Monocyte chemotactic protein-1 and nitrotyrosine in irritable bowel syndrome
Irritable bowel syndrome (IBS) is one of the most frequent and common functional gastrointestinal disorder that has aetiopathogenesis multifactorial. Several biomarkers have been tested in the search for a reliable and specific biomarkers, but there is no specific biomarkers for IBS. The purpose of this study was to evaluate two different biomarkers putative pathways of pathogenesis of IBS: monocyte chemotactic protein-1 (MCP-1) and nitrotyrosine, in order to establish their role as potential biomarkers.
We enrolled 42 consecutive patients diagnosed with IBS by Rome III criteria and 35 healthy controls, respectively. serum concentration of two biomarkers (MCP-1 and nitrotyrosine) is determined by using a commercial ELISA kit. serum levels of MCP-1 were not statistically significantly higher in IBS patients than the control group (204 ± 130 vs 174 ± 73 pg / ml; P = 0.311). nitrotyrosine levels were statistically significantly lowered in IBS patients than the control group (30 ± 12 vs 353 ± 14 nM; P = 0.050).
MCP-1 levels were higher in patients with the metabolic syndrome compared IBS IBS patients without metabolic syndrome (239 ± 153 vs 168 ± 120 pg / ml; P = 0.948) and in control with the metabolic syndrome (174 ± 56 pg / ml). MCP-1 serum levels were statistically significantly higher in IBS patients with the metabolic syndrome compared with controls (239 ± 153 vs 157 ± 89 pg / ml; P = 0.037), showing several factors involved, especially diet and its association with metabolic syndrome, and it shows that MCP-1 coul
Evaluation of Immunomodulatory Ability of Lactic Acid Bacteria Isolated from Cattle Feedlot Against Mastitis Using Bovine Mammary Epithelial Cells In Vitro Assay
bovine mastitis, an inflammation of the mammary gland, affecting the quality and quantity of milk production. mastitis control relies on a combination of one or more antibiotic therapy. Because of the increasing antibiotic resistance in pathogens, intramammary infusion of lactic acid bacteria (LAB) has been considered as a potential alternative to antibiotics to treat and prevent bovine mastitis through the host immune enhancement. the effect of probiotic strain-dependent characteristics;
Therefore, strains of LAB candidate must be evaluated efficiently identify those with the best potential. Here, we examine the LAB strains were originally isolated from the environment fattening cattle on their ability to induce the Toll-like receptor (TLR) -triggered inflammatory response in bovine mammary epithelial (BME) cells in vitro.
BME cells were pre-stimulated with LAB strains individually for 12, 24, and 48 hours and then challenged with Escherichia coli -derived lipopolysaccharide (LPS) for 12 hours. MRNA expression of immune selected gene-interleukin 1 alpha ( IL-1α ), IL-1β , monocytes chemotactic protein 1 ( MCP-1 ), IL-8 , chemokine (CXC motif) ligand 2 ( CXCL2 ), and CXCL 3 as measured by real-time quantitative PCR (RT-qPCR). The results showed that pretreatment with few Lactobacillus strains capable of differentially regulate inflammatory responses in cell LPS BME;
(RS)-MCPG |
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| B6265-5 | ApexBio | 5 mg | EUR 91.2 |
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Description: Neuroscience|GluR |
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(RS)-MCPG |
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| B6265-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 250.8 |
(RS)-MCPG |
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| B6265-50 | ApexBio | 50 mg | EUR 489.6 |
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Description: Neuroscience|GluR |
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(S)-MCPG |
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| B6266-10 | ApexBio | 10 mg | EUR 145.6 |
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Description: Neuroscience|GluR |
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(S)-MCPG |
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| B6266-25 | ApexBio | 25 mg | EUR 304 |
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Description: Neuroscience|GluR |
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(S)-MCPG |
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| B6266-5 | ApexBio | 5 mg | EUR 105.6 |
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Description: Neuroscience|GluR |
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(S)-MCPG |
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| B6266-50 | ApexBio | 50mg | EUR 523.2 |
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Description: Neuroscience|GluR |
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(RS)-MCPG |
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| HY-100371 | MedChemExpress | 100mg | EUR 465.38 |
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Description: (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2]. |
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(S)-MCPG |
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| HY-100406 | MedChemExpress | 5mg | EUR 471.87 |
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Description: (S)-MCPG ((+)-MCPG) is a potent group I/II metabotropic glutamate receptor (mGluRs) antagonist and the active isomer of (RS)-MCPG (HY-100371)[1]. (S)-MCPG can be used for the study of the function of mGluRs in spatial learning[2]. |
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(S)-MCPG |
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| M199718 | Toronto Research Chemicals | 1g | EUR 7600 |
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Description: 150145-89-4 |
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(RS)-MCPG |
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| M264743 | Toronto Research Chemicals | 100mg | EUR 3000 |
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Description: 146669-29-6 |
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(RS)-MCPG |
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| MBS579609-10mg | MyBiosource | 10mg | EUR 180 |
(RS)-MCPG |
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| MBS579609-25mg | MyBiosource | 25mg | EUR 275 |
(RS)-MCPG |
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| MBS579609-2mg | MyBiosource | 2mg | EUR 145 |
(RS)-MCPG |
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| MBS579609-50mg | MyBiosource | 50mg | EUR 410 |
(RS)-MCPG |
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| MBS579609-5mg | MyBiosource | 5mg | EUR 160 |
(S)-MCPG |
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| MBS5754201-200mg | MyBiosource | 200mg | EUR 1055 |
(S)-MCPG |
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| MBS5754201-5x200mg | MyBiosource | 5x200mg | EUR 4610 |
(RS)-MCPG |
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| MBS3607307-10mg | MyBiosource | 10mg | EUR 245 |
(RS)-MCPG |
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| MBS3607307-25mg | MyBiosource | 25mg | EUR 340 |
(RS)-MCPG |
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| MBS3607307-2mg | MyBiosource | 2mg | EUR 200 |
(RS)-MCPG |
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| MBS3607307-50mg | MyBiosource | 50mg | EUR 475 |
(RS)-MCPG |
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| MBS3607307-5mg | MyBiosource | 5mg | EUR 220 |
(RS)-MCPG |
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| MBS3845259-100mg | MyBiosource | 100mg | EUR 910 |
(RS)-MCPG |
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| MBS3845259-10mg | MyBiosource | 10mg | EUR 210 |
(RS)-MCPG |
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| MBS3845259-50mg | MyBiosource | 50mg | EUR 485 |
(RS)-MCPG |
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| MBS3845259-5mg | MyBiosource | 5mg | EUR 165 |
(RS)-MCPG |
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| MBS3845259-5x100mg | MyBiosource | 5x100mg | EUR 4085 |
(S)-MCPG |
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| MBS3844992-100mg | MyBiosource | 100mg | EUR 825 |
(S)-MCPG |
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| MBS3844992-10mg | MyBiosource | 10mg | EUR 200 |
(S)-MCPG |
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| MBS3844992-50mg | MyBiosource | 50mg | EUR 440 |
(S)-MCPG |
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| MBS3844992-5mg | MyBiosource | 5mg | EUR 155 |
(S)-MCPG |
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| MBS3844992-5x100mg | MyBiosource | 5x100mg | EUR 3695 |
(S)-MCPG |
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| T13452-10mg | TargetMol Chemicals | 10mg | Ask for price |
|
Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-1g | TargetMol Chemicals | 1g | Ask for price |
|
Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-1mg | TargetMol Chemicals | 1mg | Ask for price |
|
Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-50mg | TargetMol Chemicals | 50mg | Ask for price |
|
Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-5mg | TargetMol Chemicals | 5mg | Ask for price |
|
Description: (S)-MCPG |
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(RS)-MCPG |
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| T3479-10mg | TargetMol Chemicals | 10mg | Ask for price |
|
Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-1g | TargetMol Chemicals | 1g | Ask for price |
|
Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-1mg | TargetMol Chemicals | 1mg | Ask for price |
|
Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-50mg | TargetMol Chemicals | 50mg | Ask for price |
|
Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-5mg | TargetMol Chemicals | 5mg | Ask for price |
|
Description: (RS)-MCPG |
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MCPG (sodium) |
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| HY-103570 | MedChemExpress | Get quote | Ask for price |
|
Description: MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) [1]. |
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(RS)-MCPG disodium salt |
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| B7476-10 | ApexBio | 10 mg | EUR 126.4 |
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Description: Neuroscience|GluR |
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(RS)-MCPG disodium salt |
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| B7476-100 | ApexBio | 100mg | EUR 900 |
|
Description: Neuroscience|GluR |
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(RS)-MCPG disodium salt |
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| B7476-25 | ApexBio | 25mg | EUR 278.4 |
|
Description: Neuroscience|GluR |
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(RS)-MCPG disodium salt |
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| B7476-5 | ApexBio | 5mg | EUR 91.2 |
|
Description: Neuroscience|GluR |
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(RS)-MCPG disodium salt |
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| B7476-50 | ApexBio | 50 mg | EUR 489.6 |
|
Description: Neuroscience|GluR |
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(RS)-MCPG disodium salt |
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| MBS5757736-50mg | MyBiosource | 50mg | EUR 1140 |
(RS)-MCPG disodium salt |
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| MBS5757736-5x50mg | MyBiosource | 5x50mg | EUR 4970 |
(RS)-MCPG disodium salt |
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| T23270-10mg | TargetMol Chemicals | 10mg | Ask for price |
|
Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-1g | TargetMol Chemicals | 1g | Ask for price |
|
Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-1mg | TargetMol Chemicals | 1mg | Ask for price |
|
Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-50mg | TargetMol Chemicals | 50mg | Ask for price |
|
Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-5mg | TargetMol Chemicals | 5mg | Ask for price |
|
Description: (RS)-MCPG disodium salt |
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Z-FR-AMC 25mg |
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| 10201 | Biotium | 25MG | EUR 167 |
|
Description: N/A |
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Z-FR-AMC 25mg |
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| 10201-1 | Biotium | EA | EUR 167 |
Cy 5 Maleimide 25Mg - EACH |
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| PA15136 | Scientific Laboratory Supplies | EACH | EUR 5432.4 |
Amersham Cy5.5 Maleimide 25mg - EACH |
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| PA15636 | Scientific Laboratory Supplies | EACH | EUR 4468.5 |
Deoxyribonuclease I (DNase I), 25mg |
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| PC0704-25mg | Vivantis | each | Ask for price |
Klebsiella Selective Supplement (25mg/vl) |
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| 29760 | Sisco Laboratories | 5 vl | EUR 10.26 |
|
Description: Part D |
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Goat Anti-Mouse IgG Fc, 25MG |
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| A008-25MG | Arbor Assays | 25MG | EUR 552.63 |
Goat Anti-Rabbit IgG Fc, 25MG |
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| A009-25MG | Arbor Assays | 25MG | EUR 552.63 |
Amersham CY3B NHS Ester 25MG - EACH |
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| PA63106 | Scientific Laboratory Supplies | EACH | EUR 6322.05 |
Chloramphenicol Solution, 25mg/mL in Methanol |
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| 40120754-1 | Bio-WORLD | 25 tube(s) | EUR 97.65 |
Chloramphenicol Solution, 25mg/mL in Methanol |
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| 40120754-2 | Bio-WORLD | 50 tube(s) | EUR 178.44 |
Streptomycin Sulfate Solution, 25mg/mL, Sterile |
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| 41910008-1 | Bio-WORLD | 50 mL | EUR 53.42 |
Donkey Anti-Sheep IgG (H&L), 25MG |
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| A010-25MG | Arbor Assays | 25MG | EUR 552.63 |
Amersham Cy3 Mono NHS ester 25mg - EACH |
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| PA13106 | Scientific Laboratory Supplies | EACH | EUR 4062.15 |
Amersham Cy5 mono NHS ester 25mg - EACH |
|||
| PA15106 | Scientific Laboratory Supplies | EACH | EUR 5108.4 |
Amersham Cy5.5 mono NHS ester 25mg - EACH |
|||
| PA15606 | Scientific Laboratory Supplies | EACH | EUR 4468.5 |
Caffeine Standard 25mg/L in Water - 5ML |
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| CAFSTD25005 | Scientific Laboratory Supplies | 5ML | EUR 275.4 |
OOMC00021-25MG - Carfilzomib |
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| OOMC00021-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOMC00024-25MG - JQ1 (+) |
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| OOMC00024-25MG | Aviva Systems Biology | 25mg | EUR 339 |
OOMC00027-25MG - Ascomycin |
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| OOMC00027-25MG | Aviva Systems Biology | 25mg | EUR 169 |
OOMC00031-25MG - Dasatinib |
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| OOMC00031-25MG | Aviva Systems Biology | 25mg | EUR 139 |
OOMC00032-25MG - Everolimus |
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| OOMC00032-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00059-25MG - Baricitinib |
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| OOMC00059-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00062-25MG - Pridopidine |
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| OOMC00062-25MG | Aviva Systems Biology | 25mg | EUR 429 |
OOMC00063-25MG - Selinexor |
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| OOMC00063-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOMC00064-25MG - Bromosporine |
|||
| OOMC00064-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00068-25MG - S1RA |
|||
| OOMC00068-25MG | Aviva Systems Biology | 25mg | EUR 399 |
OOMC00069-25MG - Siramesine |
|||
| OOMC00069-25MG | Aviva Systems Biology | 25mg | EUR 329 |
OOMC00070-25MG - PRE084 |
|||
| OOMC00070-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OOMC00073-25MG - SA4503 |
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| OOMC00073-25MG | Aviva Systems Biology | 25mg | EUR 299 |
OOMC00077-25MG - Ruxolitinib |
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| OOMC00077-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00084-25MG - Acalabrutinib |
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| OOMC00084-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00085-25MG - Volasertib |
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| OOMC00085-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00086-25MG - Favipiravir |
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| OOMC00086-25MG | Aviva Systems Biology | 25mg | EUR 219 |
OOMC00087-25MG - Ponatinib |
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| OOMC00087-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OOMC00089-25MG - Boceprvir |
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| OOMC00089-25MG | Aviva Systems Biology | 25mg | EUR 329 |
OOAU00079-25MG - Piceatannol |
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| OOAU00079-25MG | Aviva Systems Biology | 25mg | EUR 289 |
OOAU00086-25MG - Sirtinol |
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| OOAU00086-25MG | Aviva Systems Biology | 25mg | EUR 479 |
OOAU00087-25MG - Garcinol |
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| OOAU00087-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOAU00092-25MG - IOX1 |
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| OOAU00092-25MG | Aviva Systems Biology | 25mg | EUR 579 |
OOAU00094-25MG - DMXAA |
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| OOAU00094-25MG | Aviva Systems Biology | 25mg | EUR 669 |
IC Multi Elem (7) Anion Std 25mg/L in H2O - 250ML |
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| IC-MIX1 | Scientific Laboratory Supplies | 250ML | EUR 279.07 |
ATPγS, 25mg * Shipped on DRY ICE must be shipped Overnight * |
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| M-NU-406-25 | MiTeGen | - | EUR 400 |
|
Description: ATPγS, 25mg * Shipped on DRY ICE must be shipped Overnight * |
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OOMC00019-25MG - A77 1726 |
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| OOMC00019-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00022-25MG - RVX-208 |
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| OOMC00022-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00023-25MG - Dabrafenib (GSK2118436) |
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| OOMC00023-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00035-25MG - H89 - 2HCl |
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| OOMC00035-25MG | Aviva Systems Biology | 25mg | EUR 429 |
OOMC00036-25MG - PD-325901 |
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| OOMC00036-25MG | Aviva Systems Biology | 25mg | EUR 259 |
OOMC00057-25MG - INK-128 |
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| OOMC00057-25MG | Aviva Systems Biology | 25mg | EUR 139 |
OOMC00058-25MG - Santacruzamate A |
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| OOMC00058-25MG | Aviva Systems Biology | 25mg | EUR 219 |
OOMC00061-25MG - N4-Hydroxycytidine |
|||
| OOMC00061-25MG | Aviva Systems Biology | 25mg | EUR 329 |
OOMC00065-25MG - BI-2536 |
|||
| OOMC00065-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00066-25MG - I-BET762 |
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| OOMC00066-25MG | Aviva Systems Biology | 25mg | EUR 399 |
OOMC00067-25MG - NE-100 |
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| OOMC00067-25MG | Aviva Systems Biology | 25mg | EUR 299 |
OOMC00072-25MG - BD1047 dihydrobromide |
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| OOMC00072-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOMC00082-25MG - Palbociclib (PD0332991) |
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| OOMC00082-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00083-25MG - MK-2206 |
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| OOMC00083-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OPPA00535-25MG - Insulin Protein |
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| OPPA00535-25MG | Aviva Systems Biology | 25mg | EUR 154 |
OOAU00073-25MG - BML-278 |
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| OOAU00073-25MG | Aviva Systems Biology | 25mg | EUR 389 |
OOAU00075-25MG - EX-527 |
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| OOAU00075-25MG | Aviva Systems Biology | 25mg | EUR 389 |
OOAU00083-25MG - BML-210 |
|||
| OOAU00083-25MG | Aviva Systems Biology | 25mg | EUR 479 |
OOAU00084-25MG - C-646 |
|||
| OOAU00084-25MG | Aviva Systems Biology | 25mg | EUR 579 |
OOAU00088-25MG - BIX-01294 |
|||
| OOAU00088-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OORA00210-25MG - DNA (Calf Thymus) |
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| OORA00210-25MG | Aviva Systems Biology | 25mg | EUR 179 |
OPSA10621-25MG - NATIVE UBIQUITIN Protein |
|||
| OPSA10621-25MG | Aviva Systems Biology | 25mg | EUR 449 |
OOAU00076-25MG - FK-866 HCl |
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| OOAU00076-25MG | Aviva Systems Biology | 25mg | EUR 539 |
Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; EN 15662; 150mg MgSO4 and 25mg PSA; 2ml - PK100 |
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| CHR6480 | Scientific Laboratory Supplies | PK100 | EUR 189 |
OASB02218-25MG - Human ZAP-70 Antibody |
|||
| OASB02218-25MG | Aviva Systems Biology | 25mg | EUR 99 |
OOMC00044-25MG - Miglustat HCl (N-Butyldeoxynojirimycin) |
|||
| OOMC00044-25MG | Aviva Systems Biology | 25mg | EUR 479 |
OOMC00078-25MG - 7-Cl-O-Nec1 |
|||
| OOMC00078-25MG | Aviva Systems Biology | 25mg | EUR 259 |
OOSA09676-25MG - HORSERADISH PEROXIDASE Accessory Reagent |
|||
| OOSA09676-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OPPA01009-25MG - TP 5 - Thymopentin Protein |
|||
| OPPA01009-25MG | Aviva Systems Biology | 25mg | EUR 70 |
OPSA10512-25MG - NATIVE Human FIBRINOGEN Protein |
|||
| OPSA10512-25MG | Aviva Systems Biology | 25mg | EUR 199 |
Recombinant other Antide Protein, Untagged, E.coli-25mg |
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| QP11028-25mg | EnQuireBio | 25mg | EUR 663.6 |
Recombinant Human OCT Protein, Untagged, E.coli-25mg |
|||
| QP12920-25mg | EnQuireBio | 25mg | EUR 1154.4 |
Recombinant Human OT Protein, Untagged, E.coli-25mg |
|||
| QP12937-25mg | EnQuireBio | 25mg | EUR 241.2 |
Recombinant other Pramlintide Protein, Untagged, E.coli-25mg |
|||
| QP13132-25mg | EnQuireBio | 25mg | EUR 675.6 |
Recombinant Human Secretin Protein, Untagged, E.coli-25mg |
|||
| QP13449-25mg | EnQuireBio | 25mg | EUR 544.8 |
Recombinant other Sincalide Protein, Untagged, E.coli-25mg |
|||
| QP13506-25mg | EnQuireBio | 25mg | EUR 675.6 |
Recombinant other Histrelin Protein, Untagged, E.coli-25mg |
|||
| QP12236-25mg | EnQuireBio | 25mg | EUR 708 |
Recombinant Human Leuprorelin Protein, Untagged, E.coli-25mg |
|||
| QP12555-25mg | EnQuireBio | 25mg | EUR 349.2 |
Recombinant Human LHRH Protein, Untagged, E.coli-25mg |
|||
| QP12569-25mg | EnQuireBio | 25mg | EUR 218.4 |
Recombinant other Lypressin Protein, Untagged, E.coli-25mg |
|||
| QP12608-25mg | EnQuireBio | 25mg | EUR 241.2 |
Recombinant other MOG Protein, Untagged, E.coli-25mg |
|||
| QP12717-25mg | EnQuireBio | 25mg | EUR 708 |
Recombinant other DDAVP Protein, Untagged, E.coli-25mg |
|||
| QP11607-25mg | EnQuireBio | 25mg | EUR 708 |
However, the strain-dependent differences are found. The most remarkable effect was found for Lactobacillus acidophilus CRL2074, which reduces the expression of IL-1α , IL-1β , MCP- 1 , IL-8 and CXCL 3 , and Lactobacillus rhamnosus CRL2084 reduced IL-1β , MCP-1 and IL-8 expression.