Neuroinflammation has been involved in neurodegenerative diseases and acute brain injury such as stroke. monocytes chemotactic protein -1-induced protein -1 (Mcpip1) is a multifunctional protein action is known to have pro-apoptotic or anti-apoptotic depending on the nature of the experimental arrangement. However, its role in brain damage after asphyxia in the developing brain has not been studied. Therefore, we explored the role Mcpip1 on brain injury after hypoxia-ischemia in neonatal rats.

At postnatal day 7, Mcpip1-deficient and wild-type mice carotid artery ligation and exposure to hypoxia (8% oxygen). After a hypoxic-ischemic insult, we determine the time-course of cell death of apoptosis and expression levels of genes that encode proinflammatory factors. Mcpip1 impact on long-term brain damage rated one week after hypoxia-ischemia by cresyl violet staining.

We found caspase- 3 significantly increased activity in the ipsilateral brain tissue within 12-24 hours after hypoxia-ischemia. There is a marked increase in levels of mRNA transcripts that encode Mcpip1, TNF, and CCL2 in the ipsilateral brain tissue 6-48 hours after hypoxia-ischemia. We found caspase- hypoxia-ischemia-induced 3 and the activity levels of proinflammatory genes are inactivated in Mcpip1-KO mice compared to wild-type mice.

Histological assessment revealed that hypoxia-ischemia-induced brain tissue loss was significantly attenuated in the hippocampus of Mcpip1-KO mice compared to wild-type mice (9.0 ± 5.6% vs 3 3 0.9 ± 11.0%, P <0.05). Our data show that Mcpip1 contributes to acute and delayed brain damage, in part, through the regulation of neuroinflammation after hypoxic-ischemic insult in the developing rat brain.

Monocyte chemotactic protein-1-induced protein 1 contributes to neuronal injury following hypoxic-ischemia in the neonatal mouse brain
Monocyte chemotactic protein-1-induced protein 1 contributes to neuronal injury following hypoxic-ischemia in the neonatal mouse brain

MCP-1 priming Enhanced Mesenchymal stromal cells Therapeutic Effect on Contact Hypersensitivity by Enabling COX2-PGE2 / STAT3 Pathway mesenchymal stromal

cells (MSC) has become a promising treatment for inflammation-related diseases, and the efficacy of their therapy mainly depends on the crosstalk between the MSC and inflammation. However, methods to improve the efficiency of immunosuppressive of MSC in different diseases still need to be developed. In this study, we investigated whether preconditioning MSC inflammatory cytokines associated with the disease can improve their immunosuppressive properties and increasing the success of therapy.

In a mouse model of contact hypersensitivity (CHS), an inflammatory profile screening revealed that among all the cytokines tested, monocytes chemotactic protein -1 (MCP- 1) exhibited the lowest level increased significantly in the local microenvironment. As expected, MSC asphalt with MCP-1 (P-MSCs) exhibited an enhanced ability to downregulate the secretion of proinflammatory cytokines, induce regulatory T cells, inhibiting T cell proliferation, and the polarization of M2-type macrophages.

In vivo experiments showed that P-MSCs alleviated ear swelling and local production of proinflammatory cytokines is more effective than MSC controls. Mechanically, MCP-1 can significantly activate signal transducer and activator of transcription 3 (STAT 3 ) signaling pathway and induces the expression of cyclooxygenase-2 (COX2) and prostaglandin E2 (PGE2) in the MSC. STAT 3 inhibitor reversed MCP-1-mediated increase their immunosuppressive capabilities.

ATP (disodium salt)

HY-B0345A 10mM/1mL
EUR 113

Methoxatin (disodium salt)

HY-100196A 10mM/1mL
EUR 186

Fluorescein, disodium salt

FB0203 100g
EUR 63.92

POPSO, disodium salt

PB4959 25g
EUR 76.97

NADH (disodium salt)

HY-F0001 10mM/1mL
EUR 113

NADP (disodium salt)

HY-F0002A 500mg
EUR 271

Dimethylglyoxime disodium salt

DD1221 100g
EUR 63.92

ADA disodium salt

GB0256-100G 100 g
EUR 110

PIPES disodium salt

GB1799-100G 100 g
EUR 110

ADA disodium salt

GB0256-500G 500 g
EUR 341

PIPES disodium salt

GB1799-250G 250 g
EUR 181

PIPES disodium salt

GB1799-25G 25 g
EUR 70

PIPES disodium salt

GB1799-500G 500 g
EUR 309

POPSO disodium salt

GB6170-100G 100 g
EUR 269

POPSO disodium salt

GB6170-25G 25 g
EUR 126

Carbenicillin disodium salt

GA1299-10G 10 g
EUR 229

Carbenicillin disodium salt

GA1299-1G 1 g
EUR 86

Carbenicillin disodium salt

GA1299-250MG 250 mg
EUR 59

Carbenicillin disodium salt

GA1299-25G 25 g
EUR 341

Carbenicillin disodium salt

GA1299-5G 5 g
EUR 158

Ticarcillin disodium salt

GA1874-100MG 100 mg
EUR 50

Ticarcillin disodium salt

GA1874-1G 1 g
EUR 110

Ticarcillin disodium salt

GA1874-500MG 500 mg
EUR 78

Cefotetan disodium salt

GA5476-100MG 100 mg
EUR 86

Cefotetan disodium salt

GA5476-1G 1 g
EUR 181

Phosphomycin disodium salt

GA7173-1G 1 g
EUR 70

Phosphomycin disodium salt

GA7173-25G 25 g
EUR 289

Phosphomycin disodium salt

GA7173-5G 5 g
EUR 134

cGAMP disodium salt

GL2101-100UG 100 ug
EUR 160

cGAMP disodium salt

GL2101-500UG 500 ug
EUR 332

Balsalazide disodium salt

GP7647-1G 1 g
EUR 110

Etidronate disodium salt

GP3560-1G 1 g
EUR 174

Lobenzarit disodium salt

GP3753-100MG 100 mg
EUR 229

BCIP disodium salt

BB1171 500mg
EUR 232.7

NBQX disodium salt

B6566-10 10 mg
EUR 222

NBQX disodium salt

B6566-25 25 mg
EUR 389

NBQX disodium salt

B6566-5 5 mg
EUR 139

NBQX disodium salt

B6566-50 50 mg
EUR 683

CNQX disodium salt

B6567-1 1 mg
EUR 134

CNQX disodium salt

B6567-10 10 mg
EUR 215

CNQX disodium salt

B6567-50 50 mg
EUR 746

ATP disodium salt

B3304-5.1 10 mM (in 1mL H2O)
EUR 108
Description: ATP Disodium salt is a P2 purinoceptor agonist.

ATP disodium salt

B3304-50 50 mg
EUR 128
Description: ATP Disodium salt is a P2 purinoceptor agonist.

ATP disodium salt

B3304-S Evaluation Sample
EUR 81
Description: ATP Disodium salt is a P2 purinoceptor agonist.

Phosphoramidon Disodium Salt

B4790-25 25 mg
EUR 490
Description: Phosphoramidon Disodium Salt is a potent inhibitor of metalloproteinase [1]. Metalloproteinase is an enzyme whose catalytic mechanism involves a metal. Most metalloproteases require zinc and some require cobalt.

Phosphoramidon Disodium Salt

B4790-5 5 mg
EUR 189
Description: Phosphoramidon Disodium Salt is a potent inhibitor of metalloproteinase [1]. Metalloproteinase is an enzyme whose catalytic mechanism involves a metal. Most metalloproteases require zinc and some require cobalt.

DNQX disodium salt

B5288-100 100 mg
EUR 279

DNQX disodium salt

B5288-25 25 mg
EUR 128

DNQX disodium salt

B5288-50 50 mg
EUR 186

Carbenicillin, Disodium Salt

A2511-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Carbenicillin inhibits the cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidase on the inner surface of the bacterial cell membrane.Carbenicillin is a white to slightly yellow, hygroscopic powder soluble in water and in alcohol.

Carbenicillin, Disodium Salt

A2511-50 50 mg
EUR 131
Description: Carbenicillin inhibits the cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidase on the inner surface of the bacterial cell membrane.Carbenicillin is a white to slightly yellow, hygroscopic powder soluble in water and in alcohol.

UDP disodium salt

B7278-5.1 10 mM (in 1mL DMSO)
EUR 108

UDP disodium salt

B7278-50 50 mg
EUR 125

Phosphocreatine disodium salt

B7648-25 25 mg
EUR 196

Hypoxanthine Disodium Salt

B1185-1G
EUR 109

Hypoxanthine Disodium Salt

B1185-5G
EUR 240

cGAMP disodium salt

2435-100
EUR 196

NADH, disodium salt

2735-1000
EUR 169

NADH, disodium salt

2735-500
EUR 142

NADH, disodium salt

2735-5000
EUR 544

NADP, disodium salt

2736-100
EUR 153

NADP, disodium salt

2736-1000
EUR 784

NADP, disodium salt

2736-500
EUR 457

NBQX disodium salt

2759-25
EUR 642

NBQX disodium salt

2759-5
EUR 207

BCA disodium salt

2810-100G
EUR 865

BCA disodium salt

2810-1G
EUR 120

BCA disodium salt

2810-500G
EUR 2605

BCA disodium salt

2810-5G
EUR 218

MUP, disodium salt, trihydrate

M0740 1g
EUR 93.5

UDP-GlcNAc Disodium Salt

HY-112174 5mg
EUR 165

EDTA, disodium salt, dihydrate

EB0185 500g
EUR 70.01

EDTA disodium salt dihydrate

GE3023-100G 100 g
EUR 40

EDTA disodium salt dihydrate

GE3023-1KG 1 kg
EUR 70

EDTA disodium salt dihydrate

GE3023-250G 250 g
EUR 46

EDTA disodium salt dihydrate

GE3023-500G 500 g
EUR 54

EDTA disodium salt dihydrate

GE3023-5KG 5 kg
EUR 150

Pamoic acid disodium salt

GK6564-100G 100 g
EUR 86

Pamoic acid disodium salt

GK6564-250G 250 g
EUR 142

Pamoic acid disodium salt

GK6564-25G 25 g
EUR 54

Sulfobromophthalein disodium salt hydrate

GK6995-25G 25 g
EUR 245

Sulfobromophthalein disodium salt hydrate

GK6995-5G 5 g
EUR 110

Clodronate disodium salt hydrate

GP6103-1G 1 g
EUR 86

Bathocuproinedisulfonic acid disodium salt

GT0734-100MG 100 mg
EUR 50

Bathocuproinedisulfonic acid disodium salt

GT0734-1G 1 g
EUR 110

Bathocuproinedisulfonic acid disodium salt

GT0734-250MG 250 mg
EUR 62

Bathocuproinedisulfonic acid disodium salt

GT0734-500MG 500 mg
EUR 80

ADA buffer, disodium salt

AB0005 25g
EUR 66.53

CL 316243 disodium salt

B6766-1 1 mg
EUR 109
Description: EC50: (3.0±0.3) X 10-8 M for ?3 adrenoceptor [1].Benzodioxole-containing phenethanolamine CL-316,243 is a murine-selective ?3 adrenoceptor agonist which can correct obesity and elevated blood glucose in diabetic rodents.

CL 316243 disodium salt

B6766-10 10 mg
EUR 293
Description: EC50: (3.0±0.3) X 10-8 M for ?3 adrenoceptor [1].Benzodioxole-containing phenethanolamine CL-316,243 is a murine-selective ?3 adrenoceptor agonist which can correct obesity and elevated blood glucose in diabetic rodents.

CL 316243 disodium salt

B6766-5 5 mg
EUR 206
Description: EC50: (3.0±0.3) X 10-8 M for ?3 adrenoceptor [1].Benzodioxole-containing phenethanolamine CL-316,243 is a murine-selective ?3 adrenoceptor agonist which can correct obesity and elevated blood glucose in diabetic rodents.

Pamoic acid disodium salt

B7638-10 10 mg
EUR 480

Pamoic acid disodium salt

B7638-50 50 mg
EUR 1861

EDTA, Disodium Salt, Dihydrate

CH032 500 g
EUR 163

EDTA, Disodium Salt, Dihydrate

CH033 1.0 kg
EUR 195

EDTA, Disodium Salt, Dihydrate

CH034 2.5 kg
EUR 334

Dexamethasone phosphate . disodium salt

21-804 5 g
EUR 398.9
Description: Dexamethasone phosphate is a water-soluble form of the synthetic glucocorticoid dexamethasone (AG-CR1-3742).Dexamethasone is a potent anti-inflammatory and immunosuppressive agent useful in a variety of inflammatory and autoimmune conditions.This synthetic glucocorticoid acts as an agonist of human glucocorticoid receptor (GR) and binds with a higher affinity than the natural ligand cortisol (Kd = 5nM versus 17nM, respectively). Through GR activation, dexamethasone has both transactivating and transrepressing effects on gene expression, resulting in anti-inflammatory properties. The anti-inflammatory effects are complex, but primarily via inhibition of inflammatory cells and suppression of expression of inflammatory mediators.Dexamethasone has been shown to regulate T cell survival, growth and differentiation. It induces the production of phospholipase A2 inhibitory protein (lipocortin) and inhibits the induction of nitric oxide synthase (IC50 = 5nM). Dexamethasone is used to study apoptosis, cell signaling pathways, cell differentiation and gene expression. It also has been shown to be an activator of IDO through the induction of the GITR-GITRL pathway.Reduces levels of activated NF-κB in immature dendritic cells (DCs) and inhibits differentiation into mature DCs. Induces differentiation of human mesenchymal stem cells (MSCs). Also induces autophagy in acute lymphoblastic leukemia (ALL) cell lines.Dexamethasome is used in combination with several anticancer agents to improve the activity and has been shown to be useful in reducing the inflammatory factors in viral infections (EBV, RSV).The RECOVERY Trial recommended dexamethasone for use in COVID-19 patients with severe respiratory symptoms. Dexamethasone improves survival rates of hospitalized patients with COVID-19 by inhibiting cytokine storm.

MUP, disodium salt [4-Methylumbelliferyl phosphate, disodium salt] *CAS 22919-26-2*

11610 25 mg
EUR 115

MUP, disodium salt [4-Methylumbelliferyl phosphate, disodium salt] *CAS 22919-26-2*

11612 10 g
EUR 898

NADH disodium salt, trihydrate, reduced

NB0642 1g
EUR 82.19

Guanosine 5'-diphosphate disodium salt

HY-113066A 10mg
EUR 119

Glycerophosphoric acid (disodium salt hydrate)

HY-126304 100mg
EUR 108

Oleanolic acid hemiphthalate disodium salt

HY-128695 10mM/1mL
EUR 625

Uridine 5′-diphosphoglucose (disodium salt)

HY-N7032 100mg
EUR 108

Uridine-5'-diphosphate disodium salt

HY-W010832 100mg
EUR 108

5'-Guanylic acid (disodium salt)

HY-W010970 10mM/1mL
EUR 113

Uridine 5'-monophosphate disodium salt

HY-W013175 100mg
EUR 108

EDTA disodium and monocalcium salt

EK014P2 500g
EUR 96.11

EDTA copper(II) disodium salt

EB0434 250g
EUR 83.93

EDTA disodium and monomagnesium salt

EB0435 500g
EUR 110.9

EDTA zinc (II), disodium salt

EB6666 100g
EUR 64.79

4-Methylumbelliferyl phosphate disodium salt

GC5745-1G 1 g
EUR 166

4-Methylumbelliferyl phosphate disodium salt

GC5745-250MG 250 mg
EUR 75

Uridine 5'-diphosphate disodium salt

GC9934-100MG 100 mg
EUR 74

Uridine 5'-diphosphate disodium salt

GC9934-1G 1 g
EUR 261

Uridine 5'-diphosphate disodium salt

GC9934-250MG 250 mg
EUR 110

Uridine 5'-diphosphate disodium salt

GC9934-25MG 25 mg
EUR 52

Uridine 5'-diphosphate disodium salt

GC9934-500MG 500 mg
EUR 162

Phenyl phosphate disodium salt dihydrate

GE1672-50G 50 g
EUR 99

Guanosine 5'-diphosphate disodium salt

GE3702-100MG 100 mg
EUR 118

Guanosine 5'-diphosphate disodium salt

GE3702-250MG 250 mg
EUR 174

EDTA magnesium disodium salt hydrate

GE3956-100G 100 g
EUR 66

EDTA magnesium disodium salt hydrate

GE3956-1KG 1 kg
EUR 245

EDTA magnesium disodium salt hydrate

GE3956-250G 250 g
EUR 102

EDTA magnesium disodium salt hydrate

GE3956-25G 25 g
EUR 45

EDTA magnesium disodium salt hydrate

GE3956-500G 500 g
EUR 154

Adenosine 5'-diphosphate disodium salt

GE3988-1G 1 g
EUR 78

Adenosine 5'-diphosphate disodium salt

GE3988-250MG 250 mg
EUR 50

L-Tyrosine disodium salt hydrate

GE4061-100G 100 g
EUR 84

L-Tyrosine disodium salt hydrate

GE4061-25G 25 g
EUR 48

L-Tyrosine disodium salt hydrate

GE4061-50G 50 g
EUR 61

Uridine 5'-monophosphate disodium salt

GE7138-100G 100 g
EUR 269

Uridine 5'-monophosphate disodium salt

GE7138-25G 25 g
EUR 110

Uridine 5'-monophosphate disodium salt

GE7138-5G 5 g
EUR 62

Creatine phosphate disodium salt hydrate

GE7721-100G 100 g
EUR 333

Creatine phosphate disodium salt hydrate

GE7721-25G 25 g
EUR 150

Creatine phosphate disodium salt hydrate

GE7721-5G 5 g
EUR 74

Phenyl phosphate disodium salt dihydrate

GE1672-100G 100 g
EUR 150

Phenyl phosphate disodium salt dihydrate

GE1672-10G 10 g
EUR 52

Phenyl phosphate disodium salt dihydrate

GE1672-25G 25 g
EUR 74

Collectively, our findings indicate that MCP-1 related CHS conditioning increases immunomodulatory effects of MSC and enhanced their therapeutic efficacy in CHS. Improving the effectiveness of immunosuppressive MSC by preconditioning inflammatory cytokines associated with a particular disease may provide new strategies for MSC-based therapy for inflammatory disease.