cardiac remodeling after myocardial infarction (MI) is a maladaptive changes associated with progressive heart failure and compromise the long-term clinical outcomes. Most of the patients afflicted by MI still developing adverse outcomes associated with cardiac remodeling. Therefore, it is important to identify biomarkers for early prediction of cardiac remodeling. An in-depth proteomic approaches, including both an array of semi-quantitative and quantitative antibody, is used to identify circulating biomarkers that may be associated with adverse cardiac remodeling.

Furthermore, the statistical correlation analysis was conducted between biomarker candidates and clinical cardiac remodeling the data to demonstrate their clinical utility. A proteomics systematic approach revealed that sclerostin (SOST), differentiation of growth factor-15 (GDF-15), urokinase-type plasminogen activator (uPA) and midkine (MK) increases, while monocytes chemotactic protein – 3 (MCP- 3 ) is a unique decreased in patients who develop cardiac remodeling MI, compared with patients with MI not develop cardiac remodeling and healthy humen.

In addition, the analysis of the correlation between the proteomes of serum and cardiac remodeling parameters of echocardiography showed a positive relationship moderate between left ventricular indexes end-diastolic volume (LVEDVi) and three serum protein , uPA, MK and GDF-15 (P <0 , 05, respectively), and moderate negative correlation between LV ejection fraction (LVEF) and serum is protein (P <0.05, respectively). Importantly, uPA and MK were first identified associated with the development of cardiac remodeling. The research contributes to a better understanding of various cytokines expressed during adverse cardiac remodeling. biomarkers identified could facilitate the early identification of patients at high risk for ischemic heart failure awaiting further confirmation through larger clinical trials.

Prevention of severe intestinal dysfunction Through Barrier Single-Species Probiotic Is Associated With Microbiome-Mediated Activation of Glutamate-Glutamine Biosynthesis Introduction: Intra-abdominal hypertension (IAH), the leading complications in the intensive care unit, significantly disrupt the intestinal microbial composition by reducing the relative abundance of Lactobacillus and increasing the relative abundance of opportunistic infectious bacteria.

In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis
In-depth proteomics approach reveals novel biomarkers of cardiac remodelling after myocardial infarction: An exploratory analysis


Method: In order to evaluate the preventive effect of probiotic-based Lactobacillus at IAH-induced damage intestinal barrier, a-single species of probiotics (L92) and multi-species probiotics (VSL # 3 ) is introduced orally to rats Sprague-Dawley 7 days before inducing IAH. Histology intestine and permeability to macromolecules (isothiocyanate fluoresceine, FITC-dextran, N = 8 for each group), parameter immunomodulatory and response to oxidative [ monocytes chemotactic protein 1 (MCP-1), interleukin-1β (IL-1β), interleukin-4 (IL-4), interleukin-10 (IL-10), malonaldehyde (MDA), glutathione peroxidase (GSH- Px), catalase (CAT) and superoxide dismutase (SOD); N = 4 for each group], and profiling microbiome (N = 4 per group) were analyzed.

(S)-MCPG

B6266-5 5 mg
EUR 139.2

(RS)-MCPG

HY-100371 100mg
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(S)-MCPG

HY-100406 5mg
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(RS)-MCPG disodium salt

B7476-10 10 mg
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(RS)-MCPG disodium salt

B7476-50 50 mg
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L-NMMA: (50mg)

00224 25MG
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Gentamicin, 50mg/ml

CA003-001 10ml
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90083 50MG
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50mg Blasticidin S HCl

30-100-RB EACH
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Kanamycin solution (50mg/ml)

MN800A-1 20 ml
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60014 50MG
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Cy3 Bis Nhs Ester 50Mg

PA13002 EACH
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YCW152102 EACH
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C18(EC) 50mg/1mL SPE Columns

CHR5622 PK100
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Goat Anti-Mouse IgG Fc, 50MG

A008-50MG 50MG
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Goat Anti-Rabbit IgG Fc, 50MG

A009-50MG 50MG
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C18(EC) 50mg Fixed-well Plate

CHR5624 EACH
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Standard Nitrile 50mg/L as N

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Caffeine Standard 50mg/L in Water

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Peracetic Acid Indicator Strips 0-50mg/L

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Kinesis TELOS QuEChERS Clean-up Kit Dispersive Pigmented Fruit and Veg; AOAC 2007.01; 150mg MgSO4 50mg PSA 50mg PestiCarb; 2ml

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Recombinant Bovine ATF Protein, Untagged, -50mg

QP11095-50mg 50mg
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Alkalinity Std 50mg/L 50ppm as CaCO3

TA0501 1L
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ICAA04 500ML
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Spectropho Pot Dichro A/T Std 50mg/L in Cuvs

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ICP12-50-100 100ML
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Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; AOAC 2007.01; 150mg MgSO4 and 50mg PSA;2ml

CHR6478 PK100
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TA10M5 500ML
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TA4M05 500ML
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semi balance 60/120mg 0.01/0.1mg

BAL1164 EACH
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Pot Dichro A/T Std 80mg/L w/ 0.005M Sulph Acid in Cuv

RSPEC-EP00880 EACH
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Pot Dichro A/T Std 600mg/L w/ 0.005M Sulph Acid 2x Blanks in Cuvs

RSPEC-EP0061X2BU PK3
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RSPEC-EP0100X2BU PK3
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TA1001 1L
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TA2501 1L
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Absorb Std Pot Dichro 60mg/L w/ 0.005M Sulph Acid in Cuvs

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Pot Dichro A/T Std 60mg/L w/ 0.005M Sulph Acid 2x Blanks in Cuvs

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TDS2000 1L
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59002 100MG
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C18 500mg/10mL

CHR5610 PK20
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59003 100MG
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SCAS: (100mg)

70037 100MG
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TDS Std 100mg/L

TDS100 1L
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TDS Std 250mg/L

TDS250 1L
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Water-soluble Cumate solution (300mg/ml, 10,000x), 500ul

QM150A-1 500 ul
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COD test 150-1000mg per L

LCK114 PK25
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COD Test 15-150mg per L

WAT3624 1KIT
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COD Test 50-300mg per L

WAT3626 1KIT
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COD Test 100-2000mg per L

WAT3628 EACH
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COD Test Kit 25 to 1500mg/L

WAT4314 PK25
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COD Test Kit 500 to 10000mg/L

WAT4316 PK25
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DiOC6(3): (100mg)

70009 100MG
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MTSES: (100mg)

91020 100MG
EUR 154.8
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MTSET: (100mg)

91021 100MG
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Description: Minimum order quantity: 1 unit of 100MG

MTSEA: (100mg)

91022 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSEH: (100mg)

91023 100MG
EUR 310.8
Description: Minimum order quantity: 1 unit of 100MG

MTSPA: (100mg)

91024 100MG
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Description: Minimum order quantity: 1 unit of 100MG

MTSPS: (100mg)

91025 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

MTSBS: (100mg)

91026 100MG
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Description: Minimum order quantity: 1 unit of 100MG

MTSPT: (100mg)

91027 100MG
EUR 154.8
Description: Minimum order quantity: 1 unit of 100MG

Rnase A, 250mg

R9001-250mg each
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AEAETS:100mg

91031 100MG
EUR 204
Description: Minimum order quantity: 1 unit of 100MG

COD Test Kit 10 to 150mg/L

WAT4312 PK25
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Ammonium Standard 1mg/L 500mL

189149 EACH
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TOC/TIC Mixed Std 30mg/L Org 8mg/L Inorg Carb

TOIC308 500ML
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AAS Zinc Std 5000mg/L in 2-5% HNO3

AAZN505 500ML
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Nitrate Std 1000mg/L as N

SDN01000 500ML
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Nitrate Std 1000mg/L as N

SDN010001 1L
EUR 182.4

COD MR 0 to 1500mg/L reagent

WAT1032 EACH
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COD HR 0 to 15000mg/L reagent

WAT1034 EACH
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E62C01601 100ug
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Low range cod vial 3-150mg

21258-51 PK25
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Chloride Std 2200mg/L

CL22001 1L
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Chloride Std 10000mg/L as Cl

CLHY10M5 500ML
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COD Vials 13 mm Hg free 0-1000mg per l

LCK214 PK25
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ICP Multi Elem (9) Std 1000mg/L

ICPMIX-9-100 100ML
EUR 279.4

Biotin-XX, SE: (100mg)

90052 100MG
EUR 290.4
Description: Minimum order quantity: 1 unit of 100MG

BD ecgs bovine 100mg

356006 EACH
EUR 528

C8(EC) 100mg/1mL SPE Colum

CHR5654 PK100
EUR 213.6

Nitrate Std 100mg/L as N

SDN01001 1L
EUR 212.81

Nitrate Std 500mg/L as N

SDN05005 500ML
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Nitrate Std 200mg/L as N

SDNO2001 1L
EUR 330

COD LR 0 to 150mg/L reagent

WAT1030 EACH
EUR 84

High Range Cod Vial 20-1500mg

21259-51 PK25
EUR 116.4

Zinc Sulphate 1000mg/L

ZN10001 1L
EUR 229.79

M Butyricum 100Mg

264010 PK6
EUR 261.12

Chloride Std 220mg/L

CL2201 1L
EUR 270

COD STandard 800mg/l

PL474 EACH
EUR 25.2

Rapamycin, 100mg

R5312-100mg each
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Chloride Std 200mgL 100ml

CHL2030 EACH
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IC Anion Std Silica 2000mg/L in H2O

ICAC12 500ML
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ICP Multi Elem (11) Std in 3.5% HNO3 + 0.5% HF 1000mg/L

ICP-MIX-CYM12 250ML
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ICP Multi Elem (10) Std in 2% HNO3 1000mg/L

ICP10-1000-100 100ML
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ICP Multi Elem (11) Std in 5% HNO3 1000mg/L

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ICP Multi Elem (11) Std in 2% HNO3 1000mg/L

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ICP Multi Elem (6) Std USP 232/233 10mg/L in 15% HCL

REICPUSPIV 100ML
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Ammonium Test 0.015-2mg per L NH

WAT3602 1KIT
EUR 181.44

Ammonium Test 47-130mg per L NH

WAT3608 1KIT
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Sulphate Test 40-150mg per L

WAT3642 EACH
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Organic Acid Test 50 to 3000mg/L

WAT4326 PK25
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NH2 100mg/1mL SPE Columns

CHR5528 PK100
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NH2 200mg/3mL SPE Columns

CHR5530 PK50
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CHR5532 PK50
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NH2 500mg/6mL SPE Columns

CHR5534 PK30
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C18 100mg/1mL SPE Columns

CHR5586 PK100
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CHR5596 PK50
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C18 500mg/6mL SPE Columns

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C18(EC) 100mg/1mL SPE Columns

CHR5626 PK100
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CHR5636 PK50
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CHR5638 PK30
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SCX 200mg/3mL SPE Columns

CHR5692 PK50
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CHR5694 PK50
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CHR5828 PK50
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CHR5832 PK30
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ICP Multi Elem (3) Std B P S 100mg/L in H2O

ICP-INT-3-500 500ML
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ICP Multi Elem (3) Std in 2% HCl Hg Ca Mg 100mg/L

ICP-MET-3-100 100ML
EUR 151.45

Nitrate Test Kit 23 to 225mg/L

WAT4320 PK25
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Zinc Sulphate 220mg/L

ZN221 1L
EUR 160.59

5(6)TAMRA SE: (25mg)

90022 25MG
EUR 248.4
Description: Minimum order quantity: 1 unit of 25MG

IC Multi Elem (5) Anion Std 1000mg/L in H2O

ICA-AIT-5-100 100ML
EUR 394.29

Recombinant other Terlipressin Protein, Untagged, E.coli-50mg

QP13723-50mg 50mg
EUR 435.6

Recombinant other Urease Protein, Untagged, E.coli-50mg

QP10907-50mg 50mg
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Recombinant other Atosiban Protein, Untagged, E.coli-50mg

QP11102-50mg 50mg
EUR 261.6

Recombinant Bovine HTF Protein, Untagged, E.coli-50mg

QP12351-50mg 50mg
EUR 186

Recombinant E.coli LACTB Protein, Untagged, E.coli-50mg

QP12522-50mg 50mg
EUR 4386

Recombinant Human CTRB1 Protein, Untagged, E.coli-50mg

QP10565-50mg 50mg
EUR 675.6

Recombinant Yeast IDH1 Protein, Untagged, Yeast-50mg

QP10670-50mg 50mg
EUR 1251.6

Recombinant other Exenatide Protein, Untagged, E.coli-50mg

QP11816-50mg 50mg
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Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; EN 15662; 150mg MgSO4 and 25mg PSA; 2ml

CHR6480 PK100
EUR 168

M Tuberculh37 100Mg

231141 PK6
EUR 336.84

Biotin-X, free acid:100mg

90053 100MG
EUR 158.4
Description: Minimum order quantity: 1 unit of 100MG

Bioin-XX, free acid: (100mg)

90054 100MG
EUR 258
Description: Minimum order quantity: 1 unit of 100MG

neo PRP 150mg/6mL SPE Columns

CHR5756 PK30
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CHR5760 PK30
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neo PCX 200mg/6mL SPE Columns

CHR5780 PK30
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neo WCX 200mg/6mL SPE Columns

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neo WAX 100mg/3mL SPE Columns

CHR5824 PK50
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neo WAX 200mg/6mL SPE Columns

CHR5826 PK30
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POLY(I)POLY(C) 265MG STERILE

GE27-4732-01 EACH
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ICP Multi Elem (9) Std in 2% HNO3 100mg/L

ICP-MET-9-100 100ML
EUR 421.71

ICP Multi Elem (5) Std 100mg/L in 2% HNO3

ICP-MIX2 125ML
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ICP Multi Elem (12) Std in 2-5% HNO3 100mg/L

ICP12-100-100 100ML
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ICP Multi Elem (18) Std 100mg/L in 5% HNO3

ICPM002 125ML
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Cyclosporin A, 100mg

R5986-100mg each
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Nitrogen Total HR 10 to 150mg/l

WAT1070 EACH
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Ammonium Test 1-12mg per L NH

WAT3604 1KIT
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Ammonium Test 2-47mg per L NH

WAT3606 1KIT
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COD Standard 1000mg Per Litre

COD1000 500ML
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IC Anion Std Chloride 5000mg/L in H2O

ICAD02-5000 500ML
EUR 186.7

IC Anion Std Sulphate 10000mg/L in H2O

ICAD06 500ML
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IC Anion Std Fluoride 5000mg/L in H2O

ICAE03 500ML
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IC Anion Std Fluoride 10000mg/L in H2O

ICAS0310M 500ML
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Phosphorus Total HR 0-100mg/l

WAT1044 EACH
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DiBAC4(3): (25mg)

61011 25MG
EUR 216
Description: Minimum order quantity: 1 unit of 25MG

Goat Anti-Mouse IgG Fc, 100MG

A008-100MG 100MG
EUR 1528

Secura Balance 21g 0.002mg IC

BAL3872 EACH
EUR 27357.6

PSDVB 500mg/6mL SPE Columns

CHR5844 PK30
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IC Anion Std Nitrate 500mg/L in H2O

ICAA4105 500ML
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Phenol Solution 100mg/L

PNL010F 1L
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Doxorubicin HCl, 100mg

R2531-100mg each
EUR 1560

Ammonia HR 0 -100mg/l reagent

WAT1048 EACH
EUR 132

Phosphate Test 1.6-30mg per L

WAT3640 1KIT
EUR 138.43

CORNING® BOVINE PITUITARY EXTRACT (BPE), 75MG, 15MG/CONTAINER, 5/PACK

356123 1/pk
EUR 525.6
Description: Cell Culture Reagents; Growth Supplements - DL

3 5 Dichlorophenol 1000mg/L

DPC10001 1L
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Rat α1-MG ELISA Kit

ERAF0008 96Tests
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Rat α2-MG ELISA Kit

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Rat α1-MG ELISA Kit

ERM0008 96Tests
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Rat α2-MG ELISA Kit

ERM0009 96Tests
EUR 625.2

Rat β2-MG ELISA Kit

ERM0211 96Tests
EUR 625.2

Zinc Test 0.2-6mg per L

WAT3644 PK
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Calcium Standard 100mg/l

51344771 EACH
EUR 120

Goat Anti-Rabbit IgG Fc, 100MG

A009-100MG 100MG
EUR 1528

Results: 7 days pretreatments of L92 significantly reduced IAH-induced increase in intestinal permeability to FITC-dextran and histological damage (P <0.0001), accompanied by the suppression of inflammation and oxidative activation. Increased MCP-1 and IL-1β was significantly inhibited (P <0.05); anti-inflammatory cytokine, IL-4 and IL-10 were maintained at a high level; and oppression CAT (P <0.05) significantly reversed when pretreated with L92.