Monocyte chemotactic protein-1 and nitrotyrosine in irritable bowel syndrome
Irritable bowel syndrome (IBS) is one of the most frequent and common functional gastrointestinal disorder that has aetiopathogenesis multifactorial. Several biomarkers have been tested in the search for a reliable and specific biomarkers, but there is no specific biomarkers for IBS. The purpose of this study was to evaluate two different biomarkers putative pathways of pathogenesis of IBS: monocyte chemotactic protein-1 (MCP-1) and nitrotyrosine, in order to establish their role as potential biomarkers.
We enrolled 42 consecutive patients diagnosed with IBS by Rome III criteria and 35 healthy controls, respectively. serum concentration of two biomarkers (MCP-1 and nitrotyrosine) is determined by using a commercial ELISA kit. serum levels of MCP-1 were not statistically significantly higher in IBS patients than the control group (204 ± 130 vs 174 ± 73 pg / ml; P = 0.311). nitrotyrosine levels were statistically significantly lowered in IBS patients than the control group (30 ± 12 vs 353 ± 14 nM; P = 0.050).
MCP-1 levels were higher in patients with the metabolic syndrome compared IBS IBS patients without metabolic syndrome (239 ± 153 vs 168 ± 120 pg / ml; P = 0.948) and in control with the metabolic syndrome (174 ± 56 pg / ml). MCP-1 serum levels were statistically significantly higher in IBS patients with the metabolic syndrome compared with controls (239 ± 153 vs 157 ± 89 pg / ml; P = 0.037), showing several factors involved, especially diet and its association with metabolic syndrome, and it shows that MCP-1 coul
Evaluation of Immunomodulatory Ability of Lactic Acid Bacteria Isolated from Cattle Feedlot Against Mastitis Using Bovine Mammary Epithelial Cells In Vitro Assay
bovine mastitis, an inflammation of the mammary gland, affecting the quality and quantity of milk production. mastitis control relies on a combination of one or more antibiotic therapy. Because of the increasing antibiotic resistance in pathogens, intramammary infusion of lactic acid bacteria (LAB) has been considered as a potential alternative to antibiotics to treat and prevent bovine mastitis through the host immune enhancement. the effect of probiotic strain-dependent characteristics;
Therefore, strains of LAB candidate must be evaluated efficiently identify those with the best potential. Here, we examine the LAB strains were originally isolated from the environment fattening cattle on their ability to induce the Toll-like receptor (TLR) -triggered inflammatory response in bovine mammary epithelial (BME) cells in vitro.
BME cells were pre-stimulated with LAB strains individually for 12, 24, and 48 hours and then challenged with Escherichia coli -derived lipopolysaccharide (LPS) for 12 hours. MRNA expression of immune selected gene-interleukin 1 alpha ( IL-1α ), IL-1β , monocytes chemotactic protein 1 ( MCP-1 ), IL-8 , chemokine (CXC motif) ligand 2 ( CXCL2 ), and CXCL 3 as measured by real-time quantitative PCR (RT-qPCR). The results showed that pretreatment with few Lactobacillus strains capable of differentially regulate inflammatory responses in cell LPS BME;
(RS)-MCPG |
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| B6265-5.1 | ApexBio | 10 mM (in 1mL DMSO) | EUR 250.8 |
(RS)-MCPG |
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| B6265-50 | ApexBio | 50 mg | EUR 490 |
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Description: mGluR antagonist |
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(S)-MCPG |
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| B6266-10 | ApexBio | 10 mg | EUR 146 |
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Description: mGluR antagonist |
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(S)-MCPG |
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| B6266-25 | ApexBio | 25 mg | EUR 304 |
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Description: mGluR antagonist |
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(S)-MCPG |
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| B6266-5 | ApexBio | 5 mg | EUR 106 |
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Description: mGluR antagonist |
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(S)-MCPG |
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| B6266-50 | ApexBio | 50mg | EUR 523 |
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Description: mGluR antagonist |
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(RS)-MCPG |
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| 555671 | MedKoo Biosciences | 100.0mg | EUR 950 |
(RS)-MCPG |
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| HY-100371 | MedChemExpress | 100mg | EUR 1135.2 |
(S)-MCPG |
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| HY-100406 | MedChemExpress | 5mg | EUR 159.6 |
(S)-MCPG |
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| M199718 | Toronto Research Chemicals | 1g | EUR 7600 |
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Description: 150145-89-4 |
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(RS)-MCPG |
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| M264743 | Toronto Research Chemicals | 100mg | EUR 3000 |
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Description: 146669-29-6 |
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(RS)-MCPG |
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| T3479-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: (RS)-MCPG |
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(RS)-MCPG |
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| T3479-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: (RS)-MCPG |
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(S)-MCPG |
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| T13452-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: (S)-MCPG |
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(S)-MCPG |
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| T13452-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: (S)-MCPG |
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(RS)-MCPG |
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| MBS579609-10mg | MyBiosource | 10mg | EUR 180 |
(RS)-MCPG |
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| MBS579609-25mg | MyBiosource | 25mg | EUR 275 |
(RS)-MCPG |
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| MBS579609-2mg | MyBiosource | 2mg | EUR 145 |
(RS)-MCPG |
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| MBS579609-50mg | MyBiosource | 50mg | EUR 410 |
(RS)-MCPG |
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| MBS579609-5mg | MyBiosource | 5mg | EUR 160 |
(S)-MCPG |
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| MBS3844992-100mg | MyBiosource | 100mg | EUR 825 |
(S)-MCPG |
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| MBS3844992-10mg | MyBiosource | 10mg | EUR 200 |
(S)-MCPG |
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| MBS3844992-50mg | MyBiosource | 50mg | EUR 440 |
(S)-MCPG |
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| MBS3844992-5mg | MyBiosource | 5mg | EUR 155 |
(S)-MCPG |
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| MBS3844992-5x100mg | MyBiosource | 5x100mg | EUR 3695 |
(RS)-MCPG |
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| MBS3845259-100mg | MyBiosource | 100mg | EUR 910 |
(RS)-MCPG |
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| MBS3845259-10mg | MyBiosource | 10mg | EUR 210 |
(RS)-MCPG |
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| MBS3845259-50mg | MyBiosource | 50mg | EUR 485 |
(RS)-MCPG |
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| MBS3845259-5mg | MyBiosource | 5mg | EUR 165 |
(RS)-MCPG |
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| MBS3845259-5x100mg | MyBiosource | 5x100mg | EUR 4085 |
(RS)-MCPG |
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| MBS3607307-10mg | MyBiosource | 10mg | EUR 245 |
(RS)-MCPG |
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| MBS3607307-25mg | MyBiosource | 25mg | EUR 340 |
(RS)-MCPG |
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| MBS3607307-2mg | MyBiosource | 2mg | EUR 200 |
(RS)-MCPG |
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| MBS3607307-50mg | MyBiosource | 50mg | EUR 475 |
(RS)-MCPG |
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| MBS3607307-5mg | MyBiosource | 5mg | EUR 220 |
(S)-MCPG |
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| MBS5754201-200mg | MyBiosource | 200mg | EUR 1055 |
(S)-MCPG |
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| MBS5754201-5x200mg | MyBiosource | 5x200mg | EUR 4610 |
MCPG (sodium) |
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| HY-103570 | MedChemExpress | Get quote | Ask for price |
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Description: MCPG is a carboxylic phenyl glycine. MCPG can block metabotropic glutamate receptor (mGluR)(HY-15129) and has antagonistic activity of mGluR subtype. MCPG can be used to study the induction and maintenance of long-term potentiation (LTP) [1]. |
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(RS)-MCPG disodium salt |
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| B7476-10 | ApexBio | 10 mg | EUR 126 |
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Description: group I/group II metabotropic glutamate receptor antagonist |
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(RS)-MCPG disodium salt |
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| B7476-100 | ApexBio | 100mg | EUR 900 |
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Description: group I/group II metabotropic glutamate receptor antagonist |
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(RS)-MCPG disodium salt |
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| B7476-25 | ApexBio | 25mg | EUR 278 |
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Description: group I/group II metabotropic glutamate receptor antagonist |
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(RS)-MCPG disodium salt |
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| B7476-5 | ApexBio | 5mg | EUR 91 |
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Description: group I/group II metabotropic glutamate receptor antagonist |
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(RS)-MCPG disodium salt |
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| B7476-50 | ApexBio | 50 mg | EUR 490 |
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Description: group I/group II metabotropic glutamate receptor antagonist |
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(RS)-MCPG disodium salt |
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| T23270-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| T23270-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: (RS)-MCPG disodium salt |
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(RS)-MCPG disodium salt |
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| MBS5757736-50mg | MyBiosource | 50mg | EUR 1140 |
(RS)-MCPG disodium salt |
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| MBS5757736-5x50mg | MyBiosource | 5x50mg | EUR 4970 |
Z-FR-AMC 25mg |
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| 10201 | Biotium | 25MG | EUR 167 |
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Description: N/A |
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Z-FR-AMC 25mg |
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| 10201-1 | Biotium | EA | EUR 167 |
Cy 5 Maleimide 25Mg - EACH |
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| PA15136 | Scientific Laboratory Supplies | EACH | EUR 5432.4 |
Amersham Cy5.5 Maleimide 25mg - EACH |
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| PA15636 | Scientific Laboratory Supplies | EACH | EUR 4468.5 |
Deoxyribonuclease I (DNase I), 25mg |
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| PC0704-25mg | Vivantis | each | Ask for price |
Klebsiella Selective Supplement (25mg/vl) |
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| 29760 | Sisco Laboratories | 5 vl | EUR 10.26 |
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Description: Part D |
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Goat Anti-Mouse IgG Fc, 25MG |
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| A008-25MG | Arbor Assays | 25MG | EUR 552.63 |
Goat Anti-Rabbit IgG Fc, 25MG |
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| A009-25MG | Arbor Assays | 25MG | EUR 552.63 |
Amersham CY3B NHS Ester 25MG - EACH |
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| PA63106 | Scientific Laboratory Supplies | EACH | EUR 6322.05 |
Chloramphenicol Solution, 25mg/mL in Methanol |
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| 40120754-1 | Glycomatrix | 25 tube(s) | EUR 79.62 |
Chloramphenicol Solution, 25mg/mL in Methanol |
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| 40120754-2 | Glycomatrix | 50 tube(s) | EUR 145.5 |
Streptomycin Sulfate Solution, 25mg/mL, Sterile |
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| 41910008-1 | Glycomatrix | 50 mL | EUR 43.56 |
Donkey Anti-Sheep IgG (H&L), 25MG |
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| A010-25MG | Arbor Assays | 25MG | EUR 552.63 |
Amersham Cy3 Mono NHS ester 25mg - EACH |
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| PA13106 | Scientific Laboratory Supplies | EACH | EUR 4062.15 |
Amersham Cy5 mono NHS ester 25mg - EACH |
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| PA15106 | Scientific Laboratory Supplies | EACH | EUR 5108.4 |
Amersham Cy5.5 mono NHS ester 25mg - EACH |
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| PA15606 | Scientific Laboratory Supplies | EACH | EUR 4468.5 |
Caffeine Standard 25mg/L in Water - 5ML |
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| CAFSTD25005 | Scientific Laboratory Supplies | 5ML | EUR 275.4 |
OOMC00021-25MG - Carfilzomib |
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| OOMC00021-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOMC00024-25MG - JQ1 (+) |
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| OOMC00024-25MG | Aviva Systems Biology | 25mg | EUR 339 |
OOMC00027-25MG - Ascomycin |
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| OOMC00027-25MG | Aviva Systems Biology | 25mg | EUR 169 |
OOMC00031-25MG - Dasatinib |
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| OOMC00031-25MG | Aviva Systems Biology | 25mg | EUR 139 |
OOMC00032-25MG - Everolimus |
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| OOMC00032-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00059-25MG - Baricitinib |
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| OOMC00059-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00062-25MG - Pridopidine |
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| OOMC00062-25MG | Aviva Systems Biology | 25mg | EUR 429 |
OOMC00063-25MG - Selinexor |
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| OOMC00063-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOMC00064-25MG - Bromosporine |
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| OOMC00064-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00068-25MG - S1RA |
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| OOMC00068-25MG | Aviva Systems Biology | 25mg | EUR 399 |
OOMC00069-25MG - Siramesine |
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| OOMC00069-25MG | Aviva Systems Biology | 25mg | EUR 329 |
OOMC00070-25MG - PRE084 |
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| OOMC00070-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OOMC00073-25MG - SA4503 |
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| OOMC00073-25MG | Aviva Systems Biology | 25mg | EUR 299 |
OOMC00077-25MG - Ruxolitinib |
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| OOMC00077-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00084-25MG - Acalabrutinib |
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| OOMC00084-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00085-25MG - Volasertib |
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| OOMC00085-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00086-25MG - Favipiravir |
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| OOMC00086-25MG | Aviva Systems Biology | 25mg | EUR 219 |
OOMC00087-25MG - Ponatinib |
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| OOMC00087-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OOMC00089-25MG - Boceprvir |
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| OOMC00089-25MG | Aviva Systems Biology | 25mg | EUR 329 |
OOAU00079-25MG - Piceatannol |
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| OOAU00079-25MG | Aviva Systems Biology | 25mg | EUR 289 |
OOAU00086-25MG - Sirtinol |
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| OOAU00086-25MG | Aviva Systems Biology | 25mg | EUR 479 |
OOAU00087-25MG - Garcinol |
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| OOAU00087-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOAU00092-25MG - IOX1 |
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| OOAU00092-25MG | Aviva Systems Biology | 25mg | EUR 579 |
OOAU00094-25MG - DMXAA |
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| OOAU00094-25MG | Aviva Systems Biology | 25mg | EUR 669 |
IC Multi Elem (7) Anion Std 25mg/L in H2O - 250ML |
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| IC-MIX1 | Scientific Laboratory Supplies | 250ML | EUR 279.07 |
ATPγS, 25mg * Shipped on DRY ICE must be shipped Overnight * |
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| M-NU-406-25 | MiTeGen | - | EUR 400 |
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Description: ATPγS, 25mg * Shipped on DRY ICE must be shipped Overnight * |
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OOMC00019-25MG - A77 1726 |
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| OOMC00019-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00022-25MG - RVX-208 |
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| OOMC00022-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00023-25MG - Dabrafenib (GSK2118436) |
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| OOMC00023-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00035-25MG - H89 - 2HCl |
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| OOMC00035-25MG | Aviva Systems Biology | 25mg | EUR 429 |
OOMC00036-25MG - PD-325901 |
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| OOMC00036-25MG | Aviva Systems Biology | 25mg | EUR 259 |
OOMC00057-25MG - INK-128 |
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| OOMC00057-25MG | Aviva Systems Biology | 25mg | EUR 139 |
OOMC00058-25MG - Santacruzamate A |
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| OOMC00058-25MG | Aviva Systems Biology | 25mg | EUR 219 |
OOMC00061-25MG - N4-Hydroxycytidine |
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| OOMC00061-25MG | Aviva Systems Biology | 25mg | EUR 329 |
OOMC00065-25MG - BI-2536 |
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| OOMC00065-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00066-25MG - I-BET762 |
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| OOMC00066-25MG | Aviva Systems Biology | 25mg | EUR 399 |
OOMC00067-25MG - NE-100 |
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| OOMC00067-25MG | Aviva Systems Biology | 25mg | EUR 299 |
OOMC00072-25MG - BD1047 dihydrobromide |
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| OOMC00072-25MG | Aviva Systems Biology | 25mg | EUR 269 |
OOMC00082-25MG - Palbociclib (PD0332991) |
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| OOMC00082-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00083-25MG - MK-2206 |
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| OOMC00083-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OOAU00073-25MG - BML-278 |
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| OOAU00073-25MG | Aviva Systems Biology | 25mg | EUR 389 |
OOAU00075-25MG - EX-527 |
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| OOAU00075-25MG | Aviva Systems Biology | 25mg | EUR 389 |
OOAU00083-25MG - BML-210 |
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| OOAU00083-25MG | Aviva Systems Biology | 25mg | EUR 479 |
OOAU00084-25MG - C-646 |
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| OOAU00084-25MG | Aviva Systems Biology | 25mg | EUR 579 |
OOAU00088-25MG - BIX-01294 |
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| OOAU00088-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OPPA00535-25MG - Insulin Protein |
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| OPPA00535-25MG | Aviva Systems Biology | 25mg | EUR 154 |
OORA00210-25MG - DNA (Calf Thymus) |
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| OORA00210-25MG | Aviva Systems Biology | 25mg | EUR 179 |
OOAU00076-25MG - FK-866 HCl |
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| OOAU00076-25MG | Aviva Systems Biology | 25mg | EUR 539 |
OPSA10621-25MG - NATIVE UBIQUITIN Protein |
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| OPSA10621-25MG | Aviva Systems Biology | 25mg | EUR 449 |
Kinesis TELOS QuEChERS Clean-up Kit Dispersive Fruit and Veg; EN 15662; 150mg MgSO4 and 25mg PSA; 2ml - PK100 |
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| CHR6480 | Scientific Laboratory Supplies | PK100 | EUR 189 |
OOSA09676-25MG - HORSERADISH PEROXIDASE Accessory Reagent |
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| OOSA09676-25MG | Aviva Systems Biology | 25mg | EUR 369 |
OOMC00044-25MG - Miglustat HCl (N-Butyldeoxynojirimycin) |
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| OOMC00044-25MG | Aviva Systems Biology | 25mg | EUR 479 |
OOMC00078-25MG - 7-Cl-O-Nec1 |
|||
| OOMC00078-25MG | Aviva Systems Biology | 25mg | EUR 259 |
OASB02218-25MG - Human ZAP-70 Antibody |
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| OASB02218-25MG | Aviva Systems Biology | 25mg | EUR 99 |
OPPA01009-25MG - TP 5 - Thymopentin Protein |
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| OPPA01009-25MG | Aviva Systems Biology | 25mg | EUR 70 |
OPSA10512-25MG - NATIVE Human FIBRINOGEN Protein |
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| OPSA10512-25MG | Aviva Systems Biology | 25mg | EUR 199 |
OOMC00017-25MG - Ac-Leu-Leu-Methional (ALLM) |
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| OOMC00017-25MG | Aviva Systems Biology | 25mg | EUR 229 |
OASB02220-25MG - Human ZAP-70 Antibody : FITC |
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| OASB02220-25MG | Aviva Systems Biology | 25mg | EUR 129 |
OASB02224-25MG - Human ZAP-70 Antibody : Biotin |
|||
| OASB02224-25MG | Aviva Systems Biology | 25mg | EUR 129 |
OASB02226-25MG - Human ZAP-70 Antibody : PE |
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| OASB02226-25MG | Aviva Systems Biology | 25mg | EUR 139 |
OPSA10585-25MG - NATIVE Rabbit PHOSPHORYLASE B Protein |
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| OPSA10585-25MG | Aviva Systems Biology | 25mg | EUR 219 |
Recombinant other Antide Protein, Untagged, E.coli-25mg |
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| QP11028-25mg | EnQuireBio | 25mg | EUR 663.6 |
Recombinant Salmon Calcitonin Protein, Untagged, E.coli-25mg |
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| QP11261-25mg | EnQuireBio | 25mg | EUR 1622.4 |
Recombinant Human Secretin Protein, Untagged, E.coli-25mg |
|||
| QP13449-25mg | EnQuireBio | 25mg | EUR 544.8 |
Recombinant other Sincalide Protein, Untagged, E.coli-25mg |
|||
| QP13506-25mg | EnQuireBio | 25mg | EUR 675.6 |
Recombinant other Goserelin Protein, Untagged, E.coli-25mg |
|||
| QP12027-25mg | EnQuireBio | 25mg | EUR 469.2 |
Recombinant other Histrelin Protein, Untagged, E.coli-25mg |
|||
| QP12236-25mg | EnQuireBio | 25mg | EUR 708 |
Recombinant other Lypressin Protein, Untagged, E.coli-25mg |
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| QP12608-25mg | EnQuireBio | 25mg | EUR 241.2 |
However, the strain-dependent differences are found. The most remarkable effect was found for Lactobacillus acidophilus CRL2074, which reduces the expression of IL-1α , IL-1β , MCP- 1 , IL-8 and CXCL 3 , and Lactobacillus rhamnosus CRL2084 reduced IL-1β , MCP-1 and IL-8 expression.