pichia Pastoris-50mg
QP11479-50mg	EnQuireBio	50mg	EUR 1111.2

Recombinant other HSA Lipid free Protein, Untagged, Rice-50mg
QP12316-50mg	EnQuireBio	50mg	EUR 435.6

(RS)-MCPG
B6265-10	ApexBio	10 mg	EUR 297.6

(RS)-MCPG
B6265-100	ApexBio	100 mg	EUR 1796.4

(RS)-MCPG
B6265-25	ApexBio	25 mg	EUR 602.4

(RS)-MCPG
B6265-5	ApexBio	5 mg	EUR 234

(RS)-MCPG
B6265-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 250.8

(RS)-MCPG
B6265-50	ApexBio	50 mg	EUR 1015.2

(S)-MCPG
B6266-10	ApexBio	10 mg	EUR 211.2

(S)-MCPG
B6266-25	ApexBio	25 mg	EUR 420

(S)-MCPG
B6266-5	ApexBio	5 mg	EUR 139.2

(RS)-MCPG
HY-100371	MedChemExpress	100mg	EUR 1135.2

(S)-MCPG
HY-100406	MedChemExpress	5mg	EUR 159.6

DiA: (50mg)
60013	Biotium	50MG	EUR 252
Description: Minimum order quantity: 1 unit of 50MG

(RS)-MCPG disodium salt
B7476-10	ApexBio	10 mg	EUR 362.4

(RS)-MCPG disodium salt
B7476-50	ApexBio	50 mg	EUR 1336.8

Gentamicin, 50mg/ml
CA003-001	GenDepot	10ml	EUR 109.2

L-NMMA: (50mg)
00224	Biotium	25MG	EUR 248.4
Description: Minimum order quantity: 1 unit of 25MG

Biotin-12, SE: (50mg)
90083	Biotium	50MG	EUR 231.6
Description: Minimum order quantity: 1 unit of 50MG

Kanamycin solution (50mg/ml)
MN800A-1	SBI	20 ml	EUR 152.4

50mg Blasticidin S HCl
30-100-RB	Scientific Laboratory Supplies	EACH	EUR 220.02

DiD (or DiIC18(5)): (50mg)
60014	Biotium	50MG	EUR 193.2
Description: Minimum order quantity: 1 unit of 50MG

Cy3 Bis Nhs Ester 50Mg
PA13002	Scientific Laboratory Supplies	EACH	EUR 7407.72

Wire Weight 50mg E2 Dakks
YCW152102	Scientific Laboratory Supplies	EACH	EUR 127.68

Amersham Cy5 Bis NHS ester 50mg
PA15002	Scientific Laboratory Supplies	EACH	EUR 5760.42

Amersham Cy5 mono NHS ester 50mg
PA15102	Scientific Laboratory Supplies	EACH	EUR 7033.8

Amersham Cy55 Bis NHS ester 50mg
PA15502	Scientific Laboratory Supplies	EACH	EUR 7082.82

Standard Nitrile 50mg/L as N
SDN0501	Scientific Laboratory Supplies	1L	EUR 315.78

C18(EC) 50mg/1mL SPE Columns
CHR5622	Scientific Laboratory Supplies	PK100	EUR 156.18

Caffeine Standard 50mg/L in Water
CAFSTD50005	Scientific Laboratory Supplies	5ML	EUR 356.82

C18(EC) 50mg Fixed-well Plate
CHR5624	Scientific Laboratory Supplies	EACH	EUR 221.16

Peracetic Acid Indicator Strips 0-50mg/L
PAP1234	Scientific Laboratory Supplies	PK100	EUR 19.17

Alkalinity Std 50mg/L 50ppm as CaCO3
TA0501	Scientific Laboratory Supplies	1L	EUR 320.34

IC Anion Std Nitrate 50mg/L in H2O
ICAA04	Scientific Laboratory Supplies	500ML	EUR 93.48

IC Cation Std Ammonium 50mg/L in H2O
ICCA01	Scientific Laboratory Supplies	500ML	EUR 93.48

Spectropho Pot Dichro A/T Std 50mg/L
RSPEC00201	Scientific Laboratory Supplies	100ML	EUR 205.2

Kinesis TELOS QuEChERS Clean-up Kit Dispersive Pigmented Fruit and Veg; AOAC 2007.01; 150mg MgSO4 50mg PSA 50mg PestiCarb; 2ml
CHR6487	Scientific Laboratory Supplies	PK100	EUR 189.24

Bml 277
20-abx076616	Abbexa	EUR 376.80 EUR 910.80	10 mg 50 mg

SMER3
20-abx076619	Abbexa	EUR 376.80 EUR 927.60	10 mg 50 mg

Actinomycin D
20-abx076620	Abbexa	EUR 393.60 EUR 927.60	10 mg 50 mg

Mitomycin C
20-abx076621	Abbexa	EUR 376.80 EUR 927.60	10 mg 50 mg

LDN-57444
20-abx076622	Abbexa	EUR 376.80 EUR 927.60	10 mg 50 mg

Doxorubicin Hydrochloride
20-abx076623	Abbexa	EUR 410.40 EUR 944.40	10 mg 50 mg

Fasudil
20-abx076624	Abbexa	EUR 393.60 EUR 978.00	10 mg 50 mg

Pyr3
20-abx076630	Abbexa	EUR 427.20 EUR 1011.60	10 mg 50 mg

SB-366791
20-abx076632	Abbexa	EUR 376.80 EUR 1028.40	10 mg 50 mg

Forskolin
20-abx076633	Abbexa	EUR 376.80 EUR 1045.20	10 mg 50 mg

E-4031
20-abx076635	Abbexa	EUR 444.00 EUR 1062.00	10 mg 50 mg

Nigericin
20-abx076636	Abbexa	EUR 460.80 EUR 1078.80	10 mg 50 mg

KB-R7943 mesylate
20-abx076637	Abbexa	EUR 427.20 EUR 1078.80	10 mg 50 mg

P32 / 98
20-abx076640	Abbexa	EUR 393.60 EUR 1095.60	10 mg 50 mg

R(-)-Gossypol
20-abx076641	Abbexa	EUR 427.20 EUR 1111.20	10 mg 50 mg

Celastrol
20-abx076642	Abbexa	EUR 444.00 EUR 1111.20	10 mg 50 mg

NSC-66811
20-abx076643	Abbexa	EUR 427.20 EUR 1144.80	10 mg 50 mg

JX 401
20-abx076645	Abbexa	EUR 460.80 EUR 1228.80	10 mg 50 mg

GW 441756
20-abx076646	Abbexa	EUR 460.80 EUR 1262.40	10 mg 50 mg

Kainic acid
20-abx076647	Abbexa	EUR 444.00 EUR 1262.40	10 mg 50 mg

Deguelin
20-abx076648	Abbexa	EUR 493.20 EUR 1296.00	10 mg 50 mg

BC-11-38
20-abx076649	Abbexa	EUR 444.00 EUR 1296.00	10 mg 50 mg

PJ-34
20-abx076650	Abbexa	EUR 510.00 EUR 1345.20	10 mg 50 mg

Quisqualic Acid
20-abx076651	Abbexa	EUR 510.00 EUR 1412.40	10 mg 50 mg

Xanthohumol
20-abx076653	Abbexa	EUR 510.00 EUR 1462.80	10 mg 50 mg

Retinoic acid
20-abx076656	Abbexa	EUR 292.80 EUR 243.60	250 mg 50 mg

2-APB
20-abx076657	Abbexa	EUR 343.20 EUR 260.40	250 mg 50 mg

5-Azacytidine
20-abx076660	Abbexa	EUR 376.80 EUR 260.40	250 mg 50 mg

Puromycin HCl
20-abx076662	Abbexa	EUR 526.80 EUR 276.00	250 mg 50 mg

Clozapine
20-abx076666	Abbexa	EUR 493.20 EUR 276.00	250 mg 50 mg

Itraconazole
20-abx076667	Abbexa	EUR 510.00 EUR 276.00	250 mg 50 mg

Nicardipine HCl
20-abx076668	Abbexa	EUR 360.00 EUR 276.00	250 mg 50 mg

Hinokitiol
20-abx076673	Abbexa	EUR 510.00 EUR 292.80	250 mg 50 mg

SAHA (Vorinostat)
20-abx076681	Abbexa	EUR 627.60 EUR 309.60	250 mg 50 mg

CAPE
20-abx076682	Abbexa	EUR 627.60 EUR 309.60	250 mg 50 mg

Amlodipine
20-abx076693	Abbexa	EUR 444.00 EUR 309.60	250 mg 50 mg

Ambroxol HCl
20-abx076696	Abbexa	EUR 376.80 EUR 309.60	500 mg 50 mg

Gefitinib
20-abx076698	Abbexa	EUR 577.20 EUR 309.60	250 mg 50 mg

Ro 20-1724
20-abx076704	Abbexa	EUR 526.80 EUR 309.60	250 mg 50 mg

Edaravone
20-abx076734	Abbexa	EUR 744.00 EUR 343.20	250 mg 50 mg

Nitrendipine
20-abx076743	Abbexa	EUR 828.00 EUR 343.20	250 mg 50 mg

WY-14643
20-abx076749	Abbexa	EUR 777.60 EUR 360.00	250 mg 50 mg

Irinotecan HCl
20-abx076771	Abbexa	EUR 861.60 EUR 376.80	250 mg 50 mg

Simvastatin
20-abx076772	Abbexa	EUR 927.60 EUR 376.80	250 mg 50 mg

Montelukast sodium
20-abx076787	Abbexa	EUR 460.80 EUR 410.40	250 mg 50 mg

Pinacidil Monohydrate
20-abx076841	Abbexa	EUR 243.60 EUR 309.60	10 mg 50 mg

Mycophenolate mofetil
20-abx076846	Abbexa	EUR 594.00 EUR 292.80	250 mg 50 mg

Genistein
20-abx076504	Abbexa	EUR 260.40 EUR 360.00	10 mg 50 mg

Difluoromethylornithine
20-abx076505	Abbexa	EUR 243.60 EUR 376.80	10 mg 50 mg

AICAR
20-abx076506	Abbexa	EUR 292.80 EUR 376.80	10 mg 50 mg

Ebselen
20-abx076507	Abbexa	EUR 276.00 EUR 393.60	10 mg 50 mg

Apigenin
20-abx076511	Abbexa	EUR 260.40 EUR 444.00	10 mg 50 mg

Valinomycin
20-abx076516	Abbexa	EUR 276.00 EUR 460.80	10 mg 50 mg

HPA
20-abx076517	Abbexa	EUR 309.60 EUR 460.80	10 mg 50 mg

Anisomycin
20-abx076518	Abbexa	EUR 260.40 EUR 460.80	10 mg 50 mg

Pifithrin mu
20-abx076519	Abbexa	EUR 276.00 EUR 460.80	10 mg 50 mg

Carnosic acid
20-abx076520	Abbexa	EUR 292.80 EUR 477.60	10 mg 50 mg

Lovastatin
20-abx076523	Abbexa	EUR 276.00 EUR 510.00	10 mg 50 mg

Miglitol
20-abx076525	Abbexa	EUR 309.60 EUR 526.80	10 mg 50 mg

Necrostatin
20-abx076526	Abbexa	EUR 326.40 EUR 543.60	10 mg 50 mg

Zerumbone
20-abx076528	Abbexa	EUR 276.00 EUR 543.60	10 mg 50 mg

Rosiglitazone Maleate
20-abx076529	Abbexa	EUR 292.80 EUR 543.60	10 mg 50 mg

Tranilast
20-abx076530	Abbexa	EUR 292.80 EUR 543.60	10 mg 50 mg

Teprenone
20-abx076531	Abbexa	EUR 309.60 EUR 543.60	10 mg 50 mg

Duloxetine HCl
20-abx076532	Abbexa	EUR 292.80 EUR 543.60	10 mg 50 mg

Sorafenib
20-abx076534	Abbexa	EUR 292.80 EUR 560.40	10 mg 50 mg

Vandetanib
20-abx076535	Abbexa	EUR 292.80 EUR 560.40	10 mg 50 mg

Betulinic Acid
20-abx076536	Abbexa	EUR 292.80 EUR 560.40	10 mg 50 mg

Felodipine
20-abx076537	Abbexa	EUR 309.60 EUR 560.40	10 mg 50 mg

FK506
20-abx076538	Abbexa	EUR 360.00 EUR 577.20	10 mg 50 mg

TOFA
20-abx076541	Abbexa	EUR 309.60 EUR 594.00	10 mg 50 mg

Lenalidomide
20-abx076543	Abbexa	EUR 326.40 EUR 594.00	10 mg 50 mg

Vatalanib Dihydrochloride
20-abx076544	Abbexa	EUR 309.60 EUR 594.00	10 mg 50 mg

Dimethyloxaloylglycine (DMOG)
20-abx076547	Abbexa	EUR 309.60 EUR 610.80	10 mg 50 mg

Astemizole
20-abx076549	Abbexa	EUR 309.60 EUR 627.60	10 mg 50 mg

Decitabine
20-abx076551	Abbexa	EUR 360.00 EUR 644.40	10 mg 50 mg

Tolcapone
20-abx076552	Abbexa	EUR 326.40 EUR 644.40	10 mg 50 mg

Amifostine
20-abx076553	Abbexa	EUR 309.60 EUR 644.40	10 mg 50 mg

Lapatinib
20-abx076556	Abbexa	EUR 309.60 EUR 644.40	10 mg 50 mg

D-LAP5
20-abx076557	Abbexa	EUR 309.60 EUR 661.20	10 mg 50 mg

D-LAP5.Na
20-abx076558	Abbexa	EUR 309.60 EUR 661.20	10 mg 50 mg

C2 Ceramide
20-abx076559	Abbexa	EUR 343.20 EUR 678.00	10 mg 50 mg

(R, S)-Niguldipine HCl
20-abx076561	Abbexa	EUR 326.40 EUR 693.60	10 mg 50 mg

BCTC
20-abx076566	Abbexa	EUR 427.20 EUR 693.60	10 mg 50 mg

Isradipine
20-abx076567	Abbexa	EUR 326.40 EUR 693.60	10 mg 50 mg

BRL-50481
20-abx076568	Abbexa	EUR 326.40 EUR 693.60	10 mg 50 mg

SP600125
20-abx076569	Abbexa	EUR 309.60 EUR 693.60	10 mg 50 mg

Rottlerin
20-abx076570	Abbexa	EUR 326.40 EUR 693.60	10 mg 50 mg

FCCP
20-abx076572	Abbexa	EUR 326.40 EUR 710.40	10 mg 50 mg

WHI P131
20-abx076573	Abbexa	EUR 326.40 EUR 710.40	10 mg 50 mg

HC-030031
20-abx076575	Abbexa	EUR 326.40 EUR 710.40	10 mg 50 mg

A-803467
20-abx076576	Abbexa	EUR 326.40 EUR 710.40	10 mg 50 mg

Rolipram
20-abx076577	Abbexa	EUR 326.40 EUR 710.40	10 mg 50 mg

Hydroxychloroquine
20-abx076578	Abbexa	EUR 326.40 EUR 727.20	10 mg 50 mg

AS 041164
20-abx076579	Abbexa	EUR 326.40 EUR 727.20	10 mg 50 mg

SC 514
20-abx076580	Abbexa	EUR 326.40 EUR 727.20	10 mg 50 mg

BSI 201
20-abx076581	Abbexa	EUR 326.40 EUR 727.20	10 mg 50 mg

AG 494
20-abx076583	Abbexa	EUR 326.40 EUR 727.20	10 mg 50 mg

IU1
20-abx076584	Abbexa	EUR 343.20 EUR 744.00	10 mg 50 mg

Veratridine
20-abx076585	Abbexa	EUR 326.40 EUR 744.00	10 mg 50 mg

Nocodazole
20-abx076586	Abbexa	EUR 343.20 EUR 744.00	10 mg 50 mg

STF-62247
20-abx076587	Abbexa	EUR 343.20 EUR 760.80	10 mg 50 mg

BAY 11 7082
20-abx076588	Abbexa	EUR 343.20 EUR 777.60	10 mg 50 mg

ML297
20-abx076589	Abbexa	EUR 326.40 EUR 777.60	10 mg 50 mg

Sulindac Sulfide
20-abx076592	Abbexa	EUR 360.00 EUR 794.40	10 mg 50 mg

Sulindac Sulfone
20-abx076593	Abbexa	EUR 376.80 EUR 794.40	10 mg 50 mg

Antibiotic A-23187
20-abx076596	Abbexa	EUR 360.00 EUR 794.40	10 mg 50 mg

Z-Asp-CH2-DCB
20-abx076598	Abbexa	EUR 360.00 EUR 844.80	10 mg 50 mg

Taxol
20-abx076600	Abbexa	EUR 360.00 EUR 844.80	10 mg 50 mg

AP-18
20-abx076607	Abbexa	EUR 360.00 EUR 861.60	10 mg 50 mg

TCID
20-abx076608	Abbexa	EUR 360.00 EUR 861.60	10 mg 50 mg

1-Deoxynojirimycin
20-abx076609	Abbexa	EUR 393.60 EUR 861.60	10 mg 50 mg

Docetaxel
20-abx076610	Abbexa	EUR 360.00 EUR 878.40	10 mg 50 mg

A-967079
20-abx076611	Abbexa	EUR 376.80 EUR 878.40	10 mg 50 mg

Flupirtine maleate
20-abx076612	Abbexa	EUR 376.80 EUR 878.40	10 mg 50 mg

Troglitazone
20-abx076613	Abbexa	EUR 360.00 EUR 895.20	10 mg 50 mg

Dofetilide
20-abx076614	Abbexa	EUR 376.80 EUR 895.20	10 mg 50 mg

Bromfenac sodium
20-abx182389	Abbexa	EUR 510.00 EUR 427.20	1 g 50 mg

Cabozantinib, XL184
20-abx182391	Abbexa	EUR 577.20 EUR 477.60	100 mg 50 mg

D-23129,Ezogabine,N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamicacidethylester
20-abx182411	Abbexa	EUR 861.60 EUR 610.80	1 g 50 mg

Dabrafenib
20-abx182412	Abbexa	EUR 1095.60 EUR 794.40	100 mg 50 mg

Diazoxide
20-abx182416	Abbexa	EUR 393.60 EUR 343.20	100 mg 50 mg

Ingenol
20-abx182495	Abbexa	EUR 1963.20 EUR 610.80	50 mg 5 mg

Ly2157299
20-abx182508	Abbexa	EUR 577.20 EUR 1296.00	10 mg 50 mg

Ly2835219
20-abx182509	Abbexa	EUR 2013.60 EUR 811.20	250 mg 50 mg

Prucalopride
20-abx182627	Abbexa	EUR 343.20 EUR 594.00	10 mg 50 mg

Terlipressin Peptide
20-abx260093	Abbexa	EUR 1212.00 EUR 627.60	250 mg 50 mg

Cow Apo Transferrin Protein
20-abx263098	Abbexa	EUR 393.60 EUR 276.00	150 mg 50 mg

Atosiban Peptide
20-abx263519	Abbexa	EUR 276.00 EUR 410.40	10 mg 50 mg

Co-1686
20-abx183952	Abbexa	EUR 427.20 EUR 627.60	10 mg 50 mg

Enzastaurin
20-abx184026	Abbexa	EUR 343.20 EUR 644.40	10 mg 50 mg

Iloperidone
20-abx184123	Abbexa	EUR 326.40 EUR 594.00	10 mg 50 mg

Ly411575
20-abx184164	Abbexa	EUR 727.20 EUR 1813.20	10 mg 50 mg

Mpep
20-abx184236	Abbexa	EUR 376.80 EUR 878.40	10 mg 50 mg

N-[2-[4-(2-Methoxyphenyl)-1-Piperazinyl]Ethyl]-N-2-Pyridinyl-Cyclohexanecarboxamide Maleate
20-abx184252	Abbexa	EUR 526.80 EUR 1161.60	10 mg 50 mg

Sd-208
20-abx184357	Abbexa	EUR 526.80 EUR 1528.80	10 mg 50 mg

Stf-62247
20-abx184379	Abbexa	EUR 360.00 EUR 727.20	10 mg 50 mg

Tideglusib
20-abx184443	Abbexa	EUR 360.00 EUR 610.80	10 mg 50 mg

Upf 1069
20-abx184469	Abbexa	EUR 427.20 EUR 994.80	10 mg 50 mg

Vu 0364439
20-abx184478	Abbexa	EUR 460.80 EUR 1228.80	10 mg 50 mg

2-(1,3-dimethyl-2,6-dioxopurin-7-yl)-N-(4-propan-2-ylphenyl)acetamide
20-abx184531	Abbexa	EUR 410.40 EUR 828.00	10 mg 50 mg

Ibrutinib
20-abx184706	Abbexa	EUR 1078.80 EUR 710.40	100 mg 50 mg

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.